2023
DOI: 10.1002/dev.22447
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Adolescent morphine exposure changes the endogenous vlPAG opioid response to inflammatory pain in rats

Kawsar Alami,
Elmira Ghasemi,
Saeed Semnanian
et al.

Abstract: Adolescence is one of the most critical periods for brain development, and exposure to morphine during this period can have long‐life effects on pain‐related behaviors. The opioid system in the periaqueductal gray (PAG) is highly vulnerable to drug exposure. However, the impact of adolescent morphine exposure (AME) on the endogenous opioid system in the PAG is currently unknown. This study aims to investigate the long‐lasting effects of AME on the endogenous opioid system and its involvement in altering nocice… Show more

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