“…6,13,15, Of these, nine were RCTs, 6,13,17,18,23,24,30,34,39 six were CCTs, 25,26,33,[36][37][38] one was a case series, 29 eight were prospective observational studies, 15,19,27,28,31,32,35,40 and three were qualitative studies. [20][21][22] The vast majority of included studies were carried out in a university or hospital setting apart from four studies were undertaken in private practices. 13,24,33,40 The appliances used varied significantly, with some studies evaluating a single treatment and others comparing two or three different types of Class II correction appliances (Appendix 3; Table II).…”