Adolescent Health-Related Quality of Life Following Liver and Kidney Transplantation

Sundaram, Shikha S.; Landgraf, Jeanne M.; Neighbors, Katie; Cohn, Richard A.; Alonso, Estella M.

doi:10.1111/j.1600-6143.2006.01722.x

Cited by 86 publications

(107 citation statements)

References 35 publications

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“…Furthermore, a majority of studies rely on parent report rather than self-report, which has shown to be an unreliable method of assessing HRQL (12,13). The limitations of published studies notwithstanding, attempts to identify factors associated with reduced quality of life (QoL) have been described previously (9,(14)(15)(16) (17) and was based on a structured definition of HRQL specific to young people (18 (20) and has been used in previous studies of HRQL in children after LT (9)(10)(11)(14)(15)(16)21 …”

Section: Liver Transplantation (Lt) Has Become the Standard Treatmentmentioning

confidence: 99%

“…The transplant-related variables that might affect HRQL were derived from a literature review (14)(15)(16)22 (25,26). The MTSOSD has been used in adult liver, heart and renal transplant recipients (23,27,28).…”

Section: Transplant-related Variablesmentioning

confidence: 99%

“…Young people after LT had comparable total scores to the general population for self-esteem and emotional state; however, they scored significantly worst on the measure of behavior (total score). (10,16,43). Possible explanations are the use of incentive payments to participate (10) and the use of different normative reference groups.…”

Section: Family-related Variablesmentioning

confidence: 99%

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Study of the Factors Affecting Health-Related Quality of Life in Adolescents After Liver Transplantation

Taylor

Franck

Donaldson

et al. 2009

American Journal of Transplantation

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The aim of the study was to identify factors affecting health-related quality of life (HRQL) in adolescents after liver transplantation. HRQL was measured using the CHQ-CF87 in 55 adolescents, aged 12-18 years. Factors associated with HRQL included allograft morbidity, psychological and family-related variables measured through standardized questionnaires. The domains of the CHQ-CF87 were reduced using factor analysis to give physical, psychological and social domains. Impacting factors were identified through stepwise, multiple regression analysis. Adolescents had significantly lower HRQL in every domain except for role/social-behavior and family cohesion compared to the general population. Adolescents experienced median 18 (range 4-31) symptoms related to immunosuppression, 40(75%) had one or more chronic illnesses related to immunosuppression and 12(22%) had a history of emotional difficulties. Self-esteem and emotional health were similar to the general population but behavior and aspects of family function were lower. Following regression analysis, the factors associated with HRQL were: age at transplant, secondary chronic illness, symptom distress, headaches, history of emotional difficulties, self-esteem and family conflict. These explained 57% of the variance in physical function, 61% of psychological function and 39% of social function. HRQL is significantly reduced in adolescents after transplantation, which could be related to immunosuppression and psychosocial factors.

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Section: Liver Transplantation (Lt) Has Become the Standard Treatmentmentioning

confidence: 99%

Section: Transplant-related Variablesmentioning

confidence: 99%

Section: Family-related Variablesmentioning

confidence: 99%

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Study of the Factors Affecting Health-Related Quality of Life in Adolescents After Liver Transplantation

Taylor

Franck

Donaldson

et al. 2009

American Journal of Transplantation

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“…Most of these pediatric studies were conducted among heterogeneous samples with respect to age and the period since LT, and psychological and social development has often been assessed by parental reports (8)(9)(10)(11)21). In a recent study including self-assessment of QOL, 11-to 18 year-old adolescent liver transplant recipients reported physical and psychosocial function very similar to that of a healthy middle school population, despite poorer general health (22). No study has specifically focused on assessing the psychosocial adjustment of young adults who experienced LT in early life.…”

Section: Introductionmentioning

confidence: 99%

Current Lifestyle of Young Adults After Liver Transplantation During Childhood

Dommergues

Letierce

Gravereau

et al. 2010

American Journal of Transplantation

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The authors studied the psychosocial adjustment of pediatric liver transplant (LT) recipients reaching adulthood. The study comprised phone interviews of 116 volunteers aged 17-33 years. Results were compared to those for healthy peers and 65 patients who were eligible for inclusion but did not participate. Participants' median age at LT was 6 years and the median period since LT was 15 years. Of the 116 participants, 76% considered their quality of life as good or very good. Seventy-five patients (65%) were attending schools, 27 of whom were 2 years or more below the age-appropriate level. Of the remaining 41 patients, 26 had a job and 15 were unemployed. Poor compliance with medications was reported by 52 patients (45%). Alcohol consumption was lower than in the reference population (p < 0.001). Anxiety, loneliness and negative thoughts were expressed by 53, 84 and 47% of the participants, respectively. Thirteen patients (11%) were being cared for by psychologists or psychiatrists. The 65 nonparticipants had greater psychological problems than the participants, and a lower educational level. In conclusion, after LT in early life, most patients displayed psychological vulnerability during early adulthood. The educational level of patients was lower than that of theirs peers.

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“…Renal transplantasyon, son dönem böbrek yetmezliği olan hastalarda hayat kurtaran bir tedavi yöntemi olması yanında, hastanın yaşam kalitesine de önemli katkı sağlamak-tadır 1 . Son yıllarda, cerrahi işlemlerdeki ilerlemelerin yanında, immün süpresif tedavilerdeki gelişmelerle birlikte, immünolojik hasar önlenebilmekte, akut ve kronik böbrek kayıplarının önüne geçilebilmektedir 2 .…”

Section: Introductionunclassified

BK Virus Infections in Pediatric Kidney Transplant Recipients

Mutlu¹,

Sağlık²,

Koyun³

et al. 2013

Mikrobiyol Bul

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* Bu çalışmada kullanılan hasta verilerinin bir kısmı, 4. Ulusal Viroloji Kongresi (23-26 Haziran 2011, İstanbul)'nde sunulmuştur. ÖZETPrimer BK virus (BKV) enfeksiyonları genellikle erken çocukluk döneminde kazanılmakta ve asemptomatik olarak geçirilmektedir. Dünyadaki erişkin popülasyonlarda BKV seroprevalansı %90'a kadar ulaşa-bilir. Primer enfeksiyondan sonra virus ürogenital sistemde latent olarak kalmaktadır. Renal transplant alı-cılarında, BKV'nin neden olduğu primer enfeksiyonlar ve reaktivasyonlar, hastaların %10'unu etkileyebilmekte ve önlem alınmadığı taktirde bu hastaların yarısından fazlası BKV nefropatisi (BKVN) nedeniyle böbreklerini kaybetmektedir. BKVN'ye bağlı greft kaybını engellemenin tek yolu, transplantasyon sonrasında BK virus enfeksiyonlarının takibi ve BKVN geliştiren hastaların erken dönemde tanınıp etkin bir biçimde tedavi edilmeleridir. Bu çalışmada, pediatrik renal transplant alıcılarında, transplantasyon sonrası dönemde, idrar ve plazma örneklerinden, gerçek zamanlı polimeraz zincir reaksiyonu (rtPCR) ile BKV enGeliş Tarihi

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Adolescent Health-Related Quality of Life Following Liver and Kidney Transplantation

Cited by 86 publications

References 35 publications

Study of the Factors Affecting Health-Related Quality of Life in Adolescents After Liver Transplantation

Study of the Factors Affecting Health-Related Quality of Life in Adolescents After Liver Transplantation

Current Lifestyle of Young Adults After Liver Transplantation During Childhood

BK Virus Infections in Pediatric Kidney Transplant Recipients

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