ADP‐induced platelet aggregation in the microcirculation of pig myocardium and rabbit kidneys

Jørgensen, Leif

doi:10.1111/j.1538-7836.2005.01057.x

Cited by 20 publications

(9 citation statements)

References 22 publications

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“…The theory that platelet stimulation may lead to intimal injury is supported by another series of publications, recently summarized as an Historical Sketch in this Journal [47]. We were able to show that ADP stimulated platelets in rabbits and pigs may cause endothelial injury and vasculitis.…”

Section: Discussionsupporting

confidence: 55%

The role of platelets in the initial stages of atherosclerosis

Jørgensen

2006

Journal of Thrombosis and Haemostasis

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Section: Discussionsupporting

confidence: 55%

The role of platelets in the initial stages of atherosclerosis

Jørgensen

2006

Journal of Thrombosis and Haemostasis

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“…Abundant evidence published from the 1960s and onwards supports the essential role of platelets in the initial stages of atherosclerosis, as recently reviewed [1,2]. Governed by disturbed flow, platelets adhere to the arterial wall in vivo , even in the absence of endothelial cell denudation, initiating lesion formation [3–6]. In hypercholesteremic rabbits, platelets adhere to sites with a predilection for atherosclerosis before lesions are detectable [5].…”

Section: Platelets In Atherosclerosismentioning

confidence: 99%

Platelets modulate atherogenesis and progression of atherosclerotic plaques via interaction with progenitor and dendritic cells

Gawaz¹,

Stellos²,

Langer³

2008

Journal of Thrombosis and Haemostasis

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“…In fact, platelet aggregates have been found as microemboli in downstream epicardial and intramyocardial arteries in cases of sudden coronary death [39–41]. Experimentally, embolism with platelet aggregates in the myocardial microcirculation may alone cause infarction [30, 42].…”

Section: Discussionmentioning

confidence: 99%

Frequency of acute asymptomatic myocardial infarction and an estimate of infarct age in cases of abrupt sudden death observed in a forensic autopsy material

Mortensen

Rognum

Straume

et al. 2008

J Cellular Molecular Medi

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The aim of this study is to determine the frequency of acute infarcts at autopsy in cases of unexpected abrupt deaths in persons with coronary heart disease. In addition, we want to estimate the time between onset of infarct and death based on evolving tissue changes in the infarct known to occur during the first hours. Thirty cases of unexpected, abrupt deaths were selected from a forensic autopsy material. Half of them had a preliminary diagnosis of coronary heart disease, the other half a preliminary diagnosis not involving the heart or chest area. Complete autopsies were performed. The myocardium and the coronary arteries were sampled and examined without knowledge of the gross findings or to which group the case belonged. Myocardial infarcts and acute coronary changes were found in both groups, less frequently in the non-coronary group. The age of the myocardial and coronary lesions was estimated by observing morphological characteristics changing with time, e.g. increasing polymorphonuclear leucocytes in the infarcted myocardium, and increasing amount of fibrin in thrombi. The majority of cases in the coronary group died with an extensive asymptomatic myocardial infarction, which probably had lasted 5–6 hrs or less. Acute changes in the right coronary artery and its area of supply prevailed. Acute myocardial infarcts were observed also in a minority of the non-coronary group, but myocardial infarction was not the cause of death in any of them. Abrupt coronary death is most often preceded by an extensive asymptomatic myocardial infarction within the last 5–6 hrs.

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ADP‐induced platelet aggregation in the microcirculation of pig myocardium and rabbit kidneys

Cited by 20 publications

References 22 publications

The role of platelets in the initial stages of atherosclerosis

The role of platelets in the initial stages of atherosclerosis

Platelets modulate atherogenesis and progression of atherosclerotic plaques via interaction with progenitor and dendritic cells

Frequency of acute asymptomatic myocardial infarction and an estimate of infarct age in cases of abrupt sudden death observed in a forensic autopsy material

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