2023
DOI: 10.1002/jobm.202200692
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AdpAlin regulates lincomycin and melanin biosynthesis by modulating precursors flux in Streptomyces lincolnensis

Abstract: Lincomycin is one of the most important antibiotics. However, transcriptional regulation network of secondary metabolism in Streptomyces lincolnensis, the lincomycin producer, remained obscure. AdpA from S. lincolnensis (namely AdpAlin) has been proved to activate lincomycin biosynthesis. Here we found that both lincomycin and melanin took l‐tyrosine as precursor, and AdpAlin activated melanin biosynthesis as well. Three tyrosinases, MelC2, MelD2, and MelE, and one tyrosine peroxygenase, LmbB2, participated in… Show more

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Cited by 6 publications
(2 citation statements)
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“…Both lincomycin and melanin use l-tyrosine as precursor, and the regulator AdpA lin in S. lincolnensis is a pleiotropic transcriptional regulator. It regulates lincomycin precursor flux and melanin biosynthesis during biosynthesis through direct activation of melC , melE and lmbB1/lmbB2 or inhibition of melD [ 27 ].…”
Section: Effect Of Precursors On Antibiotic Biosynthesismentioning
confidence: 99%
See 1 more Smart Citation
“…Both lincomycin and melanin use l-tyrosine as precursor, and the regulator AdpA lin in S. lincolnensis is a pleiotropic transcriptional regulator. It regulates lincomycin precursor flux and melanin biosynthesis during biosynthesis through direct activation of melC , melE and lmbB1/lmbB2 or inhibition of melD [ 27 ].…”
Section: Effect Of Precursors On Antibiotic Biosynthesismentioning
confidence: 99%
“…Both lincomycin and melanin use l-tyrosine as precursor, and the regulator AdpAlin in S. lincolnensis is a pleiotropic transcriptional regulator. It regulates lincomycin precursor flux and melanin biosynthesis during biosynthesis through direct activation of melC, melE and lmbB1/lmbB2 or inhibition of melD [27]. In addition to increasing precursor supply directly, it is also possible to increase precursor content and utilization indirectly by manipulating precursor synthesis genes.…”
Section: Improved Precursor Supply Can Partially Relieve the Limitati...mentioning
confidence: 99%