Adolescent “Saxophone Penis” Secondary to Crohn's Disease: Misdiagnosed as Being Posttraumatic

Marshall, Claire; D, Markiewicz; Bewley, Anthony

doi:10.1111/pde.12725

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…4 Metastatic Crohn disease presenting as severe penile edema is rare and should be suspected in patients with a history of Crohn disease, also considering that the genital symptoms may antedate the gastrointestinal manifestations in 25% of cases. 5,6 In fact, 8 patients with genital metastatic Crohn disease were reported from Mayo Clinic (mean age 11.4 years, range 7-16), 7 of whom experienced penile and scrotal swelling before a diagnosis of Crohn disease was made, and 2 of the 7 presented no gastrointestinal symptoms. 7 Histopathology showing noncaseating granulomas such as that of the gastrointestinal Crohn disease is diagnostic, but the granulomas may be focal, small, and therefore may be overlooked if there is not a clinical suspicion of Crohn disease.…”

Section: Discussionmentioning

confidence: 99%

Clinical Pathologic Challenge Saxophone Penis: Challenge

Stabile

Guida

Allocca

et al. 2023

The American Journal of Dermatopathology

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Section: Discussionmentioning

confidence: 99%

Clinical Pathologic Challenge Saxophone Penis: Challenge

Stabile

Guida

Allocca

et al. 2023

The American Journal of Dermatopathology

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Pediatric cutaneous Crohn disease: A case series of 89 patients and review

McKay,

Liu,

Shaw

et al. 2024

Pediatric Dermatology

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BackgroundCutaneous (or “Metastatic”) Crohn disease (CCD) is a rare and underrecognized disease characterized by cutaneous granulomatous inflammation. We describe patient demographics, clinical characteristics, histology, and treatment of 89 pediatric cases of CCD, including 78 previously reported and 11 new cases seen at four academic institutions. We emphasize the efficacy of biologic mono‐ and dual therapy.MethodsPubMed identified cases using keywords including “metastatic Crohn disease” and “cutaneous Crohn disease”. Patients were identified by retrospective review of the electronic health record including histopathologic diagnosis consistent with CCD. Chart review collected demographic, clinical, and histologic data.ResultsMost pediatric patients with CCD are male 55% (49/89), present with edema (73/89, 82%) and erythema (47/89, 53%) of the genitals (33/49, 67%), and have intestinal Crohn disease (69/89, 78%). Oral corticosteroids (53/75, 71%) and metronidazole (29/75, 39%) are the most frequently prescribed medications. Of the 17 patients treated with tumor necrosis factor (TNF)‐blockade, 94% (16/17) had partial or total clearance. Ustekinumab resulted in clearance of cutaneous disease in two patients (2/3, 67%) and partial clearance in one patient (1/3, 33%). Two cases achieved total clearance with the use of dual biologic therapy defined as the use of two biologic therapies with differing mechanisms of action or the use of a biologic therapy and small molecule inhibitor.ConclusionsTNF blockade is an effective treatment for pediatric CCD, and interleukin‐12/23 inhibitors may be similarly effective. Consideration of dual biologic therapy may be useful in pediatric patients requiring discordant therapies for their intestinal and cutaneous CD.

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Classifying Hydroceles of the Pelvis and Groin: An Overview of Etiology, Secondary Complications, Evaluation, and Management

Dagur¹,

Gandhi²,

Suh³

et al. 2017

Current Urology

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Introduction: A hydrocele is defined as the pathological buildup of serous fluid in the pelvis and groin due to various etiologies such as diseases or trauma. It has distinct clinical manifestations, particularly discomfort and psychosocial distress. Understanding the anatomy, embryology, and physiology associated with hydrocele formation is crucial to understand its onset and progression. Materials and Methods: A MEDLINE^® search was conducted using keywords for the relevant classification of hydrocele and its etiology, complications, sexual barriers, evaluation, and management. Results: Appropriately classifying the hydrocele as primary, secondary communicating, secondary noncommunicating, microbe-induced, inflammatory, iatrogenic, trauma-induced, tumor-induced, canal of Nuck, congenital, and giant is important for identifying the underlying etiology. Often this process is overlooked when the classification or etiology is too rare. A focused evaluation is important for this, so that timely management can be provided. We comprehensively review the classifications, etiology, and secondary complications of hydrocele. Pitfalls of current diagnostic techniques are explored along with recommended methods for accurate diagnosis and current treatment options. Conclusion: Due to the range of classifications and etiologies of hydrocele in the pelvis and groin, a deliberate differential diagnosis is essential to avoiding imminent life-threatening complications as well as providing the appropriate treatment.

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Adolescent “Saxophone Penis” Secondary to Crohn's Disease: Misdiagnosed as Being Posttraumatic

Cited by 3 publications

References 6 publications

Clinical Pathologic Challenge Saxophone Penis: Challenge

Clinical Pathologic Challenge Saxophone Penis: Challenge

Pediatric cutaneous Crohn disease: A case series of 89 patients and review

Classifying Hydroceles of the Pelvis and Groin: An Overview of Etiology, Secondary Complications, Evaluation, and Management

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