Admission Serum Uric Acid Levels and In-Hospital Outcomes in Patients with Acute Coronary Syndrome

Abdullah, Abm; Begum, Noortaj; Khan, Aminul Haque; Hossain, Mofazzal; Kabir, Shah Mohd Eftar Jahan; Alam, Mohammad Sarwar; Chowdhury, Abdul Wadud; Khan, HI Lutfur Rahman

doi:10.3329/jemc.v5i1.21492

Cited by 3 publications

(7 citation statements)

References 41 publications

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“…Similar finding was found by Dharma et al 13 Significant difference was observed by Bickel et al 19 and Omidver et al 14 Confounding variables such as hypertension, diabetes mellitus, smoking, dyslipidaemia and family history of IHD were not significant between high and normal serum uric acid level patients. Similar findings observed by Dharma et al 13 and Abdullah et al 24 Lim et al 25 found no significant relationship between hypertension and smoking with patients of CAD having high uric acid. Bae et al 26 showed no significant relationship between hypertension, diabetes mellitus, dyslipidaemia with patients of high serum uric acid having CAD.…”

Section: Results: 115 Patients Were Included In This Studysupporting

confidence: 81%

“…There was no significant difference of mean BMI between high and normal serum uric acid level patients. Omidvar et al 14 and Abdullah et al 24 found similar finding. Significant association between mean BMI and high uric acid observed by Bickel et al 19 and Timoteo et al 15 There was no significant difference of confounding variables between high and normal serum uric acid level patients.…”

Section: Results: 115 Patients Were Included In This Studymentioning

confidence: 56%

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Prevalence of High Serum Uric Acid in Patients with Acute Myocardial Infarction in Rajshahi Medical College Hospital

Sardar

Amin²,

Hasan³

et al. 2022

TAJ: J of Teachers Assoc

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Coronary artery disease is one of the commonest causes of death of our hospitalized patients. It has a number of risk factors such as age, sex, family history, smoking, hypertension, diabetes, dyslipidemia and obesity. Serum uric acid appears to be another risk factor found in several researches. This study was done to find out the prevalence of high serum uric acid in hospitalized acute myocardial infarction patients. This was a descriptive cross-sectional study carried out in department of Cardiology, Rajshahi medical college hospital from January 2015 to December 2016. 115 (one hundred fifteen) AMI patients were included. Baseline characteristics such as age, sex, body mass index, blood pressure, risk factors-hypertension, diabetes mellitus, smoking, family history of IHD, dyslipidemia was recorded. We measured serum uric acid of this patient at admission. Out of 115 patients, 83.5% were male and 16.5% were female. Among risk factors 65.2% had history of hypertension, 20.9% diabetes mellitus, 64.3% smoking, 16.5% family history of IHD and 47.8% dyslipidemia. Out of 115 patients, 35.7% had high serum uric acid and 64.3% had normal serum uric acid. There was no significant difference of confounding variables between high and normal serum uric acid level patients. We found larger number of AMI patients with high serum uric acid. So, high serum uric acid may be a risk factor for acute myocardial infarction. TAJ 2021; 34: No-2: 102-107

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Section: Results: 115 Patients Were Included In This Studysupporting

confidence: 81%

Section: Results: 115 Patients Were Included In This Studymentioning

confidence: 56%

Prevalence of High Serum Uric Acid in Patients with Acute Myocardial Infarction in Rajshahi Medical College Hospital

Sardar

Amin²,

Hasan³

et al. 2022

TAJ: J of Teachers Assoc

View full text Add to dashboard Cite

show abstract

“…Lazzeri et al 28 studied 466 STEMI patients, and Car et al 29 assessed 621 AMI patients and showed in-hospital mortality was higher in patients with elevated uric acid. Death was not significant in hyperuricaemic patients as in normouricemic patients observed by Culleton et al 13 and Abdullah et al 27 Our study provided a significant association between high serum uric acid level on admission and poor in-hospital outcomes like acute LVF and death in AMI of hospitalized patients. The measurement of serum uric acid levels, an easily available, cheap biochemical tool, might be used as a valuable risk marker for detection and prevention of in-hospital outcomes in AMI patients.…”

Section: Discussionsupporting

confidence: 53%

“…Cardiogenic shock was not significantly higher in patients with higher serum uric acid levels than patients with normal uric acid levels. Abdullah et al 27 studied 93 ACS patients and found similar findings. Ndrepepa et al 23 and Chen et al 25 found a significant association between cardiogenic shock and high serum uric acid.…”

Section: Discussionmentioning

confidence: 59%

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Serum Uric Acid as a Prognostic Factor of Acute Myocardial Infarction in Hospitalized Patients

