IntroductionParent - young communication on sexual and reproductive health is one potential source of sexual and reproductive health information for young people. Lack of parent - young people communication was a serious problem in developing countries that resulted in emotional distress, lower self-esteem, school problems, drug use, and sexual risk behaviors. Assessing the the reasons and challenges of parents to young people communication about a sexual and reproductive health issue is the most effective way to prevent preexisting misbehavior in young people. ObjectiveThe study aimed to assess reason not to discuss and challenges of parent-young communication, and associated factors on sexual and reproductive health among parent living with young in North Gondar zone, northwest Ethiopia 2021. MethodsA Community based cross-sectional mixed qualitative study was conducted on 1000 parents of youngs for quantitative and 2FGD and 25 in-depth interviews were included with a diversity of parents and students. Data were collected using a pre-tested and semi-structured questionnaire through face-to-face interviews, FGD, and in-depth interviews. A bivariate and a multivariable logistics regression model was fitted for the quantitative part and individual in-depth interview and focus group discussion will be tape-recorded after verbal consent will be granted and finally translated and transcribed by the data collectors. Thematic analysis will be used to analyze the qualitative data based on emerging themes and sub-themes in line with the study objectives. ResultAccording to this study parent to young communication was found to be11.4 %( 95% CI:9.5,13). Multivariable analysis revealed that, residence (AOR=2.1 95%CI 1.15,9.34), sex (AOR=2.4,95% CI2.11,4.33), knowledge (AOR =3.8, 95% CI2.7,6.34),attitude(AOR=2.2, 95% CI 1.44,4.32) Father’s educational status (AOR=4.3, 95%CI 1.8, 4.56), mother educational status (AOR=2.4,95% CI 1.23, 4.12) number of children (AOR=3,95% CI 2.6,4.74) and age (AOR=3.22,95%CI 2.8, 4.9) were statistically significant associated factors on parent to young people communication.Conclusion and recommendationparent to young communication was low in this study as compared to other studies done in different pockets of Ethiopia. Successively, promotion of parent to young people communication and addressing the importance of parent to young people communication to all parents along with HEW was recommended