Adolescent Girl with Down Syndrome and Lumbar Cutaneous Melanoma

Satgé, Daniel; Dimoux-Dime, Guy; Godard, W; Fréminville, Bénédicte de

doi:10.1111/j.1525-1470.2012.01764.x

Cited by 7 publications

(8 citation statements)

References 8 publications

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“…Cutaneous malignancies, including melanoma and non‐melanoma skin cancer, have been infrequently reported in DS and affected only 2 of our patients, both middle‐aged Caucasians 38‐41 . As life expectancy in DS increases, annual skin examinations should be encouraged.…”

Section: Discussionmentioning

confidence: 91%

Dermatologic conditions in Down syndrome: A single‐center retrospective chart review

Rork

McCormack

Lal

et al. 2020

Pediatric Dermatology

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Background: Current literature addressing dermatologic conditions associated with Down syndrome is limited, with emphasis on rare skin conditions and lack of consensus on the incidence of more common disorders. Objective: We sought to evaluate dermatologic conditions in patients with Down syndrome diagnosed and managed by dermatologists. Methods: This was a retrospective analysis of 101 pediatric and adult patients with Down syndrome seen by the University of Massachusetts Dermatology Department between 2008 and 2018. Results: Folliculitis was the most common diagnosis overall (30.7%), followed by seborrheic dermatitis (26.7%) and hidradenitis suppurativa (22.8%). Eczematous dermatitis, alopecia areata, and xerosis were the most common diagnoses observed in children aged 0-12 years; hidradenitis suppurativa, folliculitis, and seborrheic dermatitis in adolescents aged 13-17 years; and folliculitis, seborrheic dermatitis, and xerosis in adults 18 years and older. Other notable diagnoses present overall included onychomycosis (9.9%) and psoriasis (8.9%). Malignant cutaneous tumors were present in two patients, specifically basal cell carcinoma and malignant melanoma in situ. Limitations: This was a retrospective, single-institution study. Conclusion: Dermatologic conditions in patients with Down syndrome vary by age but are most often adnexal and eczematous disorders. Trisomy of chromosome 21 and the resulting downstream effects, specifically on the immune system, may account for these findings.

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Section: Discussionmentioning

confidence: 91%

Dermatologic conditions in Down syndrome: A single‐center retrospective chart review

Rork

McCormack

Lal

et al. 2020

Pediatric Dermatology

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“…Little data have been published about the association between melanoma and ID. However, individuals with Down syndrome are suspected to have a lower melanoma incidence than in the general population (Satgé et al 2014a). This could be explained by reduced occupational and recreational UV exposure but also by genetic factors.…”

Section: Discussionmentioning

confidence: 99%

“…While overall cancer incidence within the ID population is similar to that of the general population (Sullivan et al 2004), some cancers are more frequent in people with ID, including leukaemia, sarcoma, cancers of the digestive system (especially gallbladder, stomach and liver), thyroid gland, testes and central nervous system (Patja et al 2001;Sullivan et al 2004;Satgé and Seidel 2018). Few case reports have described melanoma in the ID population (Parry et al 1986;Nakano et al 1993;Petty et al 1993;Evenhuis et al 1996;Kwok-Oleksy et al 2012;Satgé et al 2014a;Lesage et al 2017). Two epidemiological studies on cancer incidence evaluated the standardised incidence ratio of melanoma in this population at 0.6 in Finland and at 0.58 for men and 0.88 for women, in Western Australia, suggesting that this incidence is nearly two third that of the general population (Patja et al 2001;Sullivan et al 2004), but still, prognostic factors at diagnosis in this population remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Melanoma and intellectual disability: do prognostic factors at diagnosis differ from general population?

