Adolescent obesity and the role of the fat mass and obesity-associated gene polymorphism

Çöl, Nilgün; Demircioğlu-Kiliç, Beltinge; Nacak, Muradiye; Araz, Mustafa

doi:10.25011/cim.v40i6.29124

Cited by 3 publications

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References 31 publications

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“…Out of the 32 studies, nine studies were from China [ 43 , 46 , 49 , 50 , 52 , 53 , 55 , 56 , 60 ], three studies were from Spain [ 39 , 42 , 44 ], two studies were from India [ 35 , 45 ]. Other studies were once seen in the following countries: Iran [ 61 ], Iraq [ 64 ], Poland [ 58 ], Brazil [ 54 ], Italy [ 51 ], Mexico [ 41 ], Pakistan [ 48 ], Portugal [ 40 ], Russia [ 32 ], Sweden [ 31 ], Turkey [ 37 ], United Kingdom [ 36 ], Czech Republic [ 59 ], Germany [ 30 ], Austria [ 34 ], Chile [ 47 ], Egypt [ 38 ] and Indonesia [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

Genetic Variants in the Fat Mass and Obesity‐Associated Gene and Risk of Obesity/Overweight in Children and Adolescents: A Systematic Review and Meta‐Analysis

Eghbali,

Mottaghi,

Taghizadeh

et al. 2024

Endocrino Diabet & Metabol

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ObjectiveThe variations in the single‐nucleotide polymorphisms (SNPs) of the fat mass and obesity (FTO)‐associated gene have been linked to being overweight or obese in children. In this research a thorough examination was performed to elucidate the connection between various FTO gene SNPs and overweight or obesity in children and adolescents.MethodWe searched PubMed, Google scholar, Web of Science and Scopus until January 2024 to find studies that investigate the association between different SNPs of FTO gene and the risk of overweight/obesity in children and adolescents. After filtering the relevant studies, meta‐analysis was used to quantify the association of FTO gene SNPs within different genetic inheritance models.ResultsWe have identified 32 eligible studies with 14,930 obese/overweight cases and 24,765 healthy controls. Our recessive model showed a significant association with rs9939609 (OR: 1.56, 95% CI: 1.20; 2.02, p < 0.01) and rs1421085 (OR: 1.77, 95% CI: 1.14; 2.75, p < 0.01). Besides, in the homozygote model, rs1421085 showed the highest association (OR: 2.32, 95% CI: 1.38; 3.89, p < 0.01) with the risk of obesity in a population of children and adolescents. Moreover, there are other SNPs of FTO genes, such as rs9921255, rs9928094 and rs9930333, which showed a positive association with obesity and overweight. However, their effects were evaluated in very few numbers of studies.ConclusionIn this study, we have found that the FTO rs9939609 and rs1421085 are associated to an increased risk of obesity among children and adolescents. Besides, the findings of this study further reaffirmed the established link between rs9939609 and obesity in children and adolescents.

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Section: Resultsmentioning

confidence: 99%

Genetic Variants in the Fat Mass and Obesity‐Associated Gene and Risk of Obesity/Overweight in Children and Adolescents: A Systematic Review and Meta‐Analysis

Eghbali,

Mottaghi,

Taghizadeh

et al. 2024

Endocrino Diabet & Metabol

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“…One such study was carried out by Yang et al (2019), which demonstrated a significant impact of the SNP gene FTO rs9939609 on obesity. According to a study by Cho, persons with the SNP FTO rs9939609 genotype (AT+AA) had a greater BMI than those with the homozygous wild type (TT) genotype in a population in northwest China10 (Abdelmajed et al, 2017;çöl et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…A study on murine samples found that FTO rs9939609 has a role in the regulation of food intake and energy consumption by modifying appetite and food intake affecting the expression of NPY in the hypothalamus (Cho et al, 2021). Several studies also showed that there is a positive relationship between the mRNA level of the FTO gene in subcutaneous adipose tissue and BMI (Abdelmajed et al, 2017;çöl et al, 2017). The results of a meta-analysis study conducted by Maryam showed that there was an indication of carrier allele A of the FTO rs9939609 polymorphism on increased body fat percentage (BF%) (çöl et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Association of rs9939609 FTO Gene Polymorphism as a Risk Factor of Obesity in Adults

