Adolescent nicotine exposure fails to impact cocaine reward, aversion and self-administration in adult male rats

Pomfrey, Rebecca L.; Bostwick, Tamaara A.; Wetzell, Bradley; Riley, Anthony L.

doi:10.1016/j.pbb.2015.08.004

Cited by 35 publications

(29 citation statements)

References 49 publications

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“…As noted above, taste avoidance is induced by a host of other drugs (for reviews, see Gamzu et al, 1985; Hunt and Amit, 1987; Verendeev and Riley, 2011, 2012), including a variety of psychostimulants such as cocaine (Ferrari et al, 1991; Pomfrey et al, 2015), MDMA (Cobuzzi et al, 2014), amphetamine (Verendeev and Riley, 2011), caffeine (Vishwanath et al, 2011) and nicotine (Pomfrey et al, 2015; Shoaib et al, 2002). The work with cocaine is most relevant here in that its neurochemical action is similar to that of α-PVP (and MDPV) in terms of blocking the reuptake of the brain amines (see below).…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, place preference conditioning was also assessed in the present experiment. Specifically, rats were allowed access to a novel saccharin solution and injected with one of four doses of α-PVP (0, 0.3, 1.0 and 3.0 mg/kg) prior to being placed in a distinct environment, a procedure used by our laboratory (Hempel et al, 2016; King et al, 2015; Pomfrey et al, 2015; Simpson and Riley, 2005; Verendeev and Riley, 2011) and others (Brockwell et al, 1991; Sherman et al, 1980; Wang et al, 2010) to simultaneously assess the aversive (CTA) and rewarding (CPP) effects of a host of drugs of abuse.…”

Section: Introductionmentioning

confidence: 99%

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Conditioned taste avoidance, conditioned place preference and hyperthermia induced by the second generation ‘bath salt’ α-pyrrolidinopentiophenone (α-PVP)

Nelson

Hempel

Clasen

et al. 2017

Pharmacology Biochemistry and Behavior

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Background α-pyrrolidinopentiophenone (α-PVP) has been reported to be rewarding in a variety of pre-clinical models. Given that a number of drugs of abuse have both rewarding and aversive effects, the balance of which influences addiction potential, the present study examined the aversive properties of α-PVP by assessing its ability to induce taste avoidance. This assessment was made in a combined taste avoidance/place conditioning design that also allowed an evaluation of the relationship between α-PVP’s aversive and rewarding effects. Methods Male Sprague-Dawley rats were exposed to a novel saccharin solution, injected with one of four doses of α-PVP (0, 0.3, 1.0 and 3.0 mg/kg) (IP) and placed on one side of a place conditioning apparatus. The next day, they were injected with vehicle, given access to water and placed on the other side. Following four conditioning cycles, saccharin avoidance and place preferences were then assessed. The effects of α-PVP on body temperature were also examined. Results α-PVP induced dose-dependent taste avoidance as well as significant increases in time spent on the drug-paired side (although this effect was not dependent on dose). α-PVP also induced dose- and time-dependent hyperthermia. Conclusions α-PVP induced significant taste avoidance whose strength relative to the psychostimulants methylenedioxypyrovalerone (MDPV) and cocaine paralleled their relative binding to the dopamine transporter. Similar to other drugs of abuse, α-PVP has both aversive and rewarding effects. It will be important to assess how various experiential and subject variables impact these effects and their balance to predict abuse liability.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Conditioned taste avoidance, conditioned place preference and hyperthermia induced by the second generation ‘bath salt’ α-pyrrolidinopentiophenone (α-PVP)

Nelson

Hempel

Clasen

et al. 2017

Pharmacology Biochemistry and Behavior

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“…Adolescent nicotine treatment did not influence acquisition of cocaine self-administration in adult rodents (187,188), and either did not change (188) or decreased conditioned place preference (189). However, the overall cocaine intake was higher in nicotine-pretreated mice than controls (187).…”

