Adolescent Obesity and Early-Onset Type 2 Diabetes

Twig, Gilad; Zucker, Inbar; Afek, Arnon; Cukierman-Yaffe, Tali; Bendor, Cole D.; Derazne, Estela; Lutski, Miri; Shohat, Tami; Mosenzon, Ofri; Tzur, Dorit; Pinhas‐Hamiel, Orit; Tiosano, Shmuel; Raz, Itamar; Gerstein, Hertzel C.; Tirosh, Amir

doi:10.2337/dc19-1988

Cited by 115 publications

(80 citation statements)

References 46 publications

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“…These findings have implications for programs that promote interventions at various levels among children and adolescents, including in specific neighborhoods, and pertaining to food policy, education, school‐based initiatives, and environmental influences. The importance of these early intervention is emphasized by recent observation form this cohort showing a substantial increased risk for type 2 diabetes before age 25 years 42 …”

Section: Discussionmentioning

confidence: 97%

Socioeconomic inequalities and severe obesity—Sex differences in a nationwide study of 1.12 million Israeli adolescents

et al. 2020

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Summary Introduction In a nationwide population of adolescents, we investigated the sex‐specific association of socioeconomic position (SEP) with severe obesity, and trends over time. Methods The cohort comprises all Israeli adolescents (mean ± SD age 17.3 ± 0.5 years) who were medically examined, before mandatory military service during 2000 to 2015. Of 1 120 362 adolescents, 239 816 (21.4%) were classified with overweight or with obesity classes I to III using the International Obesity Task Force criteria. Data were compared between 2000 to 2009 and 2010 to 2015. Results Considering more advantaged residential SEP as the reference group, the respective odds ratios (ORs ± 95%CI) of less advantaged SEP for obesity classes I to III in 2010 to 2015 were 1.48 (1.40‐1.56), 1.66 (1.51‐1.83), and 1.73 (1.45‐2.08) for males; and 1.72 (1.60‐1.84), 1.89 (1.66‐2.15), and 2.62 (2.04‐3.37) for females. All point estimates were higher than in the preceding decade. Considering female inductees from the more advantaged SEP as the reference group, ORs were higher for males in the more advantaged SEP group, for overweight, 1.31 (1.27‐1.36); class I obesity, 1.29 (1.20‐1.38); class II obesity, 1.34 (1.18‐1.53); and class III obesity, 1.60 (1.24‐2.07). Similarly, in the less and medium advantaged SEP groups, increased ORs for males compared with females were observed in all obesity groups. Results persisted using United States Centers for Disease Control and Prevention growth charts. Conclusions Adolescents with less rather than more advantaged residential SEP are at greater risk of severe obesity. Adolescent males, of all residential SEP groups had higher odds than females for all classes of obesity.

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Section: Discussionmentioning

confidence: 97%

Socioeconomic inequalities and severe obesity—Sex differences in a nationwide study of 1.12 million Israeli adolescents

et al. 2020

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“…Individuals who were reported to the INDR as having type 2 diabetes, but without a formal date of diagnosis were considered missing in the time-to-event analysis if they were first reported in the first year of the registry, 2012; and were included only in logistic regression models. For individuals without a formal date, who were first reported in 2013 or later, we assigned the date of diagnosis as July 1 st of the year before the report year to the INDR, as described previously [14].…”

Section: The Israel National Diabetes Registry (Indr) and Diagnosis Omentioning

confidence: 99%

Adolescent BMI and early-onset type 2 diabetes among Ethiopian immigrants and their descendants: a nationwide study

