2020
DOI: 10.1002/jdn.10028
|View full text |Cite
|
Sign up to set email alerts
|

Adolescent CB1 receptor antagonism influences subsequent social interactions and neural activity in female rats

Abstract: We previously demonstrated that repeated exposure to the CB1 receptor antagonist/inverse agonist AM251 in adolescence (PND 30–44) increased social interactions in female rats when tested 48 h after the final exposure to the antagonist. Here, we investigated whether the increased sociality would be present after a longer drug washout period (5 days) in both male and female rats (experiment 1), and sought to identify candidate brain regions that may explain the observed differences in social behaviours between A… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

0
2
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
4
1

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(2 citation statements)
references
References 68 publications
0
2
0
Order By: Relevance
“…Within an individual's lifetime, chronically antagonizing the eCB system during adolescence alters the development of adult female, but not male, rat social investigation. This effect correlates with altered neural activity in the NAc and prefrontal cortex, and points to a role for this system in shaping normal, species-specific social interactions [80].…”
Section: Endocannabinoid Interactions With the Oxytocin System Modula...mentioning
confidence: 84%
See 1 more Smart Citation
“…Within an individual's lifetime, chronically antagonizing the eCB system during adolescence alters the development of adult female, but not male, rat social investigation. This effect correlates with altered neural activity in the NAc and prefrontal cortex, and points to a role for this system in shaping normal, species-specific social interactions [80].…”
Section: Endocannabinoid Interactions With the Oxytocin System Modula...mentioning
confidence: 84%
“…Within an individual's lifetime, chronically antagonizing the eCB system during adolescence alters the development of adult female, but not male, rat social investigation. This effect correlates with altered neural activity in the NAc and prefrontal cortex, and points to a role for this system in shaping normal, species-specific social interactions [80]. Meanwhile, acutely prolonging the effects of the endogenously released CB1 receptor ligand anandamide in the NAc of adolescent male Wistar rats increases the reward of social play, though the role of anandamide in the amygdala appears to be even more critical for this [81].…”
Section: Endocannabinoid Interactions With the Oxytocin System Modula...mentioning
confidence: 99%