Depression and anxiety symptoms are increasingly common in the world population and may damage different aspects of life. In the school context, these symptoms may affect teachers' self-esteem and educational social skills. This study aimed to evaluate and compare depression and anxiety symptoms, self-esteem and educational social skills in first and last grades elementary public school teachers, with 196 teachers, men and women, aged 18 years or older. The instruments applied were: a sociodemographic questionnaire, State-Trait Anxiety Inventory (STAI), Population Screening Scale for Depression Epidemiological Studies Center (CES-D), Depressive Symptoms Intensity Survey (LIS-D), the Anxiety Symptoms Intensity Survey (LIS-A), the Rosenberg Self-Esteem Scale (RSES), and the Inventory of Educational Social Skills-Teachers (IHSE). The main results indicate differences between the two teachers' groups regarding the levels of depressive and anxiety symptoms, some educational social skills and self-esteem. Future studies with teachers should consider specific aspects of teaching work.