Admission kidney function is a strong predictor for the response to nutritional support in patients at nutritional risk

Admission serum albumin concentrations and response to nutritional therapy in hospitalised patients at malnutrition risk: Secondary analysis of a randomised clinical trial

“…It was approved by the ethics committee of Northwestern Switzerland (EKNZ; 2014_001) and was registered at ClinicalTrials.gov in August 2015 ( https://clinicaltrials.gov/ct2/show/NCT02517476 ). The trial protocol, 14 the main results 10 as well as results regarding long-term outcomes, 15 cost outcomes 16 and results of secondary analyses 12 , 13 , 17 , 18 , 19 , 20 , 21 , 22 have been published previously. All patients provided written informed consent.…”

Nutritional support during the hospital stay reduces mortality in patients with different types of cancers: secondary analysis of a prospective randomized trial

“…The trial protocol and the results of the main trial, as well as secondary outcomes, have been published previously. [4,11,[16][17][18][19][20][21][22] The Ethics Committee of Northwest and Central Switzerland (EKNZ) approved the study protocol in January 2014 (EKNZ; 2014_001).…”

Association of metabolomic markers and response to nutritional support: A secondary analysis of the EFFORT trial using an untargeted metabolomics approach

“…Indeed, highly inflamed patients with C-reactive protein (CRP) levels >100 mg/dl did not show a response to nutritional intervention with significant results in the interaction analysis, potentially explaining why nutrition may only show little beneficial results in patients with high severity of illness [15,50]. On the other hand, impairment in admission kidney function was a strong predictor for the response to treatment in our analysis [49]. Other potential effect modifiers identified within the EFFORT population were muscle strength measured through handgrip strength [51] and low nutritional intake [11,14].…”

“…In turn, this is clinically reflected in cachexia and a frail patient state [47,48]. In a previous analysis of the EFFORT trial, we found that inflammation [15] as well as kidney function [49] were key drivers of the effect of nutritional support on outcomes. Indeed, highly inflamed patients with C-reactive protein (CRP) levels >100 mg/dl did not show a response to nutritional intervention with significant results in the interaction analysis, potentially explaining why nutrition may only show little beneficial results in patients with high severity of illness [15,50].…”