Virologic response to highly active antiretroviral therapy (HAART) treatment of human immunodeficiency virus (HIV) infection depends on viral sensitivity to antiretrovirals (ARV's) and excellent medication adherence. Adolescents with vertically-acquired HIV may require complicated regimens due to significant treatment experience and often have poor medication adherence. A retrospective chart review identified five adolescents with vertically acquired HIV and plasma HIV viral load rebound or nonresponse on a stable HAART regimen followed by a period of directly observed therapy (DOT) in a clinic or hospital setting with serial viral load measurements. Four subjects had a virologic response (mean decline 1.15 log) after DOT. A response to HAART can be seen despite ARV resistance using DOT, and treatment-experienced patients seemingly unresponsive to HAART may be non-adherent even with reassuring adherence measures. A period of clinicmonitored DOT may allow diagnosis of non-adherence, discussion of medication barriers and avoidance of unnecessary medication changes.
KeywordsHIV/AIDS; Directly Observed Therapy; adolescence; adherence; virologic response Highly active antiretroviral therapy (HAART) is remarkably effective in suppressing HIV replication, preventing opportunistic infections, and prolonging life in children and adults with HIV infection (Gortmaker et al., 2001;Palella et al., 1998). However, the success of HAART Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. (Watson & Farley, 1999).
NIH Public AccessAdherence to medications is often difficult in the pediatric population for reasons generally related to the developmental stage of the patient. In younger children, poor medication tolerability and palatability, lack of available liquid formulations for some medications, and caregiver non-adherence hinder adherence.In the adolescent population, psychosocial factors contribute greatly to non-adherence to antiretrovirals (ARVs), and often adolescents are given independence in taking medications despite not fully understanding their regimens (Martin, Elliot, Toledo-Tamula, Wolters, & Wood, 2004;Murphy et al., 2003). However, data on adherence to ARVs in vertically-infected adolescents are limited. In a study by Van Dyke et al., 2002, almost one-third of 125 HIVinfected pediatric subjects, most of whom were not adolescents, reported non-adherence to ARVs over the course of one year. Only 41% of a group of 161 HIV-positive adolescents infected via sexual contact or drug injection reported full ARV adherence (Murphy et al., 2003).Although adolescents with behavi...