Administration timing and duration-dependent effects of sesamin isomers on lipid metabolism in rats

Tateishi, Norifumi; Morita, Satoshi; Yamazaki, Izumi; Okumura, Hitoshi; Kominami, Masaru; Akazawa, Sota; Funaki, Ayuta; Tomimori, Namino; Rogi, Tomohiro; Shibata, Hiroshi; Shibata, Shigenobu

doi:10.1080/07420528.2019.1700998

Cited by 6 publications

(3 citation statements)

References 52 publications

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“…It is of note that not all types of oils benefit lymphatic transport of the payloads. For instance, sesame oil limits the absorption of cholesterol by inhibiting the micellar solubilization process 102 , 103 . Corn oil and poly-unsaturated fatty acid such as linoleic acid or linolenic acid disfavor absorption of some carotenoids probably due to the poor lipolysis capability and lower extent of micellarization 104 , 105 .…”

Section: The Chylomicron Pathwaymentioning

confidence: 99%

An update on oral drug delivery via intestinal lymphatic transport

Zi-chen

Lü

et al. 2021

Acta Pharmaceutica Sinica B

119

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Orally administered drug entities have to survive the harsh gastrointestinal environment, penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the systemic circulation. Whereas the gastrointestinal stability can be well maintained by taking proper measures, hepatic metabolism presents as a formidable barrier to drugs suffering from first-pass metabolism. The pharmaceutical academia and industries are seeking alternative pathways for drug transport to circumvent problems associated with the portal pathway. Intestinal lymphatic transport is emerging as a promising pathway to this end. In this review, we intend to provide an updated overview on the rationale, strategies, factors and applications involved in intestinal lymphatic transport. There are mainly two pathways for peroral lymphatic transport—the chylomicron and the microfold cell pathways. The underlying mechanisms are being unraveled gradually and nowadays witness increasing research input and applications.

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Section: The Chylomicron Pathwaymentioning

confidence: 99%

An update on oral drug delivery via intestinal lymphatic transport

Zi-chen

Lü

et al. 2021

Acta Pharmaceutica Sinica B

119

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“…[107] Other chronobiologically active compounds such as sesamin isomers (sesamin and episesamin) have also been investigated, whereby the administration of sesamin isomers with olive oil at the beginning of the active phase was able to improve lipid metabolism in mice where dyslipidemia was induced after a prolonged (28 days) high fat diet, by regulating the expression of genes involved in cholesterol metabolism as well as liver clock genes. [108] More recently, the venture into novel nutraceuticals/bioactives as chronobiotics in the treatment of circadian desynchrony has shown promising results. Compounds such as Resveratrol, nobiletin, piceatannol, and ursolic acid have been shown to be capable of ameliorating high fat diet-induced circadian desynchrony in hepatocyte cultures and animal studies, by reverting disruptions and phase-shifting clock genes involved in lipid and glucose metabolism.…”

Section: Non-nutrient Bioactivesmentioning

confidence: 99%

Is There a Utility of Chrono‐Specific Diets in Improving Cardiometabolic Health?

Yong

Henry

Haldar

2022

Molecular Nutrition Food Res

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Modern lifestyle is generally associated with the consumption of three main meals per day, one of which is typically in the evening or at night. It is also well established that consumption of meals in the later part of the day, notably in the evenings, is associated with circadian desynchrony, which in turn increases the risk of non-communicable diseases, particularly cardiometabolic diseases. While it is not feasible to avoid food consumption during the evenings altogether, there is an opportunity to provide chrono-specific, diet-based solutions to mitigate some of these risks. To date, there has been substantial progress in the understanding of chrononutrition, with evidence derived mainly from in vitro and in vivo animal studies. Some of these approaches include the manipulation of the quality and quantity of certain nutrients to be consumed at specific times of the day, as well as incorporating certain dietary components (macronutrients, micronutrients, or non-nutrient bioactives, including polyphenols) with the ability to modulate circadian rhythmicity. However, robust human studies are generally lacking. In this review, the study has consolidated and critically appraised the current evidence base, with an aim to translate these findings to improve cardiometabolic health and provides recommendations to move this field forward.

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“…Catechin suppressed the elevation of postprandial glucose more effectively when taken in the evening than in the morning (21). Continuous beginning of the active phase administration of sesamin and episesamin improved lipid metabolism compared to administration at the end of the active phase (22). Morning intake of fish oil, which is abundant in docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), suppressed serum triglyceride levels and decreased serum total saturated fatty acids and serum n-6 polyunsaturated fatty acids (23).…”

Section: Introductionmentioning

confidence: 99%

Association Between Na, K, and Lipid Intake in Each Meal and Blood Pressure

et al. 2022

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Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide, and one of the most significant risk factors for CVDs is high blood pressure. Blood pressure is associated with various nutrients, such as sodium, potassium, and cholesterol. However, research focusing on the timing of intake of these nutrients and blood pressure has not been conducted. In this study, we used dietary data and a questionnaire asking about the sleep, physical activity, and blood pressure, collected from the food-log app “Asken” (total N = 2,402), to investigate the relationship between the dietary data of nutrient intake in the breakfast, lunch, and dinner and blood pressure. Daily total intake of various nutrients such as sodium, sodium-to-potassium ratio, total energy, lipid, carbohydrate, and saturated fat showed a significant association with blood pressure depending on the meal timing. From multiple regression analysis, eliminating the confounding factors, lunch sodium-to-potassium ratio, dinner energy, lipid, cholesterol, saturated fat, and alcohol intake were positively associated with blood pressure, whereas breakfast protein and lunch fiber intake showed a negative association with blood pressure. Our results suggest that nutrient intake timing is also an important factor in the prevention of high blood pressure. Our study provides possibilities to prevent hypertension by changing the timing of nutrient intake, especially sodium, together with potassium and lipids. However, because our research was limited to food-log app users, broader research regarding the general population needs to be conducted.

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Administration timing and duration-dependent effects of sesamin isomers on lipid metabolism in rats

Cited by 6 publications

References 52 publications

An update on oral drug delivery via intestinal lymphatic transport

An update on oral drug delivery via intestinal lymphatic transport

Is There a Utility of Chrono‐Specific Diets in Improving Cardiometabolic Health?

Association Between Na, K, and Lipid Intake in Each Meal and Blood Pressure

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