Adrenal cortical function during the evolution of experimental dietetic cirrhosis in rats

Wahi, P. N.; Ramachandran, Sudarshan; Kehar, U

doi:10.1002/path.1700790121

Cited by 1 publication

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“…Diffuse and nodular hyperplasia of the AG are not only reparative processes as far as adrenocortical damages are concerned, but are significant func tionally, too.35,36) According to Sasano39,40), the AG is regarded to be the source of aldosterone production; its hyperplasia or adenoma is usually found in hyperaldo steronism. Increased urinary aldosterone excretion is generally observed in liver disease with a large amount of ascites,13, 16,33,46,50,52,53) This is explained by increased aldosterone secretion from the adrenal and/or reduced aldosterone inactivation in the injured liver. 8,9,16,46) This is supported also by the fact that adrenalectomyl8, 29) The observations on adrenal veins in various types of liver disease are interesting and significant.…”

Section: Discussionmentioning

confidence: 99%

The Adrenal Glands in Liver Disease

Demura¹

1962

Tohoku J. Exp. Med.

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Hyperestrinism in liver cirrhosis has been known to occur for many years.28) Concerning the source of aldosterone production in the adrenal cortex, Sasano39,40) regarded it the outer margin of the fasciculata and proposed the term, zona glomerulosa adulta. The results of the present investigation would also confirm his concept. It will be further taken into consideration, that adrenal lesions in liver diseases are induced not only by endocrine disturbance including stress,3) but also by certain other factors of topography of the organ, particularly direct effects of abnormal portal circulation. MATERIALS AND METHODS Both adrenals of 141 autopsy cases of liver diseases with minimum or slight post-mortem changes were selected for the examination. After Zenker-formol fixation, the tissues were embedded in paraffin, and sections were stained with hematoxyline and eosin, Goldner's trichrome combined with Weigert's elastica stain and Pap's silver impregnation. Frozen sections stained with scarlet red for the demonstration of lipid were also prepared. Well's spirochetes were demonstrated by Dieterle's silver impregnation. The pituitaries were also available in 61 of the cases and stained with PAS-methylbule-organe G, aldehyde fuchsin and performic alcian blue (Adams and Pearse1)). With the latter staining, basophil cells could be divided into two types, S and R, as the original authors observed.

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Section: Discussionmentioning

confidence: 99%

The Adrenal Glands in Liver Disease

Demura¹

1962

Tohoku J. Exp. Med.

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show abstract

Adrenal cortical function during the evolution of experimental dietetic cirrhosis in rats

Cited by 1 publication

References 13 publications

The Adrenal Glands in Liver Disease

The Adrenal Glands in Liver Disease

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