Adolescent activity-based anorexia increases anxiety-like behavior in adulthood

Kinzig, Kimberly P.; Hargrave, Sara L.

doi:10.1016/j.physbeh.2010.05.010

Cited by 34 publications

(37 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, plasma corticosterone, the main rodent glucocorticoid, is elevated in animals undergoing the ABA protocol [80]. A history of ABA exposure during adolescence has been shown to have long-term influence on anxiety-like behavior and neuroendocrine measures of HPA axis activation in adult female rats that have returned to a normal body weight [66]. These animals demonstrated persistent elevations in plasma corticosterone and…”

Section: Exercise and Caloriementioning

confidence: 99%

Anorexia nervosa as a motivated behavior: Relevance of anxiety, stress, fear and learning

Guarda¹,

Schreyer²,

Boersma³

et al. 2015

Physiology & Behavior

View full text Add to dashboard Cite

Section: Exercise and Caloriementioning

confidence: 99%

Anorexia nervosa as a motivated behavior: Relevance of anxiety, stress, fear and learning

Guarda¹,

Schreyer²,

Boersma³

et al. 2015

Physiology & Behavior

View full text Add to dashboard Cite

“…During the acquisition trial there were no significant differences between ABA and SED rats in the total time spent exploring an object (t(15)=0.902, df=8, p=0.382). The rats did not display a clear preference for either object (Chi-Square=7.228, df=8, p=0.370).…”

Section: Resultsmentioning

confidence: 91%

“…The rats did not display a clear preference for either object (Chi-Square=7.228, df=8, p=0.370). During the novel object recollection trial, no statistical differences in total time spent exploring an object were observed (t(15)=1.618, p=0.126). However, ABA rats spent significantly less time exploring the novel object compared to SED rats (t(15)=−4.831, p<0.001).…”

Section: Resultsmentioning

confidence: 91%

“…During the novel object recollection trial, no statistical differences in total time spent exploring an object were observed (t(15)=1.618, p=0.126). However, ABA rats spent significantly less time exploring the novel object compared to SED rats (t(15)=−4.831, p<0.001). Chi-square analysis revealed that SED rats had a significant preference for the novel object (Chi-Square=27.230, df =8, p<0.001), whereas ABA rats did not display a clear preference (Chi-Square= 7.710, df =8, p = 0.358) (Figure 6A).…”

Section: Resultsmentioning

confidence: 91%

“…Additionally, high trait anxiety was a negative predictor for recovery success (14). In addition to these studies in humans, Kinzig and Hargrave showed that adult rats that were recovered from two bouts of ABA during adolescence displayed increased anxiety-like behavior in the elevated plus maze (EPM) test and the open field test (15). Results from a study in which performance in an EPM during ABA in mice was measured suggested that food restriction, independent of running wheel access increased open arm exploration and may thus be considered anxiolytic.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Exposure to activity‐based anorexia impairs contextual learning in weight‐restored rats without affecting spatial learning, taste, anxiety, or dietary‐fat preference

Boersma

Treesukosol

Cordner

et al. 2015

Intl J Eating Disorders

View full text Add to dashboard Cite

Relapse rates are high amongst cases of Anorexia Nervosa (AN) suggesting that some alterations induced by AN may remain after weight restoration. Objective To study the consequences of AN without confounds of environmental variability, a rodent model of activity based anorexia (ABA) can be employed. We hypothesized that exposure to ABA during adolescence may have long-term consequences in taste function, cognition, and anxiety-like behavior after weight restoration. Methods To test this hypothesis we exposed adolescent female rats to ABA (1.5 hrs food access, combined with voluntary running wheel access) and compared their behavior to that of control rats after weight restoration was achieved. The rats were tested for learning /memory, anxiety, food preference and taste in a set of behavioral tests performed during the light period. Results Our data show that ABA exposure leads to reduced performance during the novel object recognition task, a test for contextual learning, without altering performance in the novel place recognition task or the Barnes maze, both tasks that test spatial learning. Furthermore, we do not observe alterations in unconditioned lick responses to sucrose nor quinine (described by humans as “sweet” and “bitter” respectively). Nor did we find alterations in anxiety-like behavior during an elevated plus maze or an open field test. Finally, preference for a diet high in fat was not altered. Discussion Overall our data suggest that ABA exposure during adolescence impairs contextual learning in adulthood without altering spatial leaning, taste, anxiety, or fat preference.

show abstract

Sexually dimorphic behavioral effects of maternal separation in anorexic rats

Farinetti

Aspesi

Marraudino

et al. 2019

Developmental Psychobiology

View full text Add to dashboard Cite

Exposure to negative events during the neonatal period is one of the leading factors contributing to the development of psychiatric disorders, including anorexia nervosa. In this study, we investigated the effects of maternal separation (MS) on the development of anorexia in rodents using the mild‐stress form of the activity‐based anorexia (ABA) model (2 hr of free access to a running wheel and a 1‐hr feeding test) in both male and female rats. We assessed anxiety‐like and locomotor behavior and hyperactivity with the open field and elevated plus maze tests. Our results showed that ABA rats of both sexes displayed hyperactive behavior associated with reduced anxiety‐like behavior when compared to controls. However, a sexually dimorphic effect of MS emerged in anorexic rats: while the females exposed to MS + ABA were hyperactive with diminished anxiety‐related behaviors compared to females of the ABA group, MS in males attenuated or did not alter the effects of the ABA protocol. In conclusion, our data reveal that the synergistic effects of MS and ABA on physical activity and anxiety‐like behavior act in opposite directions in the two sexes.

show abstract

Adolescent activity-based anorexia increases anxiety-like behavior in adulthood

Cited by 34 publications

References 54 publications

Anorexia nervosa as a motivated behavior: Relevance of anxiety, stress, fear and learning

Anorexia nervosa as a motivated behavior: Relevance of anxiety, stress, fear and learning

Exposure to activity‐based anorexia impairs contextual learning in weight‐restored rats without affecting spatial learning, taste, anxiety, or dietary‐fat preference

Sexually dimorphic behavioral effects of maternal separation in anorexic rats

Contact Info

Product

Resources

About