Adolescent Diet and Subsequent Serum Hormones, Breast Density, and Bone Mineral Density in Young Women: Results of the Dietary Intervention Study in Children Follow-up Study

Dorgan, Joanne F.; Liu, Lea; Klifa, Catherine; Hylton, Nola M.; Shepherd, John; Stanczyk, Frank Z.; Snetselaar, Linda; Horn, Linda Van; Stevens, Victor J.; Robson, Alan M.; Kwiterovich, Peter O.; Lasser, Norman L.; Himes, John H.; Gabriel, Kelley Pettee; Kriska, Andrea M.; Ruder, Elizabeth H.; Fang, Carolyn Y.; Barton, Bruce

doi:10.1158/1055-9965.epi-09-1259

Cited by 35 publications

(52 citation statements)

References 57 publications

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“…However, at the time of DISC06 visit, only 8% of the study participants had elevated LDL-C, and the prevalence of overweight in our analyses (44%) was similar to the US average for women in 20s (45.6%) (86). Although the study participants were randomized to a diet intervention or usual care control group, intervention assignment had no long-term effect on breast density (34) and did not modify associations of sex hormones with breast density measures. Although data was obtained at different sites, all our data were collected using standardized procedures to ensure data integrity.…”

Section: Discussionmentioning

confidence: 99%

“…The intervention continued until 1997, when the mean age of the participants was 16.7 years old (38). From 2006 to 2008, the DISC06 Follow-Up Study evaluated the effect of diet intervention during puberty on biomarkers associated with breast cancer risk among a subgroup of 260 DISC women aged 25–29 years (34, 35). Assents from study participants and informed consents from their parents or guardians were obtained prior to the DISC trial and informed consents from participants were obtained prior to the DISC06 Follow-Up Study.…”

Section: Methodsmentioning

confidence: 99%

“…All analyses were conducted following standard procedures at the Reproductive Endocrine Research Laboratory, University of Southern California Keck School of Medicine (34). Unconjugated estradiol (41), progesterone (42), and testosterone (43) were quantified by specific radioimmunoassays (RIAs) following extraction and Celite column partition chromatography.…”

Section: Methodsmentioning

confidence: 99%

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Endogenous Sex Hormones and Breast Density in Young Women

Jung

Stanczyk

Egleston

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Breast density is a strong risk factor for breast cancer and reflects epithelial and stromal content. Breast tissue is particularly sensitive to hormonal stimuli before it fully differentiates following the first full-term pregnancy. Few studies have examined associations between sex hormones and breast density among young women. Methods We conducted cross-sectional study among 180 women aged 25-29 years old who participated in the Dietary Intervention Study in Children 2006 Follow-up Study. Eighty-five percent of participants attended a clinic visit during their luteal phase of menstrual cycle. Magnetic resonance imaging measured the percentage of dense breast volume (%DBV), absolute dense breast volume (ADBV), and absolute nondense breast volume (ANDBV). Multiple-linear mixed-effect regression models were used to evaluate the association of sex hormones and sex hormone-binding globulin (SHBG) with %DBV, ADBV, and ANDBV. Results Testosterone was significantly positively associated with %DBV and ADBV. The multivariable geometric mean of %DBV and ADBV across testosterone quartiles increased from 16.5% to 20.3% and from 68.6cm3 to 82.3cm3, respectively (Ptrend ≤ 0.03). There was no association of %DBV or ADBV with estrogens, progesterone, non-SHBG bound testosterone or SHBG (Ptrend ≥ 0.27). Neither sex hormones nor SHBG was associated with ANDBV except progesterone; however, the progesterone result was nonsignificant in analysis restricted to women in the luteal phase. Conclusions These findings suggest a modest positive association between testosterone and breast density in young women. Impact Hormonal influences at critical periods may contribute to morphological differences in the breast associated with breast cancer risk later in life.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Endogenous Sex Hormones and Breast Density in Young Women

Jung

Stanczyk

Egleston

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…In a dietary intervention study, preadolescent girls (ages 8–10) were randomly assigned to usual care or to an intervention group with a low-fat and high-fiber diet and showed lower serum estradiol and progesterone levels in the intervention group during adolescence [33]. However, such differences did not persist during the transition of adolescence to young adulthood [34]. An inverse association between fiber intake and breast cancer risk may operate through modulating the insulin-like growth factor (IGF) system.…”

