Admixture, migrations, and dispersals in Central Asia: evidence from maternal DNA lineages

Comas, David; Plaza, Stéphanie; Wells, R. Spencer; Yuldaseva, Nadira; Lao, Oscar; Calafell, Francesc; Bertranpetit, Jaume

doi:10.1038/sj.ejhg.5201160

Cited by 148 publications

(152 citation statements)

References 47 publications

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“…The Kazakh ethnic group resulted from genetic mixing of Caucasians and East Asians. [61][62][63] The genetic contribution of Caucasian in Chinese Kazakhs is 30.2% (see ref. 62).…”

Section: Discussionmentioning

confidence: 99%

α-adducin Gly460Trp polymorphism and essential hypertension risk in Chinese: a meta-analysis

Liu

et al. 2011

Hypertens Res

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No clear consensus has been reached on the a-adducin polymorphism (Gly460Trp) and essential hypertension (EH) risk in Chinese. We conducted a meta-analysis in an effort to systematically explore the possible association. Case-control studies in Chinese and English performed with human subjects were identified by searching the MEDLINE, EMBASE, China Biological Medicine Database, China National Knowledge Infrastructure platform, Wanfang and VIP databases. The fixed-effects model and the random-effects model for dichotomous outcomes were applied to combine the results of the individual studies. We selected 20 studies that met the inclusion criteria, including a total of 5562 patients with hypertension and 4289 controls. Overall, our findings supported the hypothesis that the ADD1 Gly460Trp polymorphism is associated with EH in the Chinese population. A borderline association was found between the tryptophan (Trp) allele of the Gly460Trp variant and hypertension (P¼0.05, Odds ratio (OR)¼1.08, 95% confidence interval (CI)¼1.00-1.17 and P heterogeneity ¼0.02). Significantly increased risk was observed in the recessive genetic model (P¼0.0009, OR¼1.24, 95% CI¼1.09-1.41 and P heterogeneity ¼0.04) as well as in the homozygote comparison (P¼0.006, OR¼1.25, 95% CI¼1.07-1.46 and P heterogeneity ¼0.03). Furthermore, in the subgroup analysis, our results support a positive association among Chinese Han individuals (P¼0.001, OR¼1.25, 95% CI¼1.09-1.42, P heterogeneity ¼0.08, recessive genetic model; P¼0.009, OR¼1.26, 95% CI¼1.06-1.50, P heterogeneity ¼0.03, homozygote comparison). No apparent association was identified in Kazakhs. Our meta-analysis suggests that the Gly460Trp polymorphism might increase the risk of hypertension in Chinese populations, especially in Han Chinese. Further studies investigating gene-gene, gene-environment and mutual interactions are needed to better understand the role of ADD1 in hypertension.

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“…The Kazakh ethnic group resulted from genetic mixing of Caucasians and East Asians. [61][62][63] The genetic contribution of Caucasian in Chinese Kazakhs is 30.2% (see ref. 62).…”

Section: Discussionmentioning

confidence: 99%

α-adducin Gly460Trp polymorphism and essential hypertension risk in Chinese: a meta-analysis

Liu

et al. 2011

Hypertens Res

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“…Altogether, these results indicate that the genetic pool of NEAS is related to that of CAS and exhibits signatures of gene flow from multiple sources, while that of SEAS indicates greater isolation and population subdivision, although with a low level of differentiation among populations. Another crucial result related to these observations is the very high level of genetic diversity found in Central Asian populations (Comas et al 1998(Comas et al , 2004Hammer et al 2001;Quintana-Murci et al 2004;Wells et al 2001;Zerjal et al 2002), compatible with their connection to NEAS through gene flow, Central Asia being considered either as a source or as a receiver (Comas et al 1998(Comas et al , 2004Quintana-Murci et al 2004;Zerjal et al 2002) of human migrations.…”

Section: North and South Substructuresmentioning

confidence: 92%

A Genetic Focus on the Peopling History of East Asia: Critical Views

Sanchez‐Mazas

Riccio

2011

Rice

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Population genetic studies may provide crucial information for our knowledge on human peopling history and have been extensively applied to reconstruct East Asian prehistory in the last 10 years. However, different genetic investigations are not always consistent with each other and some results are conflicting or misinterpreted. This represents a main obstacle for scholars of other disciplines like archaeologists and linguists who try to relate the genetic information on past human migrations to their own results on the spread of domesticated crops or animals or on the dispersal of the main language families. In this paper, we review the current genetic evidence related to the peopling history of East Asia with a critical view on some interpretations. In this way, we hope to provide a useful reference for further interdisciplinary studies on our past.

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“…The results of the MDS (Figure 2) suggest that geography can explain the grouping of populations on the two-dimensional plot. Sagalassos is located very close to the samples from Turkey, Crimea and Iran, [34][35][36] which present a nonsignificant differentiation with Sagalassos (Fsto0.01) (Supplementary Table 8) and their position in the middle of the plot reflects a geographic bridge between Asia and Europe. Regarding Asian populations, a genetic proximity in the MDS plot of some Uzbek samples (Fsto0.01) to Sagalassos has been observed.…”

Section: Population Comparisonsmentioning

confidence: 98%

Mitochondrial analysis of a Byzantine population reveals the differential impact of multiple historical events in South Anatolia

Ottoni¹,

Ricaut²,

Vanderheyden³

et al. 2011

Eur J Hum Genet

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The archaeological site of Sagalassos is located in Southwest Turkey, in the western part of the Taurus mountain range. Human occupation of its territory is attested from the late 12th millennium BP up to the 13th century AD. By analysing the mtDNA variation in 85 skeletons from Sagalassos dated to the 11th–13th century AD, this study attempts to reconstruct the genetic signature potentially left in this region of Anatolia by the many civilizations, which succeeded one another over the centuries until the mid-Byzantine period (13th century BC). Authentic ancient DNA data were determined from the control region and some SNPs in the coding region of the mtDNA in 53 individuals. Comparative analyses with up to 157 modern populations allowed us to reconstruct the origin of the mid-Byzantine people still dwelling in dispersed hamlets in Sagalassos, and to detect the maternal contribution of their potential ancestors. By integrating the genetic data with historical and archaeological information, we were able to attest in Sagalassos a significant maternal genetic signature of Balkan/Greek populations, as well as ancient Persians and populations from the Italian peninsula. Some contribution from the Levant has been also detected, whereas no contribution from Central Asian population could be ascertained

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Admixture, migrations, and dispersals in Central Asia: evidence from maternal DNA lineages

Cited by 148 publications

References 47 publications

α-adducin Gly460Trp polymorphism and essential hypertension risk in Chinese: a meta-analysis

α-adducin Gly460Trp polymorphism and essential hypertension risk in Chinese: a meta-analysis

A Genetic Focus on the Peopling History of East Asia: Critical Views

Mitochondrial analysis of a Byzantine population reveals the differential impact of multiple historical events in South Anatolia

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