Sardar

Rahman

Alam

et al. 2021

TAJ: J of Teachers Assoc

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Background: Among non-communicable diseases, acute myocardial infarction (AMI) is a common killer of people in the world. The management of AMI patients is one of the major challenges in the field of cardiology. Uric acid has several effects of potential interest in cardiovascular disease. There are some markers indicating an unfavorable prognosis in AMI patients. Uric acid is one of the markers that have been evaluated in research. Objective: The aim of this study was to assess the association between serum uric acid level and in-hospital outcomes of AMI patients. Patients and methods: This longitudinal descriptive study was conducted over 115 AMI patients in the Cardiology Unit of Rajshahi Medical College Hospital during the period of January 2015 to December 2016. Baseline characteristics such as age, sex, BMI, BP, RBS, risk factors (hypertension, DM, smoking, family history of IHD, dyslipidemia), and outcomes of AMI patients (acute LVF, arrhythmia, conduction block, cardiogenic shock, death) were recorded. We measured the serum uric acid of this patient at admission. Results: The mean age of patients was 52.83±10.71 years. Out of 115 patients, 83.5% were male, and 16.5% were female. Among the risk factors, 65.2% of patients had HTN, 20.9% DM, 64.3% smoking, 16.5% family history of IHD, and 47.8% dyslipidemia. Out of 115, 35.7% of patients demonstrated high serum uric acid. In outcomes of AMI patients, acute LVF 24.4% (p=0.031) and death 12.2% (p=0.041) were significantly higher in patients with high serum uric acid levels. Conclusion: Significant association was found between high serum uric acid level and in-hospital outcomes of AMI patients. So, estimation of serum uric acid may offer an inexpensive, quick, and non-invasive method for identifying such high-risk patients. TAJ 2021; 34: No-1: 26-32

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Frequency of Hyperuricemia in Subjects With Unstable Angina/Myocardial Infarction and Their Prognosis

Amir Rashid Qureshi,

Ali,

Mir Jalal

et al. 2022

J Ayub Med Coll Abbottabad

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Background: Inhibition of nitric oxide synthesis and stimulation of smooth muscle proliferation by increased serum levels of uric acid play an important role in accelerated atherogenesis in the vessels of patients with hyperuricemia. The objective of the study was to determine the frequency of hyperuricemia in patients with acute coronary syndrome and their in-hospital outcomes. Methods: This cross-sectional study was conducted in the cardiology department of Ayub Teaching Hospital, Abbottabad from 1st September, 2018 to 28th February, 2019. A total of 199 patients diagnosed with acute coronary syndrome (ACS) were enrolled in this study using non-probability consecutive sampling. Diagnosis of ACS was made on history, electrocardiogram (ECG) findings and on the presence of elevated cardiac biomarkers. Serum uric acid was checked within 24 hours of presentation and patients were grouped into hyperuricemic and normouricemic groups according to uric acid levels. Next in-hospital outcomes were compared between the two groups by comparing the presence or absence of complications. The data was collected on a structured proforma and was analyzed statistically by using SPSS version 16. Results: Out of 199 patients, 146 (73.37%) were male and 53 (26.63%) were female. The mean age of the study participants was 57.99 ± 6.07 years with a range of 48-68 years. Hyperuricemia was diagnosed in 50 (25.13%) study participants. Among complications, 15 patients (7.94%) had cardiogenic shock, 27 (13.57%) had heart failure, 10 (5.03%) had cardiac arrhythmias, 16 (8.04%) had conduction defects and hyperuricemia was diagnosed in 50 (25.13%) patients. Cardiogenic shock was more common in patients with hyperuricemia (p < 0.05). Conclusion: Hyperuricemia is associated with a number of significant adverse outcomes for patients with an acute coronary event. Regular screening / monitoring of serum uric acid level in general population can prevent the direct and indirect morbidity associated with hyperuricemia. Keywords: Acute coronary Syndrome, Hyperuricemia, Uric Acid, cardiogenic shock, mortality, ST elevation myocardial infarction (STEMI), non ST elevation acute coronary syndrome (NSTE-ACS)

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Admission Serum Uric Acid Levels and In-Hospital Outcomes in Patients with Acute Coronary Syndrome

Cited by 3 publications

References 41 publications

Prevalence of High Serum Uric Acid in Patients with Acute Myocardial Infarction in Rajshahi Medical College Hospital

Prevalence of High Serum Uric Acid in Patients with Acute Myocardial Infarction in Rajshahi Medical College Hospital

Serum Uric Acid as a Prognostic Factor of Acute Myocardial Infarction in Hospitalized Patients

Frequency of Hyperuricemia in Subjects With Unstable Angina/Myocardial Infarction and Their Prognosis

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