Adoption Study Demonstrating Two Genetic Pathways to Drug Abuse

Cadoret, Remi J.; Yates, William R.; Troughton, Ed; Woodworth, George; Stewart, Mark A.

doi:10.1001/archpsyc.1995.03950130042005

Cited by 315 publications

(186 citation statements)

References 29 publications

Supporting

Mentioning

166

Contrasting

Unclassified

Order By: Relevance

“…In a sample of male and female adoptees combined (Cadoret et al, 1986), and a sample of male adoptees only (Cadoret et al, 1995), evidence of a direct as well as a indirect genetic pathway to drug abuse was reported. However, in a sample of female adoptees only , support for only the indirect path was found, suggesting the possibility of gender-specific biological influences.…”

Section: Gender Differencesmentioning

confidence: 99%

“…Cadoret and co-workers (Cadoret et al, 1986(Cadoret et al, , 1995 have reported evidence of two genetic pathways to drug abuse: a direct path leading from alcohol abuse or dependence in the biological parent to drug abuse in the adoptee, and an indirect path from antisocial behavior in biologic relatives to antisocial behavior in adoptee to adoptee drug abuse.…”

Section: Relation To Other Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Genetic and environmental influences on drug use and abuse/dependence in male and female twins

Bree

Johnson²,

Neale

et al. 1998

Drug and Alcohol Dependence

214

129

View full text Add to dashboard Cite

Twins were recruited through alcohol and drug treatment programs. With structural equation modeling, genetic and environmental estimates were obtained for use and DSM-III abuse/dependence of sedatives, opioids, cocaine, stimulants, and cannabis as well as any illicit drug. Analyses were conducted separately for males and females. Models included thresholds based on population prevalence of use or abuse/dependence and ever having been in treatment. Genetic influences were found for most measures. They were generally stronger for males than females and for clinical diagnoses of abuse/dependence compared to use. Common environmental influences played a greater role in use than abuse/dependence.

show abstract

Section: Gender Differencesmentioning

confidence: 99%

Section: Relation To Other Studiesmentioning

confidence: 99%

Genetic and environmental influences on drug use and abuse/dependence in male and female twins

Bree

Johnson²,

Neale

et al. 1998

Drug and Alcohol Dependence

214

129

View full text Add to dashboard Cite

show abstract

“…Family influences on children's early alcohol and drug use range from biological transmission of vulnerability to ineffective parenting. Although some evidence of direct heritable linkages exists for substance use [22][23][24][25], the link is more tenuous than that for related conduct disorder and antisocial behavior [26]. Regardless of heritable predispositions for problem behaviors, family contexts serve to buffer or to incubate their expression [27][28][29].…”

Section: Maternal Psychopathology and Child Outcomesmentioning

confidence: 99%

Prevalence and Comorbidity of Mental Disorders among American Indian Children in the Northern Midwest

Whitbeck

Johnson

Hoyt

et al. 2006

Journal of Adolescent Health

View full text Add to dashboard Cite

“…Adoption studies suggest that some of the familial patterns are genetically mediated. Individuals adopted from substance-abusing parents are more likely to become substance abusers than the others raised in identical environmentals (Cadoret et al 1986(Cadoret et al , 1995.…”

Section: Genetic Contributions To Human Substance Abuse Vulnerabilitymentioning

confidence: 99%

Molecular Genetics of Substance Abuse Vulnerability A Current Approach

Uhl

1999

Neuropsychopharmacology

View full text Add to dashboard Cite

Which genes contribute to drug abuse vulnerability? How do vulnerability-enhancing alleles work? How are the effects of a specific allelic influenced by other genes and the environment? Identifying the specific gene loci at which allelic variants contribute to human vulnerability to substance abuse is a major goal of the developing field of drug abuse molecular genetics. This work is likely to play an increasingly prominent role in drug abuse research. The feasibility of specific approaches to this problem is now increasingly supported by convergent information from family, twin, and adoption studies of families of drug abusers (see Table 1 for some terms). Results of mouse genetic studies add to our confidence that drug abuse vulnerability genes can be identified. Elucidation of increasingly lengthy lists of candidate genes and rapid development of improving methodologies for approaching complex genetic disorders both enhance the plausibility of identifying such gene variants. The benefits of finding drug abuse vulnerability gene variants are also increasingly appreciated by workers frustrated by our current inability to target prevention and treatment efforts effectively to those whose genetic predispositions leave them most likely to benefit. This review presents a current perspective on the status of approaches to identifying substance abuse vulnerability genes. It reflects material reviewed in two recent meetings as well as background information covered in recent reviews (Uhl et

show abstract

Adoption Study Demonstrating Two Genetic Pathways to Drug Abuse

Abstract: This study confirms the model of two independent genetic factors involved in drug abuse/dependence and previous findings that disturbed adoptive parents are associated with adoptee drug abuse/dependency.

Cited by 315 publications

References 29 publications

Genetic and environmental influences on drug use and abuse/dependence in male and female twins

Genetic and environmental influences on drug use and abuse/dependence in male and female twins

Prevalence and Comorbidity of Mental Disorders among American Indian Children in the Northern Midwest

Molecular Genetics of Substance Abuse Vulnerability A Current Approach

Contact Info

Product

Resources

About