Adolescent Oral Methylphenidate Treatment Causes Post-administration Increase in Weight Gain and Hyperphagia with no Effect on Anxiety-related Behaviours in Rats
Abstract:Methylphenidate (MPH) is a widely abused drug that has been shown to be a neural stimulant, amidst concern that it could be neurotoxic. The present study evaluated the changes in body weight, food intake and anxiety-related behaviours following oral administration of MPH to adolescent rats. Thirty-two (32) male adolescent wistar rats were divided into two groups and orally administered either saline vehicle or MPH from post-natal day (PD) 30 twice daily for 14 days. Body weight and food intake were monitored d… Show more
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