Adolescent idiopathic scoliosis

Altaf, Farhaan; Gibson, Alexander; Dannawi, Zaher; Noordeen, Hilali

doi:10.1136/bmj.f2508

Cited by 244 publications

(222 citation statements)

References 28 publications

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“…This spinal deformation occurs mostly among pubescent girls [4]. Many authors emphasize multifactorial pathomechanism of scoliosis [5][6][7][8], and the involvement of genetic and epigenetic predispositions, and the influence of hormonal factors are widely accepted [6,7,[9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Participation of sex hormones in multifactorial pathogenesis of adolescent idiopathic scoliosis

Kulis

Goździalska

Drąg

et al. 2015

International Orthopaedics (SICOT)

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Purpose In order to verify the potential association between the aetiopathogenesis of adolescent idiopathic scoliosis (AIS) and the process of sexual maturation, we determined the concentrations of oestrogens in pre-and postmenarcheal girls affected by this condition. AIS, occurring mostly in pubescent girls, is one of the most frequent forms of faulty posture. Therefore, it was assumed that the multifactorial pathomechanism of AIS involves significant deficiency of oestrogens. Methods The diagnosis of AIS was established on the basis of physical examination and analyses of radiograms. Concentrations of FSH, LH, oestrogens, progesterone, osteocalcin and RANKL were determined by ELISA. The activity of alkaline phosphatase (AP) was measured by kinetic method. The study included pre-and postmenarcheal girls with AIS and corresponding groups of scoliosis-free controls. Results In premenarcheal scoliotic girls, the levels of FSH, LH and oestradiol were lower; the levels of progesterone, oestrone and oestriol were higher; and the concentrations of oestrone and oestriol were similar compared to premenarcheal controls. Higher levels of RANKL, osteocalcin and AP were observed in premenarcheal adolescents with AIS compared to controls. The concentrations of FSH, LH, oestradiol, and progesterone in postmenarcheal girls with scoliosis were lower, oestrone were slightly lower and oestriol did not differ compared with the control group. Significantly higher levels of RANKL, osteoc alcin an d A P w ere o bserv ed i n postmenarcheal scoliotic adolescents compared with controls. Conclusions There is an interdependence between the concentration of oestradiol and development of scoliosis. Determination of estradiol may have diagnostic value in the screening of spinal pathologies associated with AIS.

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Section: Introductionmentioning

confidence: 99%

Participation of sex hormones in multifactorial pathogenesis of adolescent idiopathic scoliosis

Kulis

Goździalska

Drąg

et al. 2015

International Orthopaedics (SICOT)

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“…The coincidence, however, of appearance of idiopathic scoliosis (1:25-50) and situs inversus (1:8000-25,000) in one patient simultaneously is 1:200,000-1,250,000, making such a study almost impossible to carry out [9][10][11]. We sent an informal written inquiry via the newsletter of the Scoliosis Research Society to a large worldwide group of scoliosis surgeons in 2011 and could not identify any cases with this rare combination.…”

Section: Discussionmentioning

confidence: 99%

“…The chance of occurrence of idiopathic scoliosis (1:25-50) and situs inversus totalis (1:8000-25,000) in one patient, simultaneously, however, is 1:200,000-1,250,000, making this combination difficult to study in the general population [9][10][11]. Primary ciliary dyskinesia (PCD) is a disease that is caused by defects in the motile cilia.…”

Section: Introductionmentioning

confidence: 99%

Scoliosis convexity and organ anatomy are related

et al. 2017

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Purpose Primary ciliary dyskinesia (PCD) is a respiratory syndrome in which 'random' organ orientation can occur; with approximately 46% of patients developing situs inversus totalis at organogenesis. The aim of this study was to explore the relationship between organ anatomy and curve convexity by studying the prevalence and convexity of idiopathic scoliosis in PCD patients with and without situs inversus.Methods Chest radiographs of PCD patients were systematically screened for existence of significant lateral spinal deviation using the Cobb angle. Positive values represented right-sided convexity. Curve convexity and Cobb angles were compared between PCD patients with situs inversus and normal anatomy. Results A total of 198 PCD patients were screened. The prevalence of scoliosis (Cobb [10°) and significant spinal asymmetry (Cobb 5-10°) was 8 and 23%, respectively. Curve convexity and Cobb angle were significantly different within both groups between situs inversus patients and patients with normal anatomy (P B 0.009). Moreover, curve convexity correlated significantly with organ orientation (P \ 0.001; / = 0.882): In 16 PCD patients with scoliosis (8 situs inversus and 8 normal anatomy), except for one case, matching of curve convexity and orientation of organ anatomy was observed: convexity of the curve was opposite to organ orientation. Conclusions This study supports our hypothesis on the correlation between organ anatomy and curve convexity in scoliosis: the convexity of the thoracic curve is predominantly to the right in PCD patients that were 'randomized' to normal organ anatomy and to the left in patients with situs inversus totalis.

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“…En pacientes con estatura menor de 1,60 m, podría reemplazarse por radiografía convencional de columna en chasis de 35 x 43 cm. 10 …”

Section: Figura 3 Escoliómetrounclassified

“…8 Los determinantes de progresión son la edad y el sexo del paciente, la etapa de desarrollo puberal, el crecimiento potencial, el patrón y el grado de curvatura al momento del diagnóstico. 3 La combinación de estos factores puede ser útil para predecir casi el 89% de las curvas progresivas 10 (Tabla 2). El crecimiento esquelético restante puede determinarse con la velocidad de crecimiento, con la edad de la telarca y la menarca, los estadios de maduración sexual de Tanner, el signo de Risser y/o la edad ósea.…”

Section: Evolución De La Escoliosisunclassified

Consenso de escoliosis idiopática del adolescente

2016

Arch Argent Pediat

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RESUMENLa escoliosis es una condición patológica de la columna vertebral caracterizada por una deformidad espinal en las tres dimensiones del raquis (planos coronal, sagital y axial). Constituye una entidad de alta incidencia en la población pediátrica, especialmente en los adolescentes y en el sexo femenino. Se caracteriza por la presencia radiográfica de una curva en el plano frontal, cuya magnitud es mayor de 10° (técnica de Cobb). Puede ser idiopática o estar asociada a otras patologías. La escoliosis idiopática del adolescente (EIA) es aquella que se manifiesta entre los 10 años de edad y la madurez esquelética. Es más frecuente en mujeres (70%). Su diagnóstico de "idiopática" es de exclusión, ya que su presencia también puede ser originada por anomalías neuroanatómicas de la fosa cerebral posterior o del conducto raquídeo.

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Adolescent idiopathic scoliosis

Cited by 244 publications

References 28 publications

Participation of sex hormones in multifactorial pathogenesis of adolescent idiopathic scoliosis

Participation of sex hormones in multifactorial pathogenesis of adolescent idiopathic scoliosis

Scoliosis convexity and organ anatomy are related

Consenso de escoliosis idiopática del adolescente

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