This chapter examines the essential association of integrity, ethics, and security in the integration of quantum computing in supply chain operations. Commencing with an investigation of security risks and ethical frameworks explicitly in quantum supply chains, the discussion navigates through significant considerations like transparency in data management, data privacy, regulatory compliance, and fairness. The chapter also addresses the ethical dilemmas and security challenges posed by quantum-enabled supply chain management with the blend of theoretical analysis and practical insights. Gradually, more businesses are adopting quantum technologies to optimize their supply chains, and safeguarding security and integrity becomes important. Stakeholders can foster trust, resilience, and transparency in quantum-enabled supply chain operations by proactively solving ethical concerns and instigating vigorous security measures.