Adrenal antibiotics detect asymptomatic auto-immune adrenal insufficiency in young women with premature ovarian failure

Merz, Susanne

doi:10.1093/humrep/deg195

Cited by 1 publication

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“…These changes may lead to increased risk of osteoporosis, emotional issues or cardiovascular diseases; ~1% of woman worldwide are affected by POI, and etiological and pathophysiological mechanisms underlying its development have yet not been fully known [ 5 , 6 ]. Genetic [ 7 , 8 ], immunological [ 9 ], and environmental factors [ 10 , 11 ] have significant impact on POI development. In clinical applications, some interventions such as hormonal replacement therapy (using 17-β estradiol and dydrogesterone) [ 12 , 13 ] and traditional Chinese medicine [ 14 ] are intended to relieve endocrine disturbance or restore ovarian function; however, the effectiveness of these measures is limited.…”

Section: Introductionmentioning

confidence: 99%

Human Menstrual Blood-Derived Stromal Cells Promote Recovery of Premature Ovarian Insufficiency Via Regulating the ECM-Dependent FAK/AKT Signaling

Feng

Tan

2018

Stem Cell Rev and Rep

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POI is characterized by “absent not abnormal” menstruation with hormonal disorders in woman younger than 40 years of age, and etiological and pathophysiological mechanisms underlying the POI development have not been clearly defined. Recently, due to advantages such as abundant sources and non-invasive methods of harvest, MenSCs have been emerging as a promising treatment strategy for the recovery of female reproductive damage. Here, we demonstrated that MenSCs graft in POI mice after CTX treatment could restore ovarian function by regulating normal follicle development and estrous cycle, reducing apoptosis in ovaries to maintain homeostasis of microenvironment and modulating serum sex hormones to a relatively normal status. Moreover, MenSCs participated in the activation of ovarian transcriptional expression in ECM-dependent FAK/AKT signaling pathway and thus restored ovarian function to a certain extent. MenSCs transplantation was proved to be an effective way to repair ovarian function with low immunogenicity, suggesting its great potential for POI treatment. Electronic supplementary material The online version of this article (10.1007/s12015-018-9867-0) contains supplementary material, which is available to authorized users.

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