Pratamawati,

Sadji,

Brajadenta

et al. 2024

Global Health Management Journal

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Background: The cause of obesity is an imbalance between the number of calories taken and the amount burned. Obesity is a complex disease. The FTO rs9939609 gene polymorphism is one of the genetic factors that contribute to obesity in addition to environmental factors. Numerous researches have suggested a connection between the prevalence of obesity and the FTO rs9939609 gene polymorphism Aims: The purpose of this study is to ascertain how the FTO rs9939609 gene polymorphism relates to the prevalence of adult obesity. Methods: At the Biomolecular and Genetics Laboratory of the UGJ Faculty of Medicine, an analytical observational study using a case-control design was carried out with 84 participants, 42 subjects in case group, and 42 subjects in control groups. Data were collected utilizing DNA from blood collection, PCR-RFLP for genotyping, and 2.5% electrophoretic gel for visualization. Chi-square was used for data analysis. Results: Findings showed that there is no link between the FTO rs9939609 polymorphism and the prevalence of obesity (p>0.05, OR=0.710). Conclusion: In the Indonesian population, the FTO rs9939609 gene polymorphism is not associated with an increased risk of obesity.

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“…Sizes of data markers indicate the weight of each study in the analysis. Study-specific odds ratios were pooled using random-effects meta-analysis Col, 2017;Dusatkova, 2013;Liem 2010;Zhao 2014. were conducted in the young population (age <18 years).…”

mentioning

confidence: 99%

Common genetic variation in obesity, lipid transfer genes and risk of Metabolic Syndrome: Results from IDEFICS/I.Family study and meta-analysis

Nagrani

Foraita

Gianfagna

et al. 2020

Sci Rep

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As the prevalence of metabolic syndrome (MetS) in children and young adults is increasing, a better understanding of genetics that underlie MetS will provide critical insights into the origin of the disease. We examined associations of common genetic variants and repeated MetS score from early childhood to adolescence in a pan-european, prospective iDeficS/i.family cohort study with baseline survey and follow-up examinations after two and six years. We tested associations in 3067 children using a linear mixed model and confirmed the results with meta-analysis of identified SNPs. With a stringent Bonferroni adjustment for multiple comparisons we obtained significant associations(p < 1.4 × 10 −4 ) for 5 SNPs, which were in high LD (r 2 > 0.85) in the 16q12.2 non-coding intronic chromosomal region of FTO gene with strongest association observed for rs8050136 (effect size(β) = 0.31, p Wald = 1.52 × 10 −5 ). We also observed a strong association of rs708272 in CETP with increased HDL (p = 5.63 × 10 −40 ) and decreased tRG (p = 9.60 × 10 −5 ) levels. These findings along with meta-analysis advance etiologic understanding of childhood MetS, highlighting that genetic predisposition to MetS is largely driven by genes of obesity and lipid metabolism. inclusion of the associated genetic variants in polygenic scores for MetS may prove to be fundamental for identifying children and subsequently adults of the high-risk group to allow earlier targeted interventions.A collection of risk factors, including central obesity, insulin resistance, dyslipidemia, and hypertension, describes metabolic syndrome (MetS). Additionally, MetS is a known precursor in cardiovascular disease development 1 . MetS has become a major public health concern globally due to its increasing prevalence and association with various chronic diseases 2 . MetS etiology is quite complex, involving a strong interplay between multiple genetic, environmental and lifestyle-related factors. In European ancestry, the heritability of the MetS was estimated to be between 13-30% 3,4 . The early prognosis of MetS is therefore extremely valuable for early detection of individuals at high genetic risk of developing the disease later in life and for encouraging change in lifestyle to reduce risk. While numerous single nucleotide polymorphisms (SNPs) associated with individual metabolic components and diseases have been reported in genome-wide association studies (GWAS) 5-8 , the effect of these polymorphisms on the MetS network and related diseases is not well studied.Further, of all MetS components, lipid levels seem under higher genetic determination 9 . This has also been observed in the genetic association studies suggesting that genetic effects on lipid levels are more pronounced than for other traits 10 . Most of the genetic association studies for MetS have been conducted in adult population 5,10,11 and are limited by the usage of one-point measurements 7,[12][13][14] . As the prevalence of MetS in children and young adults is increasing 15 , a better understanding ...

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Adolescent obesity and the role of the fat mass and obesity-associated gene polymorphism

Cited by 3 publications

References 31 publications

Genetic Variants in the Fat Mass and Obesity‐Associated Gene and Risk of Obesity/Overweight in Children and Adolescents: A Systematic Review and Meta‐Analysis

Genetic Variants in the Fat Mass and Obesity‐Associated Gene and Risk of Obesity/Overweight in Children and Adolescents: A Systematic Review and Meta‐Analysis

Association of rs9939609 FTO Gene Polymorphism as a Risk Factor of Obesity in Adults

Common genetic variation in obesity, lipid transfer genes and risk of Metabolic Syndrome: Results from IDEFICS/I.Family study and meta-analysis

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