Adolescent Psychiatric Symptoms Following Preschool Childhood Mild Traumatic Brain Injury

McKinlay, Audrey; Grace, Randolph C.; Horwood, L. John; Fergusson, David M.; MacFarlane, Martin R.

doi:10.1097/htr.0b013e3181a40590

Cited by 160 publications

(119 citation statements)

References 44 publications

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“…However, two recent longitudinal investigations conducted in New Zealand and Germany, respectively, concluded that TBI is not likely to cause neurocognitive impairment in children and adolescent (18,19). The discrepancy between our study and these two investigations may be explained by differences in study designs and the environmental characteristics of the target populations.…”

Section: Articlescontrasting

confidence: 54%

“…In addition, several studies have suggested that children with moderate to severe TBI are significantly more likely to develop ADHD symptoms than are those with mild TBI (8,(13)(14)(15)(16)(17). A longitudinal birth cohort study reported no association between preschool mild TBI and ADHD after adjusting for potential covariates (18). Nevertheless, a prospective cohort study reported that children with mild TBI have a higher risk of hyperactivity in the first year after injury (19).…”

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confidence: 90%

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Association of traumatic brain injury in childhood and attention-deficit/hyperactivity disorder: a population-based study

et al. 2016

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Background:We evaluated the risk of attention-deficit hyperactivity disorder (ADHD) following childhood traumatic brain injury (TBI). Methods: Using Taiwan's National Health Insurance Research Database, we included 10,416 newly diagnosed TBI children (aged ≤12 y) between 2001 and 2002 and 41,664 children without TBI, who were frequency matched by sex, age, and year of the index medical service with each TBI child, as controls. Children who had been diagnosed with ADHD prior to their medical service index were excluded. Each individual was followed for 9 y to identify ADHD diagnosis. We also compared the ADHD risk in children who were treated for fractures but not TBI as sensitivity analysis. results: During the 9-y follow-up period, children with TBI had a higher ADHD risk (adjusted hazard ratio (AHR) = 1.32, 95% confidence interval (CI) = 1.19, 1.45) than did those without TBI. Furthermore, children with mild and severe TBI had higher AHRs for ADHD than did those without TBI (AHR = 1.30; 95% CI = 1.10, 1.53; and AHR = 1.37; 95% CI = 1.22, 1.55). However, no significant association was observed between fractures and ADHD. conclusion: TBI in childhood is associated with a greater likelihood of developing ADHD. t raumatic brain injury (TBI) is the leading cause of death and disability in children and often results in persistent behavioral disturbances and neurocognitive deficits in attention, learning, and memory (1-3). Children with cognitive impairment following TBI impose a great economic and social burden on their families and communities. In addition, these children are more likely to have slower psychosocial development and exhibit poor academic achievement. Therefore, the relationship between TBI and neuropsychiatric consequences has become a crucial research topic.Attention-deficit-hyperactivity disorder (ADHD), a neurodevelopmental disorder, is associated with impulsivity, excessive talking, difficulty in sustaining attention, being easily distracted, and injuries (4-6). Studies have reported a relationship between ADHD and childhood TBI (7-10). Unlike other diseases resulting from various pathogenic mechanisms, TBI is caused by a complex interplay among damages occurring in the neuroanatomy, neurochemistry, and neurophysiology because of primary and secondary processes (11). A meta-analytic review showed that neurocognitive outcomes after pediatric TBI have a dose-response relationship with injury severity. Babikian and colleagues found that patients with severe TBI exhibited poorer performance in intelligence quotient tests, executive functioning, processing speed, attention maintenance, verbal immediate memory, and delayed memory, whereas patients with mild TBI exhibited no change (12). In addition, several studies have suggested that children with moderate to severe TBI are significantly more likely to develop ADHD symptoms than are those with mild TBI (8,(13)(14)(15)(16)(17). A longitudinal birth cohort study reported no association between preschool mild TBI and ADHD after adjusting for potential co...

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Section: Articlescontrasting

confidence: 54%

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confidence: 90%

Association of traumatic brain injury in childhood and attention-deficit/hyperactivity disorder: a population-based study

et al. 2016

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“…A similar line of research which explores a potentially indirect mechanism in the relationship between TBI and crime focuses on mental illness following brain injury. These studies suggest that those with TBI, including both adolescents and adults, are more likely to have symptoms of a psychiatric disorder (e.g., ADHD, bipolar disorder, major depression, panic disorder, depression) as well as increased aggressive behaviors at follow-up (Bloom et al, 2001;Cole et al, 2008;Dinn, Gansler, Moczynski, & Fulwiler, 2009;Gerring et al, 2009;Hesdorffer, Rauch, & Tamminga, 2009;Koponen, 2005;Max, Castillo, Lindgren, & Arndt, 1998;Max, Robertson, & Lansing, 2001;McKinlay, Grace, Horwood, Fergusson, & MacFarlane, 2009;VanReekum, Bolago, Finlayson, Garner, & Links, 1996). Thus, having TBI might also result in symptoms of mental illness, substance abuse, or violence which could exacerbate the likelihood of arrest.…”

