Adolescence and the next generation

Patton, George C.; Olsson, Craig A.; Skirbekk, Vegard; Saffery, Richard; Wlodek, Mary E.; Azzopardi, Peter; Stonawski, Marcin; Rasmussen, Bruce; Spry, Elizabeth; Francis, Kate; Bhutta, Zulfiqar A; Kassebaum, Nicholas J; Mokdad, Ali H.; Murray, Christopher J L; Prentice, Andrew M.; Reavley, Nicola; Sheehan, Peter; Sweeny, Kim; Viner, Russell; Sawyer, Susan Μ

doi:10.1038/nature25759

Cited by 288 publications

(254 citation statements)

References 136 publications

(143 reference statements)

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“…This is important since some of the youth‐onset cases may have started symptoms before the age of 12, therefore fulfilling DSM‐5 age of onset criteria. On the other hand, this limitation does not contradict core findings of our research regarding dimensionality and cognitive impairments, even more considering that the very concept of youth is being expanded to cover from 10 to 24 years old (Patton et al., ), a time interval in which our YO cases do apply. Nonetheless, we performed a sensitivity analysis for a subsample of 11–12 years old at baseline, assuring that ADHD incidence would occur after 12 years old.…”

Section: Discussionmentioning

confidence: 63%

Heterotypic trajectories of dimensional psychopathology across the lifespan: the case of youth‐onset attention deficit/hyperactivity disorder

Manfro

Santoro

Polanczyk

et al. 2018

Child Psychology Psychiatry

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Background Recent studies have demonstrated the existence of a distinct late‐onset attention deficit/hyperactivity disorder (ADHD) trajectory. Our objective is to test if there are distinct ADHD trajectories regarding age of onset from childhood to adolescence and to compare clinical manifestations, cognitive functions and genetic risk for ADHD among distinct longitudinal groups. Method Nine hundred and twenty four children and adolescents from the community participated in the study. We compared clinical, cognitive features and genetic risk among four groups of participants: (a) childhood‐limited, (b) youth‐onset, (c) childhood‐onset with youth persistence, and (d) community comparisons without ADHD. Symptomatic and diagnostic assessments were performed using the Development and Well‐Being Behavior Assessment, the Strengths and Difficulties Questionnaire, and the Child Behavior Checklist. Cognitive functions were measured using a battery of standardized tests. Genetic risk for ADHD was calculating using summary statistics from the Psychiatric Genomics Consortium. Results Half of the adolescents (52%) with ADHD had their symptom onset in adolescence. The impairment level of this group in adolescence is similar to the persistent group. Despite not having ADHD, the youth‐onset group already presented in childhood more symptoms from other domains of psychopathology, higher shared variance in psychiatric symptomatology (p‐factor), school impairment, and executive dysfunctions than community comparisons. Furthermore, the youth‐onset group presented lower levels of genetic risk for ADHD compared to other cases. Conclusions A significant proportion of adolescents with ADHD were youth‐onset cases and presented similar impairment levels as those cases with early‐onset ADHD. The presence of cognitive impairments and higher levels of clinical symptoms in the youth‐onset group already at childhood speaks in favor of a heterotypic trajectory of psychopathology suggesting that youth‐onset ADHD might be an artificial consequence of categorizing dimensional psychopathology into discrete diagnostic groups.

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Section: Discussionmentioning

confidence: 63%

Heterotypic trajectories of dimensional psychopathology across the lifespan: the case of youth‐onset attention deficit/hyperactivity disorder

Manfro

Santoro

Polanczyk

et al. 2018

Child Psychology Psychiatry

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“…Adolescence is a transitional period in the life cycle characterized by physical, social, and developmental changes that influence health and eating behaviour. Starting at the onset of puberty and continuing to young adulthood, the World Health Organization (WHO) defines adolescence as between 10 and 19 years of age, with the period commonly divided into early (10–14 years) and late (15–19 years) adolescence (Black et al, ; G. C. Patton et al, ). During this period, rapid growth and dramatic physical changes create increased demand for nutrients and energy as simultaneously, adolescents undergo many psychosocial changes, such as seeking independence and self‐identity and growing concerns about body image, all of which can impact on food selection and nutritional intake (Das et al, ; Story, Neumark‐Sztainer, & French, ).…”

Section: Introductionmentioning

confidence: 99%

In‐depth assessment of snacking behaviour in unmarried adolescent girls 16–19 years of age living in urban centres of Java, Indonesia

