Administration of vitamin D to ameliorate dyspnea of chronic obstructive pulmonary disease patients: a randomized controlled trial

Ghodrati, Samad; Ezzatpanah, Arian; Asadi-Khiavi, Masoud; Samakkah, Shohreh Alian; Esmaeilzadeh, Abdolreza; Pezeshgi, Aiyoub

doi:10.15171/ipp.2019.22

Cited by 4 publications

(2 citation statements)

References 23 publications

(27 reference statements)

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“…3.4.5. Compound Nutrients FEV1 and FEV1/FVC% Eight studies were found involving the effects of complex nutritional supplements on lung function in patients, but the number of meta-analysis results was inconsistent due to data issues [52][53][54][55][57][58][59][60], and only seven of these articles were analyzed. The results proved that FEV1 was significantly increased in COPD patients after receiving multinutrient supplementation (WMD de : 8.38, 95% CI: 1.89, 14.87, p < 0.05; WMD af : 7.07, 95% CI: −0.34, 14.48, p < 0.05, Figure 4A,B).…”

Section: Magnesiummentioning

confidence: 99%

Improvement of Lung Function by Micronutrient Supplementation in Patients with COPD: A Systematic Review and Meta-Analysis

Li,

Zhao,

et al. 2024

Nutrients

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Background: A healthy, well-balanced diet plays an essential role in respiratory diseases. Since micronutrient deficiency is relatively common in patients with chronic obstructive pulmonary disease (COPD), micronutrient supplementation might have the beneficial health effects in those patients. This systematic review and meta-analysis aimed to demonstrate the impact of micronutrient supplementation on the lung function of patients with COPD. Methods: The PubMed, Cochrane Library, and Web of Science databases were searched from their corresponding creation until February 2024. Search terms included ‘chronic obstructive pulmonary disease’, ‘COPD’, ‘micronutrients’, ‘dietary supplements’, ‘vitamins’, ‘minerals’, and ‘randomized controlled trials’. Meta-analysis was performed to evaluate the effects of micronutrient supplementation alone or complex on lung function in patients with COPD. Results: A total of 43 RCTs fulfilled the inclusion criteria of this study. Meta-analysis revealed that vitamin D supplementation could significantly improve FEV1% (WMDdifferences between baseline and post-intervention (de): 6.39, 95% CI: 4.59, 8.18, p < 0.01; WMDpost-intervention indicators (af): 7.55, 95% CI: 5.86, 9.24, p < 0.01) and FEV1/FVC% (WMDde: 6.88, 95%CI: 2.11, 11.65, WMDaf: 7.64, 95% CI: 3.18, 12.10, p < 0.001), decrease the odds of acute exacerbations, and improve the level of T-cell subsets, including CD3+%, CD4+%, CD8+%, and CD4+/CD8+% (all p < 0.01). The effects of compound nutrients intervention were effective in improving FEV1% (WMDde: 8.38, 95%CI: 1.89, 14.87, WMDaf: 7.07, 95%CI: −0.34, 14.48) and FEV1/FVC% (WMDde: 7.58, 95% CI: 4.86, 10.29, WMDaf: 6.00, 95% CI: 3.19, 8.81). However, vitamin C and vitamin E supplementation alone had no significant effects on lung function (p > 0.05). Conclusions: Micronutrient supplementation, such as vitamin D alone and compound nutrients, has improved effect on the lung function of patients with COPD. Therefore, proper supplementation with micronutrients would be beneficial to stabilize the condition and restore ventilation function for COPD patients.

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Section: Magnesiummentioning

confidence: 99%

Improvement of Lung Function by Micronutrient Supplementation in Patients with COPD: A Systematic Review and Meta-Analysis

Li,

Zhao,

et al. 2024

Nutrients

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“…Dastan et al documented the effect of vitamin D supplements on inflammation resolution by measuring serum levels of inflammatory markers [ 43 ]. Ghodrati et al performed a clinical trial and found out the curative role of this vitamin in treating dyspnea in COPD patients [ 44 ]. Supplementation can seemingly reduce the progression and morbidity of chronic diseases by decreasing the number of free radicals with antioxidant enzymes, as observed in the latest randomized control trial performed in Bangladesh by Anjum et al [ 45 ].…”

Section: Reviewmentioning

confidence: 99%

A Comprehensive Review on Vitamin D as a Novel Therapeutic Agent in Chronic Obstructive Pulmonary Disease

Saleem¹,

Sharif²,

Jarvis³

et al. 2021

Cureus

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Vitamin D has been playing an important role in the treatment of lung diseases. The non-calcemic effects of this vitamin and its role in chronic obstructive pulmonary disease (COPD) has drawn significant attention recently. Many studies have been conducted to explore the relationship between the two. We tested the hypothesis that vitamin D can act as an effective therapeutic agent for COPD by reviewing the correlation between the two and effectiveness along with the safety of supplemental vitamin D when used to treat chronic bronchitis and emphysema through clinical trials. An electronic search was conducted using combinations of keywords “vitamin D” and “COPD” from PubMed and Google scholar. Only relevant, human studies of all types were included from the last decade. A total of 36 articles were selected for review. Observational studies indicate a correlation between low serum 25(OH)D levels and obstructive lung disease pathology as well as clinical outcomes. Moreover, clinical trials were aimed to understand the impact of the use of vitamin D in improving disease indexes. These clinical trials used different drug regimes, mode of administration, and intervention duration with contrasting outcomes. Hypovitaminosis D is a common and harmful variant of this group of obstructive lung diseases, and correcting this deficiency can improve exacerbations, inflammation, lung functions, symptoms, and quality of life. These benefits are more prevalent in patients with low baseline serum 25 hydroxyvitamin D(25(OH)D) levels. Peroral is the most frequently used route of drug administration, however, further work is required to explore the pharmacological properties of vitamin D. There was not enough literature available about the safety of the drug of intervention.

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Long non coding RNAs reveal important pathways in childhood asthma: a future perspective

Goodarzi,

Nouri,

Nassaj

et al. 2023

J Mol Histol

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Administration of vitamin D to ameliorate dyspnea of chronic obstructive pulmonary disease patients: a randomized controlled trial

Cited by 4 publications

References 23 publications

Improvement of Lung Function by Micronutrient Supplementation in Patients with COPD: A Systematic Review and Meta-Analysis

Improvement of Lung Function by Micronutrient Supplementation in Patients with COPD: A Systematic Review and Meta-Analysis

A Comprehensive Review on Vitamin D as a Novel Therapeutic Agent in Chronic Obstructive Pulmonary Disease

Long non coding RNAs reveal important pathways in childhood asthma: a future perspective

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