Adoptive T Cell Therapy Targeting CD1 and MR1

Guo, Tingxi; Chamoto, Kenji; Hirano, Naoto

doi:10.3389/fimmu.2015.00247

Cited by 16 publications

(12 citation statements)

References 99 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, they recognized hCD1d that presented the same lipids with significantly more ligand selectivity. These data support the potential use of hCD1d-lipid specific immunotherapy using mouse iNKT TCRs [ 27 ].…”

Section: Introductionsupporting

confidence: 76%

See 1 more Smart Citation

Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors

et al. 2016

Self Cite

View full text Add to dashboard Cite

Invariant natural killer T (iNKT) cells recognize self-lipids presented by CD1d through characteristic TCRs, which mainly consist of the invariant Vα14-Jα18 TCRα chain and Vβ8.2, 7 or 2 TCRβ chains with hypervariable CDR3β sequences in mice. The iNKT cell-CD1d axis is conserved between humans and mice, and human CD1d reactivity of murine iNKT cells have been described. However, the detailed differences between the recognition of human and mouse CD1d bound to various self-lipids by mouse iNKT TCRs are largely unknown. In this study, we generated a de novo murine iNKT TCR repertoire with a wider range of autoreactivity compared with that of naturally occurring peripheral iNKT TCRs. Vβ8.2 mouse iNKT TCRs capable of recognizing the human CD1d-self-lipid tetramer were identified, although such clones were not detectable in the Vβ7 or Vβ2 iNKT TCR repertoire. In line with previously reports, clonotypic Vβ8.2 iNKT TCRs with unique CDR3β loops did not discriminate among lipids presented by mouse CD1d. Unexpectedly, however, these iNKT TCRs showed greater ligand selectivity toward human CD1d presenting the same lipids. Our findings demonstrated that the recognition of mouse and human CD1d-self-lipid complexes by murine iNKT TCRs is not conserved, thereby further elucidating the differences between cognate and cross-species reactivity of self-antigens by mouse iNKT TCRs.

show abstract

Section: Introductionsupporting

confidence: 76%

“…Given the recent clinical success of adoptive T cell therapy in cancer, CD1d may be a novel target for overcoming the limitation of HLA restriction and the broadening of the application of this therapy [ 27 ]. Currently, HLA-restricted tumor-specific TCRs are transduced into autologous T cells, which are reinfused into the patient.…”

Section: Discussionmentioning

confidence: 99%

Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…Given their ability to rapidly produce cytokines after stimulation, direct lysing of microbe-infected cells, and their potential to regulate immune responses, MAIT cells similar to iNKT cells and Vγ9Vδ2 T cells, which have been used as targets in immunotherapy research ( 96 – 101 ), may also be an effective target for disease treatment. For example, due to their potential role in cancers and infectious diseases, adoptive MAIT cell transfer therapy may be a promising approach to treat diseases ( 102 ). Moreover, with a growing number of MAIT cell antigens to be found, the potent antigens can be administered alone or pulsed on APCs to enhance immune responses, or can be used as an effective adjuvant to boost vaccine efficacy.…”

Section: Mait Cells and Diseasesmentioning

confidence: 99%

Mucosal-Associated Invariant T Cells: New Insights into Antigen Recognition and Activation

Xiao

Cai

2017

Front. Immunol.

View full text Add to dashboard Cite

Mucosal-associated invariant T (MAIT) cells, a novel subpopulation of innate-like T cells that express an invariant T cell receptor (TCR)α chain and a diverse TCRβ chain, can recognize a distinct set of small molecules, vitamin B metabolites, derived from some bacteria, fungi but not viruses, in the context of an evolutionarily conserved major histocompatibility complex-related molecule 1 (MR1). This implies that MAIT cells may play unique and important roles in host immunity. Although viral antigens are not recognized by this limited TCR repertoire, MAIT cells are known to be activated in a TCR-independent mechanism during some viral infections, such as hepatitis C virus and influenza virus. In this article, we will review recent works in MAIT cell antigen recognition, activation and the role MAIT cells may play in the process of bacterial and viral infections and pathogenesis of non-infectious diseases.

show abstract

“…However, a recent study documented the presence of α-anomeric glycosylceramides including α-GalCer, in minute quantities, within mammalian cells, which could serve as endogenous i NKT cell Ags ( 18 ). α-GalCer has been utilized as a powerful experimental tool in many mouse studies and as a therapeutic agent in several clinical trials for cancer and viral diseases ( 19 , 20 ).…”

mentioning

confidence: 99%