Blum

Mellisa²,

Sari

et al. 2019

Maternal & Child Nutrition

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Adolescence is a critical period characterized by physical, social, and developmental changes that impact on health and eating behaviour. Indonesia is experiencing dramatic economic and infrastructural changes, causing greater access to the global food industry and media. This transition is influencing food intake trends, leading to new nutritional challenges in adolescent girls. Qualitative research was conducted between November 2016 and January 2017 in five urban sites in Java, Indonesia, to examine individual, social, environmental, and macrosystem factors affecting snacking behaviours in unmarried adolescent girls 16–19 years of age. Methods entailed 30 freelisting exercises, nine key informant interviews, and 16 in‐depth interviews. Freelisting results identified over 200 snack foods, with the most salient processed convenience foods such as chips and cookies. Respondents typically snacked multiple times daily. Widespread availability of affordable and “tasty” snacks makes snack foods appealing meal substitutes. Snacks provide a distraction to boredom and loneliness and an enhancement to social gatherings. Girls exhibited limited understanding or concern about potential negative effects of snacking. Parents facilitate acquisition of nutrient‐poor snacks, whereas friends exert pressure for routine consumption of snack foods. Social media infiltrated with promotions of eateries and snack foods is likely contributing to the preponderance of snack food consumption. Routine consumption of snack foods high in sugar, salt, and fat and skipping meals will likely have long‐term consequences on the nutritional status and health of Indonesian adolescent girls. Findings underline the urgent need to develop contextually relevant, targeted behavioural change strategies to modify the potentially harmful eating and activity patterns of adolescent girls identified in this study and to curb the trajectory of overweight in urban Indonesia.

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“…4 The most significant risk factor for developing GDM is being overweight/obese 5,6 ; hence, there is a fourfold to ninefold increase in GDM frequency in obese women. 10 We have additionally highlighted that exercise prior to planning a pregnancy may be important for maternal and offspring health. Exercise is effective in improving maternal glucose control in some, but not all, women [7][8][9] suggesting that interventions during pregnancy alone may not be sufficient to ameliorate disease risk.…”

Section: Introductionmentioning

confidence: 99%

Exercise improves metabolic function and alters the microbiome in rats with gestational diabetes

et al. 2019

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are Co-senior authors.Abbreviations: ANOVA, analysis of variance; E, embryonic day; Exercise, Exercise before and during pregnancy; GDM, gestational diabetes mellitus; HFD, high-fat diet; PPARγ, peroxisome proliferator-activated receptor gamma; PregEx, Exercise during pregnancy only; qPCR, quantitative polymerase chain reaction; RNA, ribonucleic acid; SRY, sex-determining region y; X-TOT, total number of x-axis beam breaks. AbstractGestational diabetes mellitus (GDM) is a common pregnancy complication, particularly prevalent in obese women. Importantly, exercise has beneficial impacts on maternal glucose control and may prevent GDM in "at-risk" women. We aimed to determine whether a high-fat diet (HFD) exacerbates metabolic dysfunction and alters gut microbiome in GDM and whether endurance exercise prevents these changes. Uteroplacental insufficiency was induced by bilateral uterine vessel ligation (Restricted) or sham (Control) surgery on E18 in Wistar-Kyoto rats. Female offspring were fed a Chow or HFD (23% fat) from weaning (5 weeks) and at 16 weeks randomly allocated to remain Sedentary or to an exercise protocol of either Exercise prior to and during pregnancy (Exercise); or Exercise during pregnancy only (PregEx). Females were mated (20 weeks) and underwent indirect calorimetry (embryonic day 16; E16), glucose tolerance testing (E18), followed by 24-hr feces collection at E19 (n = 8-10/group). HFD consumption in female rats with GDM exacerbated the adverse metabolic adaptations to pregnancy and altered gut microbial populations. Specifically, the Firmicutes-to-Bacteroidetes ratio was increased, due to an underlying change in abundance of the orders Clostridiales and Bacteroidales.Maternal Exercise, but not PregEx, prevented the development of metabolic dysfunction, increased pancreatic β-cell mass, and prevented the alteration of the gut microbiome in GDM females. Our findings suggest that maternal exercise and diet influence metabolic and microbiome dysfunction in females with GDM, which may impact long-term maternal and offspring health. K E Y W O R D S exercise training, fetal programming, gestational diabetes, microbiome, obesity, pregnancy adaptations How to cite this article: Mahizir D, Briffa JF, Wood JL, et al. Exercise improves metabolic function and alters the microbiome in rats with gestational diabetes.

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Adolescence and the next generation

Cited by 288 publications

References 136 publications

Heterotypic trajectories of dimensional psychopathology across the lifespan: the case of youth‐onset attention deficit/hyperactivity disorder

Heterotypic trajectories of dimensional psychopathology across the lifespan: the case of youth‐onset attention deficit/hyperactivity disorder

In‐depth assessment of snacking behaviour in unmarried adolescent girls 16–19 years of age living in urban centres of Java, Indonesia

Exercise improves metabolic function and alters the microbiome in rats with gestational diabetes

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