Adolescence, the Microbiota-Gut-Brain Axis, and the Emergence of Psychiatric Disorders

McVey Neufeld, Sadie F.; Ahn, Matthew; Kunze, Wolfgang A.; McVey Neufeld, Karen-Anne

doi:10.1016/j.biopsych.2023.10.006

Cited by 8 publications

(4 citation statements)

References 116 publications

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“…Finally, the highs' ability to modulate their autonomic activity [83,90,91], challenged by only one study [92] could positively influence their microbiota, whose alteration is involved in cognitive decline owing to the cerebral effects of locally produced cytokines and the activation of afferent vagal fibers [93]. The negative effects of microbiota alteration of have been described, in fact, in case of degenerative physical and cognitive decline [94][95][96][97][98][99][100].…”

Section: Cardiovascular Controlmentioning

confidence: 99%

Physiological Correlates of Hypnotizability: Hypnotic Behaviour and Prognostic Role in Medicine

Malloggi,

Santarcangelo

2023

Brain Sciences

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Studies in the field of experimental hypnosis highlighted the role of hypnotizability in the physiological variability of the general population. It is associated, in fact, with a few differences which are observable in the ordinary state of consciousness and in the absence of suggestions. The aim of the present scoping review is summarizing them and indicate their relevance to the neural mechanisms of hypnosis and to the prognosis and treatment of a few medical conditions. Individuals with high, medium and low hypnotizability scores display different cerebral functional differences—i.e., functional equivalence between imagery and perception/action, excitability of the motor cortex, interoceptive accuracy—possibly related to brain structural and functional characteristics, and different control of blood supply at peripheral and cerebral level, likely due to different availability of endothelial nitric oxide. These differences are reviewed to support the idea of their participation in hypnotic behaviour and to indicate their prognostic and therapeutic usefulness in a few medical conditions.

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Section: Cardiovascular Controlmentioning

confidence: 99%

Physiological Correlates of Hypnotizability: Hypnotic Behaviour and Prognostic Role in Medicine

Malloggi,

Santarcangelo

2023

Brain Sciences

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“…Several mechanisms are implicated in regulating the GBM axis, including the hypothalamic–pituitary–adrenal axis (HPA), microbial metabolites, hippocampal neurogenesis, neuronal pathways (via the vagus nerve), neuroactive pathways (serotonin and neuroactive metabolites), the kynurenine pathway, and immune pathways ( 9 ). Importantly, recent findings suggest a unique vulnerability in the gut microbiota (GM) during the period of emerging adulthood ( 10 – 12 ). The GM regulates the integrity of the intestinal membrane and inflammation along the gastrointestinal tract ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

“…There is strong theoretical rationale linking food intake and mental health as being mediated through the GBM ( 12 ). The prevalence of a less nutrient-rich and more processed diet with numerous additives may well be predisposing whole segments of the human population to poor mental health, starting at a young age.…”

Section: Introductionmentioning

confidence: 99%

“…Food intake and the GBM may also play an important role as a precipitating factor for mental illnesses in EAs, made vulnerable by the instability of the GBM in adolescence and young adulthood, a period during which most mental illnesses have their onset ( 10 , 11 ). Several studies and reviews over the past decade have explored the GBM axis and the complex bidirectional relationship between diet and mental health ( 14 , 45 – 47 ), including among adolescents ( 12 ). In the context of EAs, this relationship is particularly complex, since eating behaviors, experimentation with substances and hormonal states are often irregular during this developmental stage.…”

Section: Introductionmentioning

confidence: 99%

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Predispose, precipitate, perpetuate, and protect: how diet and the gut influence mental health in emerging adulthood

Warren,

O’Connor,

Lee

et al. 2024

Front. Nutr.

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Medicine often employs the 4Ps of predisposing, precipitating, perpetuating, and protective factors to identify salient influences on illness states, and to help guide patient care. Mental illness is a significant cause of morbidity and mortality worldwide. Mental health is a complex combination of biological, psychological, environmental, and social factors. There is growing interest in the gut-brain-microbiome (GBM) axis and its impact on mental health. We use the medical model of the 4Ps to explore factors involving the connection between nutrition and the GBM axis and their associated risks with mental health problems in emerging adults (EAs), a life stage when mental illness onset is the most common. We review the impact of current dietary trends on the GBM and on mental health, and the role that gut microbiome-based interventions can have in modulating the GBM axis of EAs. We discuss the implications of gut health on the GBM and areas for clinical intervention.

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Lactobacillus paracasei Jlus66 relieves DSS-induced ulcerative colitis in a murine model by maintaining intestinal barrier integrity, inhibiting inflammation, and improving intestinal microbiota structure

Yu,

Wang,

Ren

et al. 2024

Eur J Nutr

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Adolescence, the Microbiota-Gut-Brain Axis, and the Emergence of Psychiatric Disorders

Cited by 8 publications

References 116 publications

Physiological Correlates of Hypnotizability: Hypnotic Behaviour and Prognostic Role in Medicine

Physiological Correlates of Hypnotizability: Hypnotic Behaviour and Prognostic Role in Medicine

Predispose, precipitate, perpetuate, and protect: how diet and the gut influence mental health in emerging adulthood

Lactobacillus paracasei Jlus66 relieves DSS-induced ulcerative colitis in a murine model by maintaining intestinal barrier integrity, inhibiting inflammation, and improving intestinal microbiota structure

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