Adolescents, young adults, and cancer—the international challenge

Barr, Ronald D.

doi:10.1002/cncr.26052

Cited by 55 publications

(39 citation statements)

References 39 publications

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“…Although the time period in our study differed, the overall cancer survival rate among AYAs in Korea was similar to the rate and significantly improvement reported in the U.S. and Germany. Improvements in relative survival rates among AYAs can be partially explained by advances in cancer detection, more intensive treatments, and increased expertise in adolescent oncology [38]. Additionally, access to effective protocols and the development of health infrastructures may have also contributed to improvements in survival rates [39].…”

Section: Discussionmentioning

confidence: 99%

Cancer Incidence and Survival among Adolescents and Young Adults in Korea

Moon

Park

et al. 2014

PLoS ONE

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BackgroundIn Korea, cancer is the third leading cause of death among adolescents and young adults (AYAs). However, cancer incidence and survival trends among AYAs (15–29 years) have never been studied in Korea. Therefore, this study aimed to investigate the incidence and relative survival rates and their trends among AYAs in Korea.Materials and MethodsCancer incidence data from 1999–2010 were obtained from the Korea Central Cancer Registry (KCCR). Each cancer was classified into subgroups according to the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) AYA site recode. Percent distributions, age-specific incidence rates, age-standardized incidence rates per million, and annual percent changes (APCs) were calculated for AYAs according to sex. Five-year relative survival rates were estimated for cases diagnosed between 1993 and 2010 and followed up to 2011.ResultsThe age-standardized incidence rates of all cancers combined were 196.4 and 367.8 per million for males and females, respectively (male-to-female (M/F) ratio: 0.5). The age-standardized incidence rates increased from 208.7 per million in 1999 to 396.4 per million in 2010, and the APC was 6.3% (P<0.001). The five most common cancers among AYAs were thyroid carcinoma, non-Hodgkin lymphoma, stomach carcinoma, breast carcinoma, and acute myeloid leukemia. In males, the 5-year relative survival rate improved, from 46.5% in 1993–1995 to 75.9% in 2006–2010. In females, the 5-year relative survival rate also improved, from 66.7% in 1993–1995 to 89.1% in 2006–2010.ConclusionsOur study showed increases in cancer incidence and improvements in the 5-year relative survival rate among Korean AYAs. This study also provides additional data regarding temporal and geographic trends in cancer that may enhance future efforts to identify factors affecting cancer incidence and responses to treatment among AYAs.

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Section: Discussionmentioning

confidence: 99%

Cancer Incidence and Survival among Adolescents and Young Adults in Korea

Moon

Park

et al. 2014

PLoS ONE

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“…Cancer in adolescents represents a transition between the non-epithelial types common during childhood and the epithelial types that account for most cancers in adults [1][2][3][4]14]. Compared to younger or older patients, adolescents may be referred to pediatric or adult oncologists depending on referral physician and/or center of treatment policy.…”

Section: Discussionmentioning

confidence: 99%

“…Teenagers from 15 to 19 do not only have a higher overall incidence of malignancy than children, but also a different disease distribution to children and adults [1][2][3][4]. Unlike younger or older patients, adolescents may be referred by pediatricians/general physicians to either pediatric or adult oncologists.…”

Section: Introductionmentioning

confidence: 99%

Cancer in children and adolescents in Spain: incidence, treatment setting and provider specialty

et al. 2015

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This is the first population-based epidemiological study carried out in Spain on children and adolescents with cancer. Centralization of care to a small number of specialized centers and thorough pediatric and oncology team collaboration are needed to improve care and survival for adolescents with cancer in our country. We suggest the creation of specific adolescent tumor boards in main tertiary care hospitals, in which adolescents with cancer can benefit from the shared expertise of medical and pediatric specialists.

