Adolescent subthreshold‐depression and anxiety: psychopathology, functional impairment and increased suicide risk

Balázs, Judit; Miklósi, Monika; Keresztény, Ágnes; Hoven, Christina W.; Carli, Vladimir; Wasserman, Camilla; Apter, Alan; Bobes, Julio; Brunner, Romuald; Cosman, Doina; Cotter, Pádraig; Häring, Christian; Iosue, Miriam; Kaess, Michael; Kahn, Jean‐Pierre; Keeley, Helen; Marušič, Dragan; Poštuvan, Vita; Resch, Franz; Sáiz, Pilar A.; Sisask, Merike; Snir, Avigal; Tubiana, Alexandra; Värnik, Airi; Sarchiapone, Marco; Wasserman, Danuta

doi:10.1111/jcpp.12016

Cited by 442 publications

(278 citation statements)

References 46 publications

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“…The multi-centre Saving and Empowering Young Lives in Europe (SEYLE) study reported that 5.8% of participants met criteria for an anxiety disorder, 10.5% met criteria for depressive disorder [15], while 32.3% reported suicidal thoughts [16]. In this study we examined physical activity and its associations with mental health indicators in the SEYLE sample.…”

Section: Introductionmentioning

confidence: 99%

Physical activity in European adolescents and associations with anxiety, depression and well-being

McMahon

Corcoran

O’Regan

et al. 2016

Eur Child Adolesc Psychiatry

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449

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In this cross-sectional study, physical activity, sport participation and associations with wellbeing, anxiety and depressive symptoms were examined in a large representative sample of European adolescents. A school-based survey was completed by 11,110 adolescents from ten European countries who took part in the SEYLE (Saving and Empowering Young Lives in Europe) study. The questionnaire included items assessing physical activity, sport participation and validated instruments assessing well-being (WHO-5), depressive symptoms (BDI-II) and anxiety (SAS). Multilevel mixed effects linear regression was used to examine associations between physical activity/sport participation and mental health measures. A minority of the sample (17.9% of boys and 10.7% of girls; p<0.0005) reported sufficient activity based on WHO guidelines (60 minutes+ daily).The mean number of days of at least 60 minutes of moderate-to-vigorous activity in the past two weeks was 7.5±4.4 among boys and 5.9 days±4.3 among girls. Frequency of activity was positively correlated with wellbeing and negatively correlated with both anxiety and depressive symptoms, up to a threshold of moderate frequency of activity. In a multi-level mixed effects model more frequent physical activity and participation in sport were both found to independently contribute to greater wellbeing and lower levels of anxiety and depressive symptoms in both sexes. Increasing activity levels and sports participation among the least active young people should be a target of community and school-based interventions to promote well-being. There does not appear to be an additional benefit to mental health associated with meeting the WHO-recommended levels of activity.

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Section: Introductionmentioning

confidence: 99%

Physical activity in European adolescents and associations with anxiety, depression and well-being

McMahon

Corcoran

O’Regan

et al. 2016

Eur Child Adolesc Psychiatry

Self Cite

449

282

View full text Add to dashboard Cite

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“…One recent meta-analysis found the worldwide prevalence of depressive disorder in youth to be 2.6 % (Polanczyk et al 2015), with other work showing about one third of adolescents manifesting subthreshold depression (Balazs et al 2013). Both adolescent subthreshold depression and depressive disorder are associated with severe functional impairments (Fröjd et al 2008), elevated rates of substance abuse (Diego et al 2003), increased likelihood of adult depression (Pine et al 1999), and poor physical health (Naicker et al 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Both adolescent subthreshold depression and depressive disorder are associated with severe functional impairments (Fröjd et al 2008), elevated rates of substance abuse (Diego et al 2003), increased likelihood of adult depression (Pine et al 1999), and poor physical health (Naicker et al 2013). Another severe consequence of adolescent depression is suicide (Wild et al 2004), with more than half of adolescent suicide victims having a depressive disorder at the time of death (Thapar et al 2012), and subthreshold-depressed adolescents being three times more likely to have suicidal thoughts/ideations than their non-depressed counterparts (Balazs et al 2013). Given these data on the prevalence and consequences of adolescent depression, identifying its etiological mechanisms is critical for developing empiricallybased prevention and intervention programs (Garber 2006).…”

Section: Introductionmentioning

confidence: 99%

The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model

Zhang

Chen

et al. 2015

J Youth Adolescence

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Although depressive symptoms are common during adolescence, little research has examined gene-environment interaction on youth depression. This study chose the brain-derived neurotrophic factor (BDNF) gene, tested the interaction between a functional polymorphism resulting amino acid substitution of valine (Val) to methionine (Met) in the proBDNF protein at codon 66 (Val66Met), and maternal parenting on youth depressive symptoms in a sample of 780 community adolescents of Chinese Han ethnicity (aged 11-17, M = 13.6, 51.3 % females). Participants reported their depressive symptoms and perceived maternal parenting. Results indicated the BDNF Val66Met polymorphism significantly moderated the influence of maternal warmth-reasoning, but not harshness-hostility, on youth depressive symptoms. Confirmatory model evaluation indicated that the interaction effect involving warmth-reasoning conformed to the differential-susceptibility rather than diathesis-stress model of person-X-environment interaction. Thus, Val carriers experienced less depressive symptoms than Met homozygotes when mothering was more positive but more symptoms when mothering was less positive. The findings provided evidence in support of the differential susceptibility hypothesis of youth depressive symptoms and shed light on the importance of examining the gene-environment interaction from a developmental perspective.

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“…Se calcula que la prevalencia de vida entre los 13 y los 18 años es de 14,3% para los trastornos del estado de ánimo y de 31,9% para los trastornos de ansiedad (Merikangas et al, 2010). Esta estimación tiene en cuenta exclusivamente los casos de trastorno franco, a los que debemos adicionar los estados de malestar subclínicos (Balázs et al, 2013).…”

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El consumo de tabaco como automedicación de depresión/ansiedad entre los jóvenes: resultados de un estudio con método mixto

et al. 2015

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Adolescent subthreshold‐depression and anxiety: psychopathology, functional impairment and increased suicide risk

Cited by 442 publications

References 46 publications

Physical activity in European adolescents and associations with anxiety, depression and well-being

Physical activity in European adolescents and associations with anxiety, depression and well-being

The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model

El consumo de tabaco como automedicación de depresión/ansiedad entre los jóvenes: resultados de un estudio con método mixto

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