Simchoni

Hamiel

Pinhas‐Hamiel

et al. 2020

Cardiovasc Diabetol

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Background We assessed in a nationwide cohort the association between adolescent BMI and early-onset (< 40 years) type 2 diabetes among Israelis of Ethiopian origin. Methods Normoglycemic adolescents (range 16–20 years old), including 93,806 native Israelis (≥ 3rd generation in Israel) and 27,684 Israelis of Ethiopian origin, were medically assessed for military service between 1996 and 2011. Weight and height were measured. Data were linked to the Israeli National Diabetes Registry. Incident type 2 diabetes by December 31, 2016 was the outcome. Cox regression models stratified by sex and BMI categories were applied. Results 226 (0.29%) men and 79 (0.18%) women developed diabetes during 992,980 and 530,814 person-years follow-up, respectively, at a mean age of 30.4 and 27.4 years, respectively. Among native Israeli men with normal and high (overweight and obese) BMI, diabetes incidence was 9.5 and 62.0 (per 105 person-years), respectively. The respective incidences were 46.9 and 112.3 among men of Ethiopian origin. After adjustment for sociodemographic confounders, the hazard ratios for type 2 diabetes among Ethiopian men with normal and high BMI were 3.4 (2.3–5.1) and 15.8 (8.3–30.3) respectively, compared to third-generation Israelis with normal BMI. When this analysis was limited to Israeli-born Ethiopian men, the hazard ratios were 4.4 (1.7–11.4) and 29.1 (12.9–70.6), respectively. Results persisted when immigrants of other white Caucasian origin were the reference; and among women with normal, but not high, BMI. Conclusions Ethiopian origin is a risk factor for early-onset type 2 diabetes among young men at any BMI, and may require selective interventions.

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“…For individuals without a formal date, who were rst reported in 2013 or later, we assigned the date of diagnosis as July 1 st of the year before the report year to the INDR, as described previously. (10) Data collection and study variables Age at examination and year of birth were treated as continuous variables. The health examination was performed by military physicians who reviewed the participants' medical records and provided diagnostic codes when applicable.…”

Section: The Israel National Diabetes Registry (Indr) and Diagnosis Omentioning

confidence: 99%

Adolescent BMI and Early-Onset Type 2 Diabetes Among Ethiopian Immigrants and Their Descendants: A Nationwide Study.

Simchoni

Hamiel

Pinhas‐Hamiel

et al. 2020

Preprint

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Background: We assessed in a nationwide cohort the association between adolescent BMI and early-onset (<40 years) type 2 diabetes among Israelis of Ethiopian origin.Methods: Normoglycemic adolescents (range 16-20 years old), including 93,806 native Israelis (≥3rd generation in Israel) and 27,684 Israelis of Ethiopian origin, were medically assessed for military service between 1996 and 2011. Weight and height were measured. Data were linked to the Israeli National Diabetes Registry. Incident type 2 diabetes by December 31, 2016 was the outcome. Cox regression models stratified by sex and BMI categories were applied. Results: 226 (0.29%) men and 79 (0.18%) women developed diabetes during 992,980 and 530,814 person-years follow-up, respectively, at a mean age of 30.4 and 27.4 years, respectively. Among native Israeli men with normal and high (overweight and obese) BMI, diabetes incidence was 9.5 and 62.0 (per 105 person-years), respectively. The respective incidences were 46.9 and 112.3 among men of Ethiopian origin. After adjustment for sociodemographic confounders, the hazard ratios for type 2 diabetes among Ethiopian men with normal and high BMI were 3.4 (2.3-5.1) and 15.8 (8.3-30.3) respectively, compared to third-generation Israelis with normal BMI. When this analysis was limited to Israeli-born Ethiopian men, the hazard ratios were 4.4 (1.7-11.4) and 29.1 (12.9-70.6), respectively. Results persisted when immigrants of other white Caucasian origin were the reference; and among women with normal, but not high, BMI.Conclusions: Ethiopian origin is a risk factor for early-onset type 2 diabetes among young men at any BMI, and may require selective interventions.

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Adolescent Obesity and Early-Onset Type 2 Diabetes

Cited by 115 publications

References 46 publications

Socioeconomic inequalities and severe obesity—Sex differences in a nationwide study of 1.12 million Israeli adolescents

Socioeconomic inequalities and severe obesity—Sex differences in a nationwide study of 1.12 million Israeli adolescents

Adolescent BMI and early-onset type 2 diabetes among Ethiopian immigrants and their descendants: a nationwide study

Adolescent BMI and Early-Onset Type 2 Diabetes Among Ethiopian Immigrants and Their Descendants: A Nationwide Study.

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