Admission Hyperglycemia Is an Independent Predictor of Acute Kidney Injury in Patients With Acute Myocardial Infarction

Moriyama, Noriaki; Ishihara, Masaharu; Noguchi, Teruo; Sakamoto, Hiroki; Nakanishi, Masayoshi; Kotani, Jun–ichi; Asaumi, Yasuhide; Kumasaka, Leon; Adachi, Taichi; Yamane, Takafumi; Miyagi, Tadayoshi; Nagai, Toshiyuki; Fujino, Masashi; Matsumoto, Manabu; Honda, Satoshi; Yagyu, Takeshi; Fujiwara, Reiko; Fujino, Akiko; Anzai, Toshihisa; Shimizu, Wataru; Yasuda, Satoshi; Ogawa, Hisao

doi:10.1016/s0735-1097(13)60171-0

Cited by 4 publications

(4 citation statements)

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“…The association between high glucose levels and acute kidney injury is supported by previous studies [13][14][15]. Marinzi et al [16] in 2010 showed that in STEMI patients treated with primary PCI, acute hyperglycemia was an independent predictor of CIN, where patients with acute hyperglycemia had a 2-fold higher incidence of CIN than those without acute hyperglycemia (p<0.001) (27% vs 12%, P < 0.001).…”

Section: Discussionmentioning

confidence: 66%

Acute Hyperglycemia an Independent Risk Factor for Contrast-Induced Nephropathy in Patients Undergoing Primary Percutaneous Coronary Intervention for STEMI

Khorshid

Gomaa

Tamara

et al. 2017

JCCR

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Section: Discussionmentioning

confidence: 66%

Acute Hyperglycemia an Independent Risk Factor for Contrast-Induced Nephropathy in Patients Undergoing Primary Percutaneous Coronary Intervention for STEMI

Khorshid

Gomaa

Tamara

et al. 2017

JCCR

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“…Albuminuria occurs commonly in new diagnosed diabetic patients especially those with diabetic ketosis, who are usually misdiagnosed as "diabetic kidney disease". For critically ill patients with or without pre-diagnosed diabetes, acute elevated blood glucose could increase the incidence of acute kidney injury, and strict control of blood glucose could improve this outcome (1,(16)(17)(18). Animal studies also proved that acute hyperglycemia induced by anesthetics or serious burns could lead to glomerular filtration function impairment and tubular dilatation (19,20).…”

Section: Discussionmentioning

confidence: 99%

Acute Hyperglycemia May Induce Renal Tubular Injury Through Mitophagy Inhibition

et al. 2020

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AimAcute hyperglycemia is closely related to kidney injury. Oxidative stress activation and notable mitochondria damages were found under acute hyperglycemia treatment in our previous work. In the present study, we explored the dose-effect relationship and the pivotal role of mitophagy in acute hyperglycemia induced tubular injuries.MethodsForty non-diabetic SD rats were randomly divided and treated with different concentrations of hyperglycemia respectively during the 6-h clamp experiment. Renal morphological and functional alterations were detected. Rat renal tubular epithelial cells were treated with different concentrations of glucose for 6 h. Markers and the regulation pathway of mitophagy were analyzed.ResultsSignificant tubular injuries but not glomeruli were observed under both light and electron microscope after acute hyperglycemia treatment, which manifested as enlargement of tubular epithelial cells, disarrangement of epithelial cell labyrinths and swelling of mitochondria. Urinary microalbumin, β2-MG, CysC, NAG, GAL, and NGAL were increased significantly with the increase of blood glucose (P < 0.05). ROS was activated, mitochondrial membrane potential and LC3-II/LC3-I ratio were decreased but P62 and BNIP3L/Nix were increased in hyperglycemia groups (P < 0.05), which were reversed by AMPK activation or mTOR inhibition.ConclusionAcute hyperglycemia causes obvious tubular morphological and functional injuries in a dose-dependent manner. Acute hyperglycemia could inhibit mitophagy through AMPK/mTOR pathway, which would aggravate mitochondria damage and renal tubular impairment.

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“…1 This report is important because they show that admission hyperglycemia was an independent risk factor for AKI in patients with AMI. And patients with admission hyperglycemia were at higher risk of death during hospitalization for AMI, regardless of the use of coronary angiography (CAG) or primary percutaneous coronary intervention (PCI).…”

mentioning

confidence: 82%

Acute Kidney Injury and Acute Myocardial Infarction

Ebina

Kosuge

Kimura

2014

Circ J

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Admission Hyperglycemia Is an Independent Predictor of Acute Kidney Injury in Patients With Acute Myocardial Infarction

Cited by 4 publications

References 0 publications

Acute Hyperglycemia an Independent Risk Factor for Contrast-Induced Nephropathy in Patients Undergoing Primary Percutaneous Coronary Intervention for STEMI

Acute Hyperglycemia an Independent Risk Factor for Contrast-Induced Nephropathy in Patients Undergoing Primary Percutaneous Coronary Intervention for STEMI

Acute Hyperglycemia May Induce Renal Tubular Injury Through Mitophagy Inhibition

Acute Kidney Injury and Acute Myocardial Infarction

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