Adolescent Idiopathic Scoliosis

Choudhry, Muhammad; Ahmad, Zuber; Verma, Rajat

doi:10.2174/1874325001610010143

Cited by 160 publications

(143 citation statements)

References 31 publications

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“…Surgery not only changes the shape of the spine but also the shape of the torso [21]. One of the aims of a surgical procedure is to minimise any asymmetries in the torso and spine [17]. It is of interest to see that the results of this paper show that surgery increases the difference in the y-axis but decreases the difference in the z-axis of the most prominent points between the left and right sides of the torso.…”

Section: Discussionmentioning

confidence: 89%

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A Description of Three-Dimensional Shape of the Posterior Torso Comparing Those with and without Scoliosis

2019

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Scoliosis results in a 3D asymmetry of the spine and torso. It is not clear what the variability in 3D shape is in a non-scoliotic population, how much that is altered by scoliosis and what surgery does to that. This study is a 3D analysis of the shape of the torso in a cohort of non-scoliotic children that is then compared with a cohort of those with scoliosis both pre- and post-operatively. Procrustes analysis is used to examine the mean 3D shape. There is variability in shape in the non-scoliotic cohort. Scoliosis increases this asymmetry, particularly around the most prominent areas of the torso. Surgery alters the torso asymmetry but increases the difference in height between the right and the left with regard to the most prominent points on the torso. There is a degree of asymmetry seen in a non-scoliotic cohort of children. Scoliosis increases that asymmetry. Surgery alters the asymmetry but causes an increase in some of the 3D elements of the most prominent areas of the torso.

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Section: Discussionmentioning

confidence: 89%

“…Scoliosis is a disorder of the shape of the spine and torso [17]. The visual appearance of the torso to the patient and family is often the trigger for a referral for a specialist opinion [17]. Patients and surgeons are concerned about the spine and the asymmetry of the torso [2,3,18].…”

Section: Discussionmentioning

confidence: 99%

A Description of Three-Dimensional Shape of the Posterior Torso Comparing Those with and without Scoliosis

2019

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“…Adolescent idiopathic scoliosis (AIS) is a common disease with an overall prevalence of 0.47–5.2% . It is the most common spinal pathology occurring in children and attended to by orthopedic surgeons . AIS is a tridimensional spine deformity with a lateral curvature greater than 10 degrees with vertebrae rotation and sagittal plane imbalance .…”

mentioning

confidence: 99%

“…1 It is the most common spinal pathology occurring in children and attended to by orthopedic surgeons. 2,3 AIS is a tridimensional spine deformity with a lateral curvature greater than 10 degrees with vertebrae rotation and sagittal plane imbalance. [3][4][5] Progression of the deformity occurs in 10-15% of cases and is most common in females during pubertal growth.…”

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confidence: 99%

TIMP2 Polymorphisms Association With Curve Initiation and Progression of Thoracic Idiopathic Scoliosis in the Caucasian Females

Andrusiewicz

Harasymczuk

Janusz

et al. 2019

Journal Orthopaedic Research

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Idiopathic scoliosis (IS) etiology remains unclear, but strong genetic background is suggested. Previously reported TIMP2 study indicates an association of genic rs8179090 with IS progression in a Han Chinese population. However, there has been a lack of investigation into intragenic TIMP2 polymorphisms in IS patients. We recruited 100 Caucasian females with IS and 100 controls. Patients were subdivided accordingly to: progression rate, curve severity, joint mobility, and curve pattern. Allele‐specific‐polymerase chain reaction based on fluorescence resonance energy transfer was applied to evaluate nine TIMP2 polymorphisms. Distribution of genotype and allele frequency in only one polymorphism (rs11658743) differed in case–control study. Four of the polymorphisms (rs2277700, rs11077401, rs2376999, and rs4789934) showed non‐equal distributions either in genotype or/and allele distributions in the patients of different progression rates. The rs11077401 was related to curve severity patients distinction and the rs8179090 distinguished patients with different joint mobility level. Two polymorphisms either differed statistically in case of curve patterns subgrouping (rs8068674 and rs8179090) or showed a slight tendency toward significance in the recessive model of allele distributions (rs9916809 and rs8179090). The remaining two polymorphisms (rs2377005, rs11658743) showed no association with either clinical or radiographic IS characteristics. The influence of the G allele of the rs8179090 on the clinical course of IS has not yet been confirmed. We identified four TIMP2 polymorphisms (rs11077401, rs2376999, rs2277700, and rs4789934) that were associated with a higher risk of the progressive IS form. Further genetic association studies based on suggested clinical criteria would be necessary to validate TIMP2 polymorphisms associated with the curve progression. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2217–2225, 2019

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“…Scoliosis is a common orthopaedic condition in children and adolescents 1 . It is a complex three-dimensional deformity of the spine, featuring lateral spinal curvature and a rotational deformity of the vertebrae and ribs.…”

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confidence: 99%

The Schroth method of physical therapy for the treatment of idiopathic scoliosis

Stergiou¹

2018

JRPMS

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Adolescent Idiopathic Scoliosis

Cited by 160 publications

References 31 publications

A Description of Three-Dimensional Shape of the Posterior Torso Comparing Those with and without Scoliosis

A Description of Three-Dimensional Shape of the Posterior Torso Comparing Those with and without Scoliosis

TIMP2 Polymorphisms Association With Curve Initiation and Progression of Thoracic Idiopathic Scoliosis in the Caucasian Females

The Schroth method of physical therapy for the treatment of idiopathic scoliosis

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