Section: Discussionmentioning

confidence: 99%

Adolescent dietary fiber, vegetable fat, vegetable protein, and nut intakes and breast cancer risk

Liu

Colditz

Cotterchio

et al. 2014

Breast Cancer Res Treat

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Purpose The importance of early-life exposures in breast cancer development is increasingly recognized. However, limited research has evaluated the relationship between adolescent diet and subsequent risk of breast cancer and reported inconsistent results. This population-based case-control study investigated the associations of dietary fiber, vegetable protein, vegetable fat, and nuts consumed during adolescence with adult breast cancer risk. Methods Women, ages 25–74 years, who were diagnosed with first primary breast cancer between 2002 and 2003 were identified using the Ontario Cancer Registry. Controls were identified through random digit dialing and age-frequency matched to cases. Diet at ages 10–15 was assessed with a 55-item food frequency questionnaire among 2,865 cases and 3,299 controls. Logistic regression was performed to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results Inverse associations were found between intakes of dietary fiber, vegetable protein, vegetable fat, and nuts during adolescence and breast cancer risk, which persisted after controlling for adult intakes. The ORs (95% CI) for the highest versus the lowest quintile of intake were 0.66 (0.55 to 0.78; Ptrend<0.0001) for fiber, 0.80 (0.68 to 0.95; Ptrend=0.01) for vegetable protein, 0.74 (0.63 to 0.87; Ptrend=0.002) for vegetable fat, 0.76 (0.61 to 0.95 for ≥1 serving/day versus <1 serving/month intake; Ptrend=0.04) for nuts. The reduced risk for adolescent intakes of fiber, vegetable protein and nuts was largely limited to postmenopausal women (Pinteraction≤0.05). Conclusions Dietary fiber, vegetable protein, vegetable fat, and nuts consumed during adolescence were associated with reduced breast cancer risk.

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“…No association was found between childhood or adolescent diet and BD in adulthood. 27,64,68,[93][94][95] Overall PMD reduction…”

Section: Resultsmentioning

confidence: 99%

Relationship Between Breast Density and Selective Estrogen-Receptor Modulators, Aromatase Inhibitors, Physical Activity, and Diet

et al. 2016

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Background. Lower breast density (BD) is associated with lower risk of breast cancer and may serve as a biomarker for the efficacy of chemopreventive strategies. This review explores parameters that are thought to be associated with lower BD. We conducted a systematic review of articles published to date using the PRISMA strategy. Articles that assessed change in BD with estrogen-receptor modulators (tamoxifene [TAM], raloxifene [RLX], and tibolone) and aromatase inhibitors (AIs), as well as cross-sectional and longitudinal studies (LSs) that assessed association between BD and physical activity (PA) or diet were reviewed. Results. Ten studies assessed change in BD with TAM; all reported TAM-mediated BD decreases. Change in BD with RLX was assessed by 11 studies; 3 reported a reduction in BD. Effect of tibolone was assessed by 5 RCTs; only 1 reported change in BD. AI-mediated BD reduction was reported by 3 out of 10 studies. The association between PA and BD was assessed by 21 studies; 4 reported an inverse association. The relationship between diet and BD was assessed in 34 studies. All studies on calcium and vitamin D as well as vegetable intake reported an inverse association with BD in premenopausal women. Two RCTs demonstrated BD reduction with a low-fat, high-carbohydrate intervention. Conclusion. TAM induces BD reduction; however, the effect of RLX, tibolone, and AIs on BD is unclear. Although data on association between diet and BD in adulthood are contradictory, intake of vegetables, vitamin D, and calcium appear to be associated with lower BD in premenopausal women.

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Adolescent Diet and Subsequent Serum Hormones, Breast Density, and Bone Mineral Density in Young Women: Results of the Dietary Intervention Study in Children Follow-up Study

Cited by 35 publications

References 57 publications

Endogenous Sex Hormones and Breast Density in Young Women

Endogenous Sex Hormones and Breast Density in Young Women

Adolescent dietary fiber, vegetable fat, vegetable protein, and nut intakes and breast cancer risk

Relationship Between Breast Density and Selective Estrogen-Receptor Modulators, Aromatase Inhibitors, Physical Activity, and Diet

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