Background The challenges that a professional face when working in the field of psychiatry require the development of adequate defensive and coping styles. Aims To explore the coping strategies, the defense mechanisms and their relationship among psychiatry trainees in Romania. Materials and methods A cross-sectional study was conducted to determine and to evaluate both defensive and coping styles of Romanian psychiatry trainees. DSQ-60 and COPE scales were applied to psychiatry trainees from five training centers in Romania. By applying structural equation modeling, we studied models that presumed the existence of relationships between coping strategies and defensive mechanisms. Results The results of the study indicate that defense mechanisms and task-oriented coping style were the commonly used approach by trainees in psychiatry. In addition, our findings show significantly consistent correlations (ranging from 0.2 to 0.5) between adaptive defense mechanisms and coping styles focused on the problem, or on the emotion. Similarly, the avoidant coping strategies correlated with defense styles that are not adaptive (correlations between 0.3 and 0.5). Our model presented good fit indices, X2(34) = 50.519, p < 0.001; GFI = 0.93; RMSE = 0.08. Moreover, the results indicated a weak association, r = 0.01, p < 0.001, between the two types of adaptive processes. Conclusions Our findings suggest that trainees in psychiatry present aprofile based on two independent groups of adaptation processes, namely, adaptive defenses and problem-oriented coping scales, and non-adaptive defenses and avoidant coping scales.