Adnexal and Sebaceous Carcinomas

Seger, Edward W.; Neill, Brett C.; Tolkachjov, Stanislav N.

doi:10.1016/j.det.2022.07.010

Cited by 3 publications

(1 citation statement)

References 94 publications

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“…Sweat gland cancer is a very rare skin cancer, accounts for only 0.05% of skin cancers overall. 1,2 According to medical literature, the common age is the middle-aged group of 50 -70 years. 3,4 Common location of sweat gland cancer is in the head, face, neck.…”

Section: Introductionmentioning

confidence: 99%

Malignant Sweat Gland Tumours: A Case Series

Hoang Quoc,

Le Thi Hai,

Nguyen Hong

et al. 2024

TC DLH VN

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Objectives: Malignant sweat gland tumor is a very rare skin cancer with variable presentations. The objectives of this study are to examine the clinicopathological and immunohistochemical features of malignant sweat gland tumors and to discuss the treatment and follow-up for postsurgical recurrence rates. Methods: Six patients diagnosed with sweat gland carcinoma at the National Hospital of Dermatology and Venereology between 2018 and 2023 were carefully reviewed. Results: The cases occurred in four men and two women, ranging in age from 31 to 78 years (mean 59.3). Four of the lesions were from the scalp, one from the nose, and one from the right arm. There were three cases of Eccrine Porocarcinoma, two cases of Hidradenocarcinoma, and one case of Syringoid Eccrine Carcinoma. All of them were treated with surgery, five cases with wide local excision, and one case with Mohs micrographic surgery. Only one case had a recurrence. Conclusion: Malignant sweat gland tumors demonstrate significant variability in clinicopathology and immunohistopathology. Surgery is the mainstay of treatment. Received 28 June 2023Revised 26 September 2023Accepted 29 November 2023

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Section: Introductionmentioning

confidence: 99%

Malignant Sweat Gland Tumours: A Case Series

Hoang Quoc,

Le Thi Hai,

Nguyen Hong

et al. 2024

TC DLH VN

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Challenges in the diagnosis and treatment of the malignant adnexal neoplasms of the head and neck

Wierzbicka

Kraiński

Bartochowska

2023

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of reviewThe current review is to present the current knowledge regarding epidemiology, diagnostics, and management of malignant adnexal neoplasms (MANs).Recent findingsImmunotherapy and gene-related therapies are still being developed as the methods of salvage treatment in advanced and disseminated cases: CACNA1S, ATP2A1, RYR1, and MYLK3, as well as p53 or the JAK/STAT pathways, may be therapeutic targets; the efficiency of talimogene laherparepvec and nivolumab is assessed.SummaryMANs are rare tumors, but due to the aging of population their incidence is increasing. Their clinical presentation is unspecific, which makes the diagnosis challenging. Histopathological assessment is difficult even for experienced pathologists. Mohs micrographic surgery or wide local excision are recommended to treat primary lesions. Adjuvant radiotherapy may be beneficial in case of insufficient or positive surgical margins, in nodal metastases, in selected types of MANs like sebaceous, trichilemmal, and pilomatrix carcinomas, and as the induction treatment in large tumors located in medically fragile or cosmetically important regions. The role of chemotherapy is not well defined; however, it is recommended in distant metastases. Immunotherapy can improve the prognosis in advanced stage of the disease.

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Treatment of sebaceous carcinoma with Mohs micrographic surgery versus wide local excision: a systematic review

Yadlapati,

Rosa‐Nieves,

Mehta

et al. 2024

Int J Dermatology

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Sebaceous carcinoma (SC) is a rare neoplasm affecting periocular and extraocular sites. If inadequately treated, it can recur and cause morbidity. Specific management guidelines have not been established. Wide local excision (WLE) has been traditionally used; however, Mohs micrographic surgery (MMS) can be advantageous because of complete margin assessment and tissue‐sparing nature. This analysis aims to systematically review the surgical modalities used for the management of SC. Articles meeting eligibility criteria were identified using MEDLINE (via PubMed), Embase, Cochrane, and Scopus databases. All studies investigating surgical management of SC with WLE or MMS were considered. Seventy studies met inclusion criteria, including retrospective cohort studies, case series, and case reports. WLE was used in 32 studies, MMS in 29, and MMS and WLE in 9. Subgroup analysis showed that MMS has lower recurrence rates. For WLE, local, regional, and distant recurrence rates were 23.4%, 13.3%, and 11.0%, respectively, and for MMS, 6.8%, 4.3%, and 4.6%, respectively. Patients treated with WLE were more likely to have local recurrence than patients treated with MMS (P = 0.001). WLE cases were more likely to have a regional (P = 0.05) and distant recurrence (P = 0.001). Limitations of the study include heterogeneity of case reports, case series, and retrospective studies, variable follow‐up times between the two groups, and large tumors included in the WLE category. In addition, disease‐specific survival was not evaluated. MMS cases showed a superior outcome for local, regional, and distant recurrence, making it a good option for the management of SC.

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Adnexal and Sebaceous Carcinomas

Cited by 3 publications

References 94 publications

Malignant Sweat Gland Tumours: A Case Series

Malignant Sweat Gland Tumours: A Case Series

Challenges in the diagnosis and treatment of the malignant adnexal neoplasms of the head and neck

Treatment of sebaceous carcinoma with Mohs micrographic surgery versus wide local excision: a systematic review

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