Adoption of a Newly Introduced Dermal Matrix: Preliminary Experience and Future Directions

Lisa, Andrea; Galtelli, Leonardo; Vinci, Valeriano; Veronesi, Alessandra; Cozzaglio, Luca; Cananzi, Ferdinando Carlo Maria; Sicoli, Federico; Klinger, Marco

doi:10.1155/2020/3261318

Cited by 9 publications

(9 citation statements)

References 12 publications

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“…However, ADM also has advantages in the treatment of chronic vascular ulcers and can improve the healing rate and wound closure rate [ 23 ]. Pelanc, a double-layer structure of ADM, is generally used as a pretreatment for skin grafting, can improve the survival rate of skin grafting and accelerate wound healing [ 24 ]. We treated a case of hand trauma with a skin defect on the palm.…”

Section: Discussionmentioning

confidence: 99%

Acellular dermal matrix for one-stage treatment of lower extremity full-thickness skin defect: a case series

Shen

Zhou

et al. 2023

BMC Surg

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Background Self-repair of lower limb wounds has always been one of the research hotspots. Flaps and skin graft are the preferred treatment for lower extremity wound reconstruction. However, these treatments have many disadvantages, such as secondary damage, poor healing quality. In recent years, the use of acellular dermal matrix has emerged as an alternative treatment option for extremity ulcers. Methods This study aimed to explore whether acellular dermal matrix can be used as a single treatment to promote wound healing. 7 patients with lower extremities cutaneous deficiency exposing bone or tendon, were covered by Pelnac, which was an acellular dermal matrix product approved by China Food and Drug Administration. All the wound was treated by Pelnac without flaps and skin graft. The external dressing was changed every 10 days. Results After a maximum of 20 weeks, all the wounds were completely healed. During the 12 months follow-up period none of the patients developed skin wear on the treatment area. All patients maintained their postoperative ambulatory ability. All patients were satisfied with the appearance and feeling after wound healing. Conclusion These findings may mean acellular dermal matrix is a novel method offering opportunity for treatment of lower extremities cutaneous deficiency exposing bone or tendon. It also has the potential to close wounds of all uninfected, non-ischemic, full-thickness cutaneous deficiency.

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Section: Discussionmentioning

confidence: 99%

Acellular dermal matrix for one-stage treatment of lower extremity full-thickness skin defect: a case series

Shen

Zhou

et al. 2023

BMC Surg

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“…A handful of studies indicate regeneration of full-thickness skin defects using ADM, and without skin graft or ap surgery (19)(20)(21). PELNAC, a doublelayer structure of ADM, is generally used as a pretreatment before skin grafting, which can improve the survival rate of skin grafting and accelerate the wound healing (22). We once treated a case of hand trauma with a skin defect on the palm.…”

Section: Discussionmentioning

confidence: 99%

Acellular dermal matrix treats lower extremity full-thickness skin defect on one-stage without skin graft or flaps

Shen²,

Zhou

et al. 2022

Preprint

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Background: Self-repair of lower limb wounds has always been one of the research hotspots. Flaps and skin graft are the preferred treatment for lower extremity wound reconstruction. However, these treatments have many disadvantages, such as secondary damage, poor healing quality. In recent years, the use of acellular dermal matrix has emerged as an alternative treatment option for extremity ulcers. Methods: This study aimed to explore whether acellular dermal matrix can be used as a single treatment to promote wound healing. 7 patients with lower extremities cutaneous deficiency exposing bone or tendon, was covered by Pelnac, which was an acellular dermal matrix product approved by China Food and Drug Administration. All the wound was treated by Pelnac without flaps and skin graft. The external dressing was changed every 10 days. Results: After a maximum of 20 weeks, all the wounds were completely healed. During the 12 months follow-up period none of the patients developed skin wear on the treatment area. All patients maintained their postoperative ambulatory ability. All patients were satisfied with the appearance and feeling after wound healing. Conclusion: These findings may mean acellular dermal matrix is a novel method oﬀering opportunity for treatment of lower extremities cutaneous deficiency exposing bone or tendon. It also has the potential to close wounds of all uninfected, non-ischemic, full-thickness cutaneous deficiency.

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“…It does, however, have drawbacks (for example, infection) (93). ADM has so been the subject of investigations to replace the mesh in these operations (Figure 1D) (1,2,21,29,30,33,36,68,(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91)(94)(95)(96)(97)(98)(99)(100)(101).…”

Section: Chestmentioning

confidence: 99%

Acellular dermal matrix in reconstructive surgery: Applications, benefits, and cost

Mohammadyari

Parvin²,

Khorvash³

et al. 2023

Front. Transplant.

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Modern tissue engineering has made substantial advancements that have revolutionized plastic surgery. Acellular dermal matrix (ADM) is an example that has gained considerable attention recently. ADM can be made from humans, bovines, or porcine tissues. ADM acts as a scaffold that incorporates into the recipient tissue. It is gradually infiltrated by fibroblasts and vascularized. Fortunately, many techniques have been used to remove cellular and antigenic components from ADM to minimize immune system rejection. ADM is made of collagen, fibronectin, elastin, laminin, glycosaminoglycans, and hyaluronic acid. It is used in critical wounds (e.g., diabetic wounds) to protect soft tissue and accelerate wound healing. It is also used in implant-based breast reconstruction surgery to improve aesthetic outcomes and reduce capsule contracture risk. ADM has also gained attention in abdominal and chest wall defects. Some studies have shown that ADM is associated with less erosion and infection in abdominal hernias than synthetic meshes. However, its higher cost prevents it from being commonly used in hernia repair. Also, using ADM in tendon repair (e.g., Achilles tendon) has been associated with increased stability and reduced rejection rate. Despite its advantages, ADM might result in complications such as hematoma, seroma, necrosis, and infection. Moreover, ADM is expensive, making it an unsuitable option for many patients. Finally, the literature on ADM is insufficient, and more research on the results of ADM usage in surgeries is needed. This article aims to review the literature regarding the application, Benefits, and costs of ADM in reconstructive surgery.

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Adoption of a Newly Introduced Dermal Matrix: Preliminary Experience and Future Directions

Cited by 9 publications

References 12 publications

Acellular dermal matrix for one-stage treatment of lower extremity full-thickness skin defect: a case series

Acellular dermal matrix for one-stage treatment of lower extremity full-thickness skin defect: a case series

Acellular dermal matrix treats lower extremity full-thickness skin defect on one-stage without skin graft or flaps

Acellular dermal matrix in reconstructive surgery: Applications, benefits, and cost

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