Adrenal Cortex

Labhart, A.

doi:10.1007/978-3-642-70509-0_7

Cited by 4 publications

(1 citation statement)

References 804 publications

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“…However, the patients are still capable of leading a normal life without maintenance therapy. They may feel healthy, and even the important symptom of fatigue may be absent or inconspicuous [21,22]. Adrenal insufficiency preceded by long-term autoantibody positivity could lead to a life-threatening event that sometimes represents the first clinical manifestation of Addison's disease [10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

Type 1 Diabetes and Addison’s Disease: When the Diagnosis Is Suggested by the Continuous Glucose Monitoring System

et al. 2021

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Our objective is to emphasize the important role of continuous glucose monitoring (CGM) in suggesting adrenal insufficiency in patients affected by type 1 diabetes. We describe an adolescent girl with type 1 diabetes and subsequent latent Addison’s disease diagnosed based on a recurrent hypoglycemic trend detected by CGM. In patients with type 1 diabetes, persistent unexplained hypoglycemic episodes at dawn together with reduced insulin requirement arouse souspicionof adrenal insufficiency. Adrenal insufficiency secondary to autoimmune Addison’s disease, even if rarely encountered among young patients, may be initially symptomless and characterized by slow progression up to acute adrenal crisis, which represents a potentially life-threatening condition. Besides glycometabolic assessment and adequate insulin dosage adjustment, type 1 diabetes needs prompt recognition of potentially associated autoimmune conditions. Among these, Addison’s disease can be suspected, although latent or paucisymptomatic, through periodic and careful evaluation of CGM data.

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