Lesage

Habib-Hadef²,

Trétarre

et al. 2022

J intellect Disabil Res

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Background Few melanoma cases are reported in individuals with intellectual disability (ID), and prognostic factors at diagnosis are unknown in this population. This work was designed to investigate whether prognostic factors at diagnostic are different in patients with ID compared with a general population. Methods Melanoma cases retrieved from Hérault's Tumour Registry (HTR) from 1995 to 2015 were cross-referenced against a list of adult patients with ID, living in Hérault. Major prognostic factors were compared with those in non-ID melanoma patients included in HTR and in patients followed by Montpellier University Hospital and included in the Réseau pour la Recherche et l'Investigation Clinique sur le Mélanome (RIC-Mel) database. ResultsTen melanoma cases in individuals with ID were identified and compared with 3804 non-ID melanoma cases in HTR and 1024 non-ID melanoma cases included in RIC-Mel. Mean Breslow thickness at diagnosis was 4.6 mm in melanoma cases among those with ID versus 1.89 mm in HTR (P = 0.109) and 2.36 mm in RIC-Mel (P = 0.156). Stage at diagnosis was superior to stage IIB in 42.9% of ID cases versus 11.4% of non-ID cases in HTR (P < 0.05) and 8.5% in RIC-Mel (P < 0.05). Conclusions Melanomas in patients with ID had less favourable prognostic factors at diagnosis, including higher Breslow thickness and more advanced stage, than melanomas in non-ID patients. These adverse prognostic factors indicate a later diagnosis in this population, leading to a poorer prognosis. This work underlines the need to improve melanoma screening among individuals with ID.

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“…Three patients with cutaneous melanomas were reported (Multimedia Appendix 10) [111][112][113]. Jafarian et al [111] reported an 11-year-old patient with a stage IIA melanoma of the leg.…”

Section: Melanomamentioning

confidence: 99%

Common Dermatologic Disorders in Down Syndrome: Systematic Review

Lam¹,

Lu²,

Elhadad³

et al. 2022

JMIR Dermatol

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Background Down syndrome (DS) has been associated with cardiovascular, gastrointestinal, and immune-related abnormalities. Several dermatologic conditions, including hidradenitis suppurativa, have also been found to be associated with DS. Objective The objective of this study was to characterize the prevalence, presentation, and unique features of dermatologic disorders associated with DS. Methods Electronic searches of EMBASE (via Ovid), MEDLINE (via Ovid), and Web of Science databases were conducted on December 14, 2020. Observational studies including case reports of patients with DS presenting with concomitant primary dermatologic disorder were included. Results This systematic review captured 40 observational studies and 99 case reports, including 10 observational studies that examined the prevalence of common skin disorders in patients with DS. The most common dermatologic conditions reported includes atopic dermatitis (8 studies, n=180; 19.7% mean prevalence), hidradenitis suppurativa (15, n=478; 3.2%), ichthyosis (4, n=16; 4.7%), lichen nitidus (6, n=6; 1.1%), psoriasis (21, n=65; 4.8%), alopecia areata (27, n=253; 7.4%), vitiligo (8, n=40; 4.4%), onychomycosis (3, n=198; 24.7%), calcinosis cutis (14, n=15), connective tissue nevi (6, n=6), dermatofibroma (3, n=3), melanoma (3, n=3), syringomas (14, n=182; 21.2%), and elastosis perforans serpiginosa (19, n=24; 0.5%). Conclusions Our results indicate an increased prevalence of common cutaneous disorders in patients with DS, particularly infectious, inflammatory, autoimmune, and connective tissue conditions. Current guidelines for the screening, general management, and use of systemic immunomodulatory agents in this patient population are lacking. Patients with DS would benefit from screening for dermatologic disorders not otherwise regularly performed for earlier diagnosis and treatment. Trial Registration PROSPERO International Prospective Register of Systematic Reviews CRD42021226295; https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=226295

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Adolescent Girl with Down Syndrome and Lumbar Cutaneous Melanoma

Abstract: Melanoma has rarely been reported in people with Down syndrome, and its frequency in this condition has not been clearly established. We report a 19-year-old woman with Down syndrome and lumbar melanoma. This possible association must be kept in mind.

Cited by 7 publications

References 8 publications

Dermatologic conditions in Down syndrome: A single‐center retrospective chart review

Dermatologic conditions in Down syndrome: A single‐center retrospective chart review

Melanoma and intellectual disability: do prognostic factors at diagnosis differ from general population?

Common Dermatologic Disorders in Down Syndrome: Systematic Review

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