Adolescent caffeine consumption increases adulthood anxiety-related behavior and modifies neuroendocrine signaling

O’Neill, Casey E.; Newsom, Ryan J.; Stafford, Jacob; Scott, Talia; Archuleta, Solana; Levis, S; Spencer, Robert L.; Campeau, Serge; Bachtell, Ryan K.

doi:10.1016/j.psyneuen.2016.01.030

Cited by 42 publications

(45 citation statements)

References 61 publications

(100 reference statements)

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“…As shown in Fig. 2D, the mice in C and S groups showed similar levels of sensitivity in the baseline, acquisition, extinction, and reinstatement of cocaine CPP in their adulthood [F (3,72) = 0.4544, P = 0.0184].…”

Section: Cocaine Enhanced Anxiety-like and Depression-like Behaviorsmentioning

confidence: 86%

“…Adolescents represents more susceptibility to substance use than adults (1) because of their immature brain and high willingness for risk-taking behaviors (2). Early exposure to drugs could result in psychiatric problems that often last for a long time, which even persist into adulthood (3)(4)(5). Our previous study found that adolescent cocaine exposure results in a prolonged modification on synapses in adult medial prefrontal cortex (mPFC) (6).…”

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confidence: 99%

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Adolescent cocaine exposure enhances the GABAergic transmission in the prelimbic cortex of adult mice

et al. 2019

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We have recently shown in rats that adolescent cocaine exposure induces prolonged modifications on synapses in medial prefrontal cortex (mPFC), which might contribute to long‐term behavioral outcomes in adulthood. In this study, we further investigated the molecular mechanisms underlying adolescent cocaine exposure‐related psychiatric problems in adulthood, especially focusing on the alterations of GABAergic transmission in prelimbic cortex (PrL), 1 subregion of mPFC. Consistent with a previous study, adolescent cocaine‐exposed mice exhibited enhanced anxiety‐like behaviors in their adulthood. In the same mice models, depression‐like behaviors increased as well, but the conditioned place preference formed normally. In parallel, activities of pyramidal neurons at layer V of PrL were reduced after adolescent cocaine exposure, accompanied by an increase in the percentage of symmetric synapses in PrL of adult mice. Additionally, miniature inhibitory postsynaptic currents rather than miniature excitatory postsynaptic currents were increased on these pyramidal neurons, and increased levels of GABA were found in adult PrL. The molecules in the GABAergic system in adult PrL were also changed by adolescent cocaine use, as indicated by increased glutamate decarboxylase 67kDa, GAB AA‐αl, and decreased GABA transporter 1. In the same mice, some regulators to GABAergic transmission such as neuregulin l/ErbB4 signals were heightened as well. Collectively, these findings revealed that adolescent cocaine exposure results in permanent enhancement of GABAergic transmission on pyramidal neurons in PrL, which subsequently attenuate the activities of these neurons and ultimately contributes to the development of psychiatric disorders in later life.—Shi, P., Nie, J., Liu, H., Li, Y., Lu, X., Shen, X., Ge, F., Yuan, T.‐F., Guan, X. Adolescent cocaine exposure enhances the GABAergic transmission in the prelimbic cortex of adult mice. FASEB J. 33, 8614–8622 (2019). http://www.fasebj.org

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Section: Cocaine Enhanced Anxiety-like and Depression-like Behaviorsmentioning

confidence: 86%

mentioning

confidence: 99%

Adolescent cocaine exposure enhances the GABAergic transmission in the prelimbic cortex of adult mice

et al. 2019

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“…Caffeine is the most commonly used psychostimulant throughout the world (O’Neill, ; Rath, ; Warzak, ). Caffeine consumption has become especially prevalent among adolescents and young adults, with over 75% of this population consuming caffeine daily (James, Kristjansson, & Sigfusdottir, ; National Sleep Foundation, ).…”

Section: Introductionmentioning

confidence: 99%

Caffeine consumption during development alters spine density and recovery from repetitive mild traumatic brain injury in young adult rats

Christensen

Yamakawa

Salberg

et al. 2019

Synapse

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Caffeine is the most commonly used psychostimulant throughout the world, with its consumption being especially prevalent among adolescents and young adults, as over 75% of this group consumes caffeine daily. Similarly, the adolescent and young adult age group exhibit the highest incidence of traumatic brain injury (TBI). Given that both caffeine consumption and mild TBI (mTBI) are more prevalent among the late adolescent/young adult age group and that changes in dendritic spine morphology during this developmental period are poorly understood, this study sought to examine the effects of caffeine consumption during late adolescence/early adulthood on recovery from repetitive mTBI (RmTBI). The study specifically focused on changes to neuronal dendritic morphology as synaptic changes likely underlie long-term behavioral outcomes. The results demonstrate that during young adulthood caffeine consumption differentially affects the RmTBI outcomes of males and females, where the effects of caffeine and RmTBI were often additive in males while being equally detrimental, but rarely additive, in females. In general, caffeine and RmTBI induced the greatest impairments in males on cognitive and motor tasks whereas in females the most significant detriments were on pain-related tasks. Both caffeine and RmTBI increased spine density in the Cg3 (medial prefrontal cortex [mPFC]), AID (orbitofrontal cortex [OFC]), and nucleus accumbens (NAc), which is proposed to reflect an impairment in the normal pruning processes. Overall, despite caffeine's neuroprotective abilities among other age groups, this study offers concerning results regarding the detrimental effects of caffeine and RmTBI, in isolation, and especially in combination, in this susceptible population. K E Y W O R D Sadolescent, behavior, concussion, dendritic morphology, Golgi-Cox staining, nucleus accumbens, prefrontal cortex

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“…Although the neural mechanism of caffeine is well-understood, the conditions under which caffeine improves cognitive and physical performance remain equivocal (6). Low to moderate doses of caffeine improve performance 37 on cognitive tasks (7)(8)(9)(10), yet higher doses may result in decrements in performance and increased negative mood or affects, such as anxiety and jitteriness (8,11). It is unclear if caffeine has primary effects on performance or whether it merely reverses a deficit in performance introduced by caffeine withdrawal (12)(13)(14).…”

mentioning

confidence: 99%

Systematic Review and Meta-analysis of the Effects of Caffeine in Fatigued Shift Workers: Implications for Emergency Medical Services Personnel

Temple¹,

Hostler²,

Martin‐Gill³

et al. 2018

Prehospital Emergency Care

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Although the quality of evidence was judged to be low to moderate, when taken together, these studies demonstrate that caffeine can improve psychomotor performance and vigilance. However, caffeine negatively affects sleep quality and sleep duration. More systematic, randomized studies need to be conducted in EMS workers in order to address the critical outcomes of health and safety of EMS personnel and patients. The risk/benefit ratio of chronic caffeine use in shift workers is currently unknown.

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Adolescent caffeine consumption increases adulthood anxiety-related behavior and modifies neuroendocrine signaling

Cited by 42 publications

References 61 publications

Adolescent cocaine exposure enhances the GABAergic transmission in the prelimbic cortex of adult mice

Adolescent cocaine exposure enhances the GABAergic transmission in the prelimbic cortex of adult mice

Caffeine consumption during development alters spine density and recovery from repetitive mild traumatic brain injury in young adult rats

Systematic Review and Meta-analysis of the Effects of Caffeine in Fatigued Shift Workers: Implications for Emergency Medical Services Personnel

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