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“…Adolesan ve genç erişkin dönemde (15-39 yaş araşı) gö-rülen kanserler göreceli olarak daha iyi prognozludurlar (1). Günümüzde, erken tanı ve gelişmiş tedavi yöntem-lerleri sonucunda adolesan ve genç erişkin dönemde kanser tedavisi gören hastaların uzun dönem sağkalım oranları %75'lere kadar ulaşmıştır (2).…”

Section: Introductionunclassified

Pregnancy in cancer survivors; experience of a single tertiary center

Davutoğlu¹,

Özel²,

Madazli³

2017

İstanbul Tıp Fakültesi Dergisi

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ÖZETAmaç: Genç adolesan ve yetişkin dönemde kanser tedavisi gören kadınların gebeliklerini analiz edip obstetrik ve neonatal sonuçlarını değerlendirmektir. Gereç ve Yöntem: Cerrahpaşa Tıp Fakültesi Kadın Hastalıkları ve Doğum Kliniği'nde Ocak 2000-Aralık 2015 yılları arasında antenatal izlemi yapılan, adolesan ve genç erişkin dönemde kanser tedavisi görmüş ve izlem sürecinde gebe kalan 68 olgunun maternal ve perinatal sonuçları, retrospektif olarak değerlendirildi. Kanser tiplerinin dağılımı, kanser tanısının konulduğu yaş, uygulanan tedavi ve izlem süresi irdelendi. Maternal sonuçlar; doğum haftası, doğum kilosu ve perinatal sonuçlar değerlendirildi. Bulgular: En sık karşılaşılan kanserler, tiroid kanseri (%26,5), hematolojik maligniteler (%22,5) ve genital kanserler (%18) olarak saptandı. Olguların ortalama yaşı 31,7±5,5 ve nulliparite oranı %48,5 olarak saptandı. Ortalama doğum haftası 37,5±2,5; ortalama doğum kilosu 3020±717, 37 hafta öncesinde doğum oranı %12,1 iken 34 hafta öncesinde doğum oranı %8,8 olarak tespit edildi. Grubumuzda sezaryen, fetal gelişim kısıtlılığı, preeklampsi ve gestasyonel diayabet oranları sırasıyla %77,2, %5,8, %2,9 ve %8,8 olarak belirlendi. 2 hastada abortus izlenirken, 3 hastaya tıbbi nedenli tahliye yapıldı. Kansere yakalanma yaş ortalaması en düşük hematolojik kanserlerde gözlenirken (22,5±6,6) sonrasında iskelet sistemi (26±8,7) ve tiroid kanseri (26,9±5,6) yer aldı. Hastaların hiçbirinde konjenital fetal anomali izlenmedi. Sonuç: Kanser tedavisi sonrası gebe kalan hasta grubunda olumlu obstetrik sonuçlar gözlenmiş olup, bu hastaların gebelik izlemi, uygun merkezlerde, multidisipliner bir ekiple yapılmalıdır. Anahtar Kelimeler: Gebelik; kanser; kanserden sağ kalım; gebelik sonuçları ABSTRACT Objective: To investigate obstetric and perinatal outcomes among pregnant female survivors of adolescent and young adult cancers. Materials and Methods: A retrospective analysis of maternal and perinatal outcomes of 68 pregnant women with a history of cancer who received antenatal care at the Cerrahpasa Medical Faculty Obstetric and Gynecology Department between January 2000 and December 2015 was carried out. Perinatal and maternal outcomes were evaluated according to cancer type, timing of cancer diagnosis, and treatment modality. The distribution of cancer types, the age at which the cancer was diagnosed, the treatment modalities, and the duration of follow-up were analyzed. Maternal and perinatal outcomes were evaluated. Results: The most frequently encountered tumor types in pregnant women with a history of cancer were thyroid cancers (26.5%), hematologic malignancies (22.5%), and genital cancers (18%). The mean maternal age was 31.7±5.5 years, and the frequency of nulliparity was 48.5%. The mean gestational age at delivery was 37.5±2.5 weeks, the mean birth weight was KLİNİK ARAŞTIRMA/ CLINICAL RESEARCH

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Adolescents, young adults, and cancer—the international challenge

Cited by 55 publications

References 39 publications

Cancer Incidence and Survival among Adolescents and Young Adults in Korea

Cancer Incidence and Survival among Adolescents and Young Adults in Korea

Cancer in children and adolescents in Spain: incidence, treatment setting and provider specialty

Pregnancy in cancer survivors; experience of a single tertiary center

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