Section: Traumatic Brain Injury and Criminal Behaviormentioning

confidence: 99%

Traumatic Brain Injury and Recidivism Among Returning Inmates

Ray

Richardson

2017

Criminal Justice and Behavior

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In recent years, there has been a surge in research that examines the relationship between traumatic brain injury (TBI) and involvement in the criminal justice system. However, the bulk of this research has been largely retrospective and descriptive, comparing rates of TBI in the offending population with the rates of TBI in the general population. Although findings from these studies indicate a higher prevalence of TBI in the offending population, virtually no studies have examined whether those with TBI are more likely to recidivate. To address this gap, the present study examined rearrest post release from prison among a cohort sample of Indiana inmates who were screened using the Ohio State University Traumatic Brain Injury Identification (OSU-TBI-ID) instrument. Findings indicate that, net of control variables, those with TBI were more likely to recidivate sooner than those without TBI. Policy implications and directions for future research are discussed.

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“…Specifically, animal models of repeated pmTBI indicate increased memory impairment, astrocytic reactivity, and axonal injury relative to a single injury model (Prins et al, 2010). Preliminary evidence of increased deficits after a quick return to play after pmTBI also exists in human injury models as well (McCrory et al, 2009;Guskiewicz and Valovich McLeod, 2011;Lincoln et al, 2011). The current definition of mTBI is variable (Ruff et al, 2009;Rosenbaum and Lipton, 2012) and primarily determined by clinical observations and selfreported symptomatology rather than objective criteria.…”

Section: Figurementioning

confidence: 99%

“…In summary, pmTBI is associated with an increased incidence of neuropsychiatric conditions (McKinlay et al, 2009), delays in academic achievement, and decrease in overall quality of health (Yeates et al, 2012). Understanding the neuropathological underpinnings of these deficits is critical for both diagnostic considerations and developing novel treatment strategies.…”

Section: Figurementioning

confidence: 99%

Diffusion Abnormalities in Pediatric Mild Traumatic Brain Injury

et al. 2012

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Pediatric mild traumatic brain injury (pmTBI) is the most prevalent neurological insult in children and is associated with both acute and chronic neurobehavioral sequelae. However, little is known about underlying pathophysiology and how injuries change as a function of recovery. Fractional anisotropy, axial diffusivity, and radial diffusivity were examined in 15 semi-acute pmTBI patients and 15 wellmatched controls, with a subset of participants returning for a second visit. A novel analytic strategy was applied to capture spatially heterogeneous white matter injuries (lesions) in addition to standard analyses. Evidence of cognitive dysfunction after pmTBI was observed in the domains of attention (p ϭ 0.02, d ϭ Ϫ0.92) and processing speed (p ϭ 0.05, d ϭ Ϫ0.73) semi-acutely. Region of interest (ROI) and voxelwise analyses indicated increased anisotropic diffusion for pmTBI patients, with an elevated number of clusters with high anisotropy. Metrics of increased anisotropy were able to objectively classify pmTBI from healthy controls at 90% accuracy but were not associated with neuropsychological deficits. Little evidence of recovery in white matter abnormalities was observed over a 4-month interval in returning patients, indicating that physiological recovery may lag behind subjective reports of normality. Increased anisotropic diffusion has been previously linked with cytotoxic edema after TBI, and the magnitude and duration of these abnormalities appear to be greater in pediatric patients. Current findings suggest that developing white matter may be more susceptible to initial mechanical injury forces and that anisotropic diffusion provides an objective biomarker of pmTBI.

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Adolescent Psychiatric Symptoms Following Preschool Childhood Mild Traumatic Brain Injury

Abstract: Preschool MTBI is associated with persistent negative effects on psychosocial development. These continuing problems are consistent with the view that preschool years represent a period of particular vulnerability following MTBI.

Cited by 160 publications

References 44 publications

Association of traumatic brain injury in childhood and attention-deficit/hyperactivity disorder: a population-based study

Association of traumatic brain injury in childhood and attention-deficit/hyperactivity disorder: a population-based study

Traumatic Brain Injury and Recidivism Among Returning Inmates

Diffusion Abnormalities in Pediatric Mild Traumatic Brain Injury

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