Adolescent twins discordant for major depressive disorder: shared familial liability to externalizing and other internalizing disorders

Burcusa, Stephanie L.; Iacono, William G.

doi:10.1111/1469-7610.00184

Cited by 17 publications

(14 citation statements)

References 38 publications

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Section: Family History Of Psychopathologymentioning

confidence: 99%

“…For example, it could be that the affective disorders alone are responsible for the connection between family history of psychopathology and recurrence of depression; alternatively it could be that anxiety disorders or substance use disorders, for example, are also related to recurrence. In addition, studies of this type must be performed on genetically informative samples in order to account for the high comorbidity and familial liability between depression and other forms of psychopathology (Burcusa, Iacono, & McGue, 2003;Kendler et al, 1995;Kessler et al, 1996;Krueger, 1999).There are different mechanisms through which a family history of psychopathology could be related to recurrence of depression. The results of family studies suggest that the familial transmission of recurrent depression is even stronger than the familial transmission of depression in general (Klein, Lewinsohn, Rohde, Seeley, & Durbin, 2002;Zubenko et al, 2001), particularly if it is early-onset recurrent depression (Moldin, Reich, & Rice, 1991).…”

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confidence: 99%

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Risk for recurrence in depression

Burcusa

Iacono

2007

Clinical Psychology Review

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867

683

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Depression is a highly recurrent disorder with significant personal and public health consequences. Prevention of recurrence would be extremely desirable, and thus researchers have begun to identify risk factors that are specific to recurrence, which may be different from risk factors for first-onset of depression. Methodological issues in this area of research are briefly reviewed (e.g., the various definitions of "recurrence" and "depression"), followed by a review of studies on specific risk factors, including demographic variables (gender, socio-economic status, marital status), clinical variables (age at first onset, number of prior episodes, severity of first/index episode, comorbid psychopathology), family history of psychopathology, and psychosocial and psychological variables (level of psychosocial functioning, cognitions, personality, social support, and stressful life events). In addition, scar theories are evaluated for their potential to explain how these variables and recurrent depression are linked. Our review suggests that recurrent depression reflects an underlying vulnerability that is largely genetic in nature and that may predispose those high in the vulnerability not only to recurrent depressive episodes, but also to the significant psychosocial risk factors that often accompany recurrent depression.Major depressive disorder is one of the most common forms of psychopathology, one that will affect approximately one in six men and one in four women in their lifetimes . It is also usually highly recurrent, with at least 50% of those who recover from a first episode of depression having one or more additional episodes in their lifetime, and approximately 80% of those with a history of two episodes having another recurrence (American Psychiatric Association, 2000;Kupfer, Frank, & Wamhoff, 1996;Post, 1992). Once a first episode has occurred, recurrent episodes will usually begin within five years of the initial episode (Belsher & Costello, 1988;Lewinsohn, Clarke, Seeley, & Rohde, 1994), and, on average, individuals with a history of depression will have five (Kessler & Walters, 1998) to nine (Kessler, Zhao, Blazer, & Swartz, 1997) separate depressive episodes in their lifetime.Due to the fact that depression can be so recurrent, it can have significant personal and public health consequences. For example, one meta-analysis found that the suicide rate among those with depression is approximately twenty times higher than the rate for the general population (Harris & Barraclough, 1997). In addition, a study of over 3000 adolescents and young adults found that 90% of those with recurrent depression reported "very much" impairment, limiting work productivity and social interactions, and 40% sought professional help as a result (Wittchen, Nelson, & Lachner, 1998). Depression can also have a significant economic impact due to decreased productivity in affected individuals (Klerman & Weissman, 1992); in 1996 the annual direct (e.g., visits to doctors, pharmaceutical costs) and indirect (e.g., time...

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Section: Family History Of Psychopathologymentioning

confidence: 99%

mentioning

confidence: 99%

Risk for recurrence in depression

Burcusa

Iacono

2007

Clinical Psychology Review

Self Cite

867

683

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“…Since MZ and DZ twins did not differ in their prevalence rates of CP or any of the COPCs or chronic pain conditions, all study analyses were conducted with MZ and DZ pairs combined. Combining MZ and DZ twins in the absence of zygosity differences is common in discordant twin studies (24, 25). We followed a multiple step analytic procedure to examine the association of CP and COPCs and determine if evidence of familial confounding exists (26).…”

Section: Methodsmentioning

confidence: 99%

Chronic prostatitis and comorbid non-urological overlapping pain conditions: A co-twin control study

Gasperi

Krieger

Forsberg³

et al. 2017

Journal of Psychosomatic Research

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Objectives Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is characterized by pain and voiding symptoms in the absence of an obvious infection or other cause. CP/CPPS frequently occurs with non-urological chronic overlapping pain conditions (COPCs) of unknown etiology. We conducted a co-twin control study in men discordant for chronic prostatitis (CP), an overarching diagnosis of which approximately 90% is CP/CPPS. The primary aim was to investigate the contribution of familial factors, including shared genetic and common environmental factors, to the comorbidity of CP and COPCs. Methods Data from 6824 male twins in the Vietnam Era Twin Registry were examined to evaluate the association between self-reported lifetime physician diagnosis of CP with COPCs including fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, temporomandibular disorder, tension headaches, and migraine headaches. Random effects logistic regression models were used and within-pair analyses evaluated confounding effects of familial factors on the associations. Results There were significant associations between CP and all 6 examined COPCs. After adjusting for shared familial influences in within twin pair analyses, the associations for all COPCs diminished but remained significant. Familial confounding was strongest for the association of CP with fibromyalgia and temporomandibular disorder and smallest for irritable bowel syndrome. Conclusions CP and COPCs are highly comorbid. These associations can be partially explained by familial factors. The mechanisms underlying these relationships are likely diverse and multifactorial. Future longitudinal research can help to further elucidate specific genetic and environmental mechanisms and determine potentially causal relationships between CP and its comorbidities.

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“…Biometric models developed with our 17-year-old twins indicate that conduct disorder, antisocial personality disorder, adolescent/adult antisocial behavior (AAB; a syndrome characterized by the presence of ASPD antisocial behaviors with onset after age 15), nicotine dependence, alcohol use disorders, illicit drug use disorders, and the personality trait constraint all load strongly on this latent factor (Burcusa et al, 2003;Hicks et al, 2004;McGue et al, 2006). In the parents of MTFS twins, who are over the age of maximal risk for the development of externalizing psychopathology, direct comparisons of categorical and dimensional models of the latent externalizing liability demonstrated that the liability is continuous and graded, as opposed to delineating discrete categories of psychopathology in nature .…”

Section: Behavioral Disinhibition In Late Adolescence and Early Adultmentioning

confidence: 99%

“…Our assessment protocol covers negative emotionality, including associated personality traits, major depression, and anxiety disorders. Although our work has begun to explore the relationship between the development of SUDs, negative emotion (Elkins et al, 2006, and internalizing psychopathology (Burcusa et al, 2003;Herndon & Iacono, 2005;King et al, 2004;Marmorstein & Iacono, 2003, 2004, we hope to expand our efforts in this important domain.…”

Section: Future Directionsmentioning

confidence: 99%