Adrenal Castleman Disease on 99mTc-HYNIC-TOC Scan and FDG PET/CT

Abstract

Adrenal Castleman disease is very rare. We reported image findings of a right adrenal mass in a 75-year-old man on 99mTc-HYNIC-TOC scan and FDG PET/CT. There was obviously elevated 99mTc-HYNIC-TOC activity, but the intensity of FDG activity was remarkable. Pheochromocytoma was initially suspected. However, pathology from resected specimen showed adrenal Castleman disease.

68Ga-DOTATATE and 68Ga-Pentixafor PET/CT in a Patient with Castleman Disease of the Retroperitoneum

“…Castleman disease (CD) is a heterogeneous lymphoproliferative disease [1]. The key to its treatment lies in the evaluation of the systemic condition, but because of its varying locations and clinical manifestations, diagnosis can be quite challenging [2][3][4][5]. Thus, effective diagnostic methods are needed [6].…”

Colonic Castleman Disease on FDG PET/CT

“…It mainly involves lymph node 3 . It also occurs in the kidney, 4,5 adrenal, 6 lung, 7 pancreas, 8 and liver 9 . On PET/CT image, Castleman disease can be misdiagnosed as malignant tumor, presenting as intense FDG uptake 4,8 .…”

Hypermetabolic Unicentric Castleman Disease of Kidney on FDG PET/CT

“…Rarely, unicentric Castleman disease presents in unusual sites, including the lung, pancreas, liver, adrenal, orbits, nasopharynx, spleen, parotid gland, and small bowel. [2][3][4][5][6][7][8][9][10] It has no specific clinical or radiologic features. Histologic examination is the key to a correct diagnosis.…”

“…It is characterized by involvement of a single lymph node region. Rarely, unicentric Castleman disease presents in unusual sites, including the lung, pancreas, liver, adrenal, orbits, nasopharynx, spleen, parotid gland, and small bowel [2][3][4][5][6][7][8][9][10]. It has no specific clinical or radiologic features.…”