Adolescents' home pain management after laparoscopic appendectomy: preliminary results

Karamessinis, Laurie; Cooper, J.; Manworren, Renee C.B.

doi:10.1016/j.jpain.2013.01.668

Cited by 1 publication

(3 citation statements)

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“…Well known to clinicians is the tremendous variability of patients' experiences of pain. For example, our clinical research provides evidence of this variability in subjective reports of pain intensity among adolescents experiencing postoperative pain (Figure 1; Karamessinis et al, 2013;Manworren et al, 2014Manworren et al, , 2013Manworren, Paulos, & Pop, 2004). However, knowledge of patient characteristics and variables that increase risk for more severe postoperative pain is limited.…”

Section: Pain Sensitivity Genesmentioning

confidence: 89%

“…In our studies of analgesic needs to treat postoperative pain, we found tremendous variation in pediatric patients’ analgesic requirements to achieve optimal pain relief (Karamessinis, Cooper, & Manworren, 2013; Manworren et al., 2014; Manworren, Karamessinis, & Cooper, 2013; Pop et al, 2007). Deficiencies in current knowledge of analgesic efficacy in pediatrics have been identified (Berde et al, 2012; Gregoire & Finley, 2007).…”

Section: Genetic Variation In Responses To Pain Medicationsmentioning

confidence: 99%

“…For example, we currently cannot predict which patients are at the greatest risk for pain or persistent post-surgical pain, which patients are at greatest risk for adverse analgesic effects, or which patients are at greatest risk for opioid addiction. Instead, pain medications are prescribed based on patient weight, perceived seriousness of illness and invasiveness of surgical procedure, with little regard for individual patient genetic suitability (Diatchenko et al, 2006; Filligim et al, 2009; Kim et al, 2004; Logan & Rose, 2005; Karamessinis, Cooper, & Manworren, 2013; Manworren, Karamessinis, & Cooper, 2013; Mogil, 2004; Pinto et al, 2013; Rakvag et al, 2005). …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Translating the Human Genome to Manage Pediatric Postoperative Pain

Manworren

Ruaño

Young

et al. 2015

Journal of Pediatric Surgical Nursing

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Postoperative pain management is complex especially in the pediatric population where limited research exists to guide clinical practice. We currently cannot predict which children are at the greatest risk for pain, persistent postoperative pain, adverse analgesic effects, or opioid addiction. Instead, pain medications are prescribed based on perceived seriousness of the patient's illness/procedure, with little regard for individual genetic suitability. For the pediatric patient, personalized medicine has the potential to improve pain management and reduce risks of adverse analgesic effects, including opioid addiction. The purpose of this review article is to inform pediatric surgical nurses about the current status of genetic research related to pain sensitivity, genetic variants that affect analgesic metabolism, and the genetics of addiction. Application of this information in clinical practice remains merely a possibility; yet, vendors have begun to market genetic testing without clear guidelines for clinical interpretation. Genetic research efforts are progressing at a rapid pace, and the pediatric surgical specialist must be aware of both the potential implications for postoperative pain management as well as the current limitations given the level of research that is available to guide practice.

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Section: Pain Sensitivity Genesmentioning

confidence: 89%