Background. Self-reported school satisfaction is an important indicator of child and adolescent well-being. Few studies have examined how disability, gender, and age affect school satisfaction. Aim. We sought to determine whether the interaction between disability and gender with regard to self-reported school satisfaction might be specific to particular types of disability and particular ages. Methods. We undertook secondary analysis of Waves 5 and 6 of the UK's Millennium Cohort Study (MCS), a nationally representative sample of children born 2000-2002. MCS is the fourth in the series of British birth cohort studies. Result. At 11 years of age (n = 12,207), school satisfaction was significantly higher for girls and those without disabilities. By contrast, at 14 (n = 10,933), school satisfaction was significantly higher for boys and those without disabilities. Subsequent analyses of gender moderation of the association between disability and school satisfaction revealed a significant interaction between gender and disabilities associated with mental health and with dexterity, respectively, at 14 years but not at age 11. Conclusion. These findings will inform future research endeavours, policy, and practice in psychology, education, and other areas associated with child development and disability. One important indicator of child and adolescent well-being is school satisfaction. A seminal national study conducted in the United States stated 'Of the constellation of forces that influence adolescent health-risk behaviour, the most fundamental are the social contexts in which adolescents are embedded; the family and school contexts are among the most critical' (Resnick et al., 1997, p. 823). This has been reiterated numerous times in the literature including a recent report from the World Health Organization study of Health Behaviour in School-aged Children (HBSC) which states that liking school serves as a 'protective factor against health-compromising behaviors' whereas not liking school 'is associated with health-risk behaviors, low self-rated health and increased somatic and This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.