Satellite-derived high-resolution soil moisture and precipitation data have become widely adopted in natural hazard and climate change research. Landslide susceptibility mapping, which often relies on static predisposing factors, faces challenges in accounting for temporal changes, limiting its efficacy in accurately identifying potential locations for landslide occurrences. A key challenge is the lack of sufficient ground-based monitoring networks for soil moisture and precipitation, especially in remote areas with limited access to rain gauge data. This study addresses these limitations by integrating static landslide conditioning factors—such as topography, geology, and landscape features—with high-resolution dynamic satellite data, including soil moisture and precipitation. Using machine learning techniques, particularly the random forest (RF) algorithm, the approach enables the generation of dynamic landslide susceptibility maps that incorporate both spatial and temporal variations. To validate the proposed method, two significant rainfall events that occurred in Italy in October and November 2019—each triggering more than 40 landslides—were analyzed. High-resolution satellite rainfall and soil moisture data were integrated with statistical conditioning factors to identify high-probability landslide areas successfully. A differential susceptibility map was generated for these events to compare the results between them, illustrating how susceptibility variations within the study area are influenced by hydrological factors. The distinct susceptibility patterns associated with different hydrological conditions were accurately captured. It is suggested that future research focus on leveraging time-series high-resolution satellite data to enhance landslide susceptibility assessments further.