Administration of visfatin during superovulation improves developmental competency of oocytes and fertility potential in aged female mice

Choi, Ki Young; Joo, Bo Sun; Sun, Sheng-Ta; Park, Min-Jung; Son, Jung-Bin; Joo, Jong‐Kil; Lee, Kyusup

doi:10.1016/j.fertnstert.2012.02.032

Cited by 55 publications

(44 citation statements)

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“…In an animal model (mouse), administration of visfatin during superovulation improves developmental competency of oocytes and fertility potential, despite the age. These and other data support a role for visfatin in reproduction [18, 19]. In our experimental cohort, serum visfatin levels were not different in NOW-PCOS and control-NOW, but FF-visfatin levels were 1.6-fold higher, even though not significantly, in NOW-PCOS as compared with control-NOW.…”

Section: Discussionsupporting

confidence: 87%

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Association between Follicular Fluid Leptin and Serum Insulin Levels in Nonoverweight Women with Polycystic Ovary Syndrome

Garruti

Palo

Rotelli

et al. 2014

BioMed Research International

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Aims. We evaluated the links between leptin and visfatin levels and fertilization rates in nonoverweight (NOW) women with PCOS (NOW-PCOS) from Apulia undergoing in vitro fertilization/embryo transfer (IVF). Materials and Methodology. We recruited 16 NOW women with PCOS (NOW-PCOS) and 10 normally ovulating NOW women (control-NOW). All women underwent IVF. Androgens, 17-β-estradiol (17β-E2), and insulin levels were measured in plasma and/or serum and leptin and visfatin levels were assayed in both serum and follicular fluid (FF-leptin, FF-visfatin). Results. In NOW-PCOS, both serum and FF-leptin were significantly lower than in control-NOW. In NOW-PCOS, significant correlations were found between BMI and serum leptin and insulinemia and FF-leptin. By contrast, in control-NOW, FF-leptin levels were not correlated with insulinemia. Serum visfatin levels were not significantly different in NOW-PCOS and control-NOW, but FF-visfatin levels were 1.6-fold higher, although not significantly, in NOW-PCOS than in control-NOW. Conclusions. Both serum leptin levels and FF-leptin are BMI- and insulin-related in Southern Italian NOW-PCOS from Apulia. In line with other reports showing that FF-leptin levels are predictive of fertilization rates, lower than normal FF-leptin levels in NOW-PCOS may explain their lower fertilization rate and this may be related to the level of insulin and/or insulin resistance.

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Section: Discussionsupporting

confidence: 87%

“…Visfatin mRNA was recently detected in human follicles, and visfatin administration was shown to improve ovarian response in conditions of superovulation in animal models [18, 19]. …”

Section: Introductionmentioning

confidence: 99%

Association between Follicular Fluid Leptin and Serum Insulin Levels in Nonoverweight Women with Polycystic Ovary Syndrome

Garruti

Palo

Rotelli

et al. 2014

BioMed Research International

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“…Indeed, Seow et al showed that resistin was not a major determining factor in the growth and maturation of oocytes during ovarian stimulation [68], whereas Chen et al (2007) demonstrated a negative correlation between serum resistin levels and the number of oocytes retrieved during IVF [69]. In rodents, a recent study showed that administration of visfatin during superovulation improves the developmental competency of oocytes and fertility potential in old female mice suggesting a role of this adipokine in ovarian function and oocyte quality in older mammals [70]. …”

Section: Adipokines and Ovary (Figure 3)mentioning

confidence: 99%

Adipokines and the Female Reproductive Tract

Reverchon

Ramé

Bertoldo

et al. 2014

International Journal of Endocrinology

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It is well known that adipose tissue can influence puberty, sexual maturation, and fertility in different species. Adipose tissue secretes molecules called adipokines which most likely have an endocrine effect on reproductive function. It has been revealed over the last few years that adipokines are functionally implicated at all levels of the reproductive axis including the gonad and hypothalamic-pituitary axis. Many studies have shown the presence and the role of the adipokines and their receptors in the female reproductive tract of different species. These adipokines regulate ovarian steroidogenesis, oocyte maturation, and embryo development. They are also present in the uterus and placenta where they could create a favorable environment for embryonic implantation and play a key role in maternal-fetal metabolism communication and gestation. Reproductive functions are strongly dependent on energy balance, and thereby metabolic abnormalities can lead to the development of some pathophysiologies such as polycystic ovary syndrome (PCOS). Adipokines could be a link between reproduction and energy metabolism and could partly explain some infertility related to obesity or PCOS.

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“…Furthermore, in women who are undergoing controlled ovarian stimulation, there is a correlation between the concentration of NAMPT in the follicular fluids and the number of oocytes retrieved (Shen et al 2010). In rats, the administration of NAMPT during superovulation has been shown to play an important role in the regulation of oocyte quality, and it can improve oocyte quality and fertility in aged female mice (Choi et al 2012). NAMPT is expressed in the testes of male rats, more specifically in Leydig cells, spermatocytes and sperm (Gurusubramanian & Roy 2014).…”

Section: Introductionmentioning

confidence: 99%

Expression and effect of NAMPT (visfatin) on progesterone secretion in hen granulosa cells

Diot¹,

Reverchon²,

Ramé³

et al. 2015

Reproduction

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In mammals, nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine produced by adipose tissue that is found in intracellular and extracellular compartments. The intracellular form of NAMPT is a nicotinamide phosphoribosyltransferase, whereas the extracellular form is considered an adipokine. In humans, NAMPT regulates energy metabolism and reproductive functions, such as ovarian steroidogenesis. To date, no study has investigated the role of NAMPT in hen ovaries. We investigated whether NAMPT is present in hen ovarian follicles and its role in granulosa cells. Using RT-PCR, western blotting and immunocytochemistry, we detected mRNA transcripts and proteins related to NAMPT in theca and granulosa cells from pre-ovulatory follicles. Using RT-PCR, we demonstrated that mRNA NAMPT levels were higher in granulosa cells than they were in theca cells and that during follicle development, theca cell levels decreased, whereas levels remained unchanged in granulosa cells. NAMPT protein quantities were significantly higher in theca cells than they were in granulosa cells, but they were unchanged during follicular development. Plasma NAMPT levels, as determined by ELISA and immunoblotting, were significantly lower in adult hens than they were in juveniles. In vitro, treatment with human recombinant NAMPT (100 ng/ml, 48 h) halved basal and IGF1-induced progesterone secretion, and this was associated with a reduction in STAR and HSD3B protein levels and MAPK3/1 phosphorylation levels in granulosa cells. These effects were abolished by the addition of FK866, a specific inhibitor of NAMPT enzymatic activity. Moreover, NAMPT had no effect on granulosa cell proliferation. In conclusion, NAMPT is present in hen ovarian cells and inhibits progesterone production in granulosa cells.

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Administration of visfatin during superovulation improves developmental competency of oocytes and fertility potential in aged female mice

Cited by 55 publications

References 53 publications

Association between Follicular Fluid Leptin and Serum Insulin Levels in Nonoverweight Women with Polycystic Ovary Syndrome

Association between Follicular Fluid Leptin and Serum Insulin Levels in Nonoverweight Women with Polycystic Ovary Syndrome

Adipokines and the Female Reproductive Tract

Expression and effect of NAMPT (visfatin) on progesterone secretion in hen granulosa cells

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