Section: Concurrent Use Of Nicotine and Psychostimulantsmentioning

confidence: 90%

Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse

Cross

Lotfipour

Leslie

2016

The American Journal of Drug and Alcohol Abuse

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Concurrent use of tobacco and alcohol or psychostimulants represents a major public health concern, with use of one substance influencing consumption of the other. Co-abuse of these drugs leads to substantial negative health outcomes, reduced cessation, and high economic costs, but the underlying mechanisms are poorly understood. Epidemiological data suggest that tobacco use during adolescence plays a particularly significant role. Adolescence is a sensitive period of development marked by major neurobiological maturation of brain regions critical for reward processing, learning and memory, and executive function. Nicotine exposure during this time produces a unique and long-lasting vulnerability to subsequent substance use, likely via actions at cholinergic, dopaminergic, and serotonergic systems. In this review, we discuss recent clinical and preclinical data examining the genetic factors and mechanisms underlying co-use of nicotine and alcohol or cocaine and amphetamines. We evaluate the critical role of nicotinic acetylcholine receptors throughout, and emphasize the dearth of preclinical studies assessing concurrent drug exposure. We stress important age and sex differences in drug responses, and highlight a brief, low-dose nicotine exposure paradigm that may better model early use of tobacco products. The escalating use of e-cigarettes among youth necessitates a closer look at the consequences of early adolescent nicotine exposure on subsequent alcohol and drug abuse.

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“…Specifically, rats’ self-administration of stimulants in a context previously associated with nicotine resulted in enhanced intake of cocaine 18 , amphetamine 21 and nicotine 23 . However, nicotine exposure in the home cage did not always affect drug consumption 22–24 . These findings raise the possibility that nicotine-paired contextual cues, rather than the dynamic pharmacological effects of nicotine itself, enhance subsequent drug self-administration.…”

Section: Introductionmentioning

confidence: 91%

“…However, when animals are first pre-exposed to nicotine, and are then subjected to drug self-administration, results are mixed 21, 23, 24 .…”

Section: Introductionmentioning

confidence: 99%

Re-exposure to nicotine-associated context from adolescence enhances alcohol intake in adulthood

Zipori

Sadot-Sogrin

Goltseker

et al. 2017

Sci Rep

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Alcohol and nicotine are the two most commonly-abused substances and are often used together. Nicotine enhances alcohol-drinking behaviors in humans and in animals, and was suggested to enhance the reinforcing properties of other reinforcers. Here, we show that nicotine-associated environment, rather than nicotine itself, enhances alcohol intake in rats. Adolescent rats received repeated intermittent injections of nicotine (0.4 mg/kg, i.p., 5 injections, every 3rd day) or saline. The injection was paired with their home cage, or with the subsequent alcohol self-administration context. Rats were then trained to self-administer 20% alcohol. Nicotine given in the home cage did not alter subsequent alcohol intake. However, pairing nicotine with the operant chamber during adolescence led to a long-lasting increased alcohol self-administration in adulthood, compared to nicotine pre-treatment in other contexts. This effect persisted 3 months after nicotine cessation, in a relapse test after abstinence. Furthermore, re-exposure to the nicotine-associated context in adult rats led to a decrease in glial cell line-derived neurotrophic factor (Gdnf) mRNA expression in the ventral tegmental area, an effect that leads to increased alcohol consumption, as we have previously reported. Our findings suggest that retrieval of nicotine-associated contextual memories from adolescence may gate alcohol intake in adulthood, with a possible involvement of GDNF.

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Adolescent nicotine exposure fails to impact cocaine reward, aversion and self-administration in adult male rats

Cited by 35 publications

References 49 publications

Conditioned taste avoidance, conditioned place preference and hyperthermia induced by the second generation ‘bath salt’ α-pyrrolidinopentiophenone (α-PVP)

Conditioned taste avoidance, conditioned place preference and hyperthermia induced by the second generation ‘bath salt’ α-pyrrolidinopentiophenone (α-PVP)

Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse

Re-exposure to nicotine-associated context from adolescence enhances alcohol intake in adulthood

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