Adrenal cytomegaly

Aterman, K.; Kerenyi, N; Lee, Mary

doi:10.1007/bf00556313

Cited by 23 publications

(35 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These cells each had a very large, round, hyperchromatic nucleus and cytoplasm more eosinophilic than that of the transient cortex cells; they stood out because of their great size. Later, these cells were found elsewhere—in adult patients with congenital adrenal hypoplasia (10), in newborns with congenital anomalies (Beckwith-Wiedemann syndrome) (2 Beckwith, 1969), in newborns with Rh incompatibility (1) and, very rarely, in healthy adults (23). None of these patients had Cushing syndrome.…”

Section: Introductionmentioning

confidence: 99%

Massive Neonatal Adrenal Enlargement Due to Cytomegaly, Persistence of the Transient Cortex, and Hyperplasia of the Permanent Cortex

Carney

Kitsuda

et al. 2012

American Journal of Surgical Pathology

View full text Add to dashboard Cite

We describe massive enlargement of both adrenal glands in 3 newborns, 2 girls and 1 boy. Two had hemihypertrophy and other congenital abnormalities but no identified genetic mutation; the third had genetically proven Beckwith-Wiedemann syndrome. Two had severe Cushing syndrome, the third had hypercortisolemia but no clinical Cushing syndrome. Bilateral adrenalectomy cured Cushing syndrome in the 2 with the severe symptoms; total adrenal weight was 44 and 53 gm in the patients, respectively. Unilateral adrenalectomy was performed in the third patient: the gland weighed 52 g; postoperatively, the patient's hypercortisolemia normalized and, concomitantly, the enlarged contralateral adrenal gland had a 5-fold decrease in size to slight enlargement 6 years postoperatively. Microscopically, the 3 patients had similar pathology: massive adrenal enlargement due to a combination of cytomegaly, persistence of the transient cortex, and hyperplasia of the permanent cortex. The pathological findings were most likely the result of the genetic mutation identified in 1 patient and of an unknown mutation in the remaining 2 patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Massive Neonatal Adrenal Enlargement Due to Cytomegaly, Persistence of the Transient Cortex, and Hyperplasia of the Permanent Cortex

Carney

Kitsuda

et al. 2012

American Journal of Surgical Pathology

View full text Add to dashboard Cite

show abstract

“…Diese "echte" infektiöse Zytomegalie ist von einer "Pseudo-" oder "sogenannten" Zytomegalie zu unterscheiden, die in gut 5 % aller Sektionsfälle der Perinatalperiode gefunden wird [3] und durch das Auftreten einkerniger Riesenzellen mit bis 40 μm durchmessenden hyperchromatischen Kernen gekennzeichnet ist, welche vereinzelte Einschlüsse zu erkennen geben [3]. Diese sog.…”

Section: Hiv-infektionunclassified

Adrenalitis

Saeger

2016

Pathologe

View full text Add to dashboard Cite

Inflammation of the adrenal glands is caused by autoimmunopathies or infections and can induce adrenal insufficiency. Autoimmune lymphocytic adrenalitis is often combined with other autoimmune diseases and the most frequent cause of Addison's disease; however, it only becomes clinically apparent when more than 90 % of the adrenal cortex has been destroyed. Histological features are characterized by lymphoplasmacytic inflammation leading to an increased destruction of adrenocortical tissue but less severe courses can also occur. The second most frequent form of adrenalitis is adrenal tuberculosis, showing typical granulomatous findings that are nearly always caused by spreading from a tuberculous pulmonary focus. Other bacterial as well as viral infections, such as Epstein-Barr virus (EBV), cytomegalovirus (CMV) and others, generally affect the adrenal glands only in patients with immunodeficiency disorders. In these infections, the adrenal cortex and medulla are frequently involved to roughly the same extent. Although surgical specimens from inflammatory adrenal lesions are extremely rare, the various forms of adrenalitis play an important role in the post-mortem examination of the adrenal glands for clarification of unclear causes of death (e.g. death during an Addisonian crisis).

show abstract

“…Letters to the Editor Comment Adrenal cytomegaly has been described as a feature of Beckwith's syndrome as well as in isolation, generally as a totally unexpected finding, unrelated to race, maturity, or gross abnormality but possibly related to erythroblastosis fetalis or prenatal viral infection (Birdwell and Dimmette, 1967;Morison, 1970;Aterman et al, 1972;Potter and Craig, 1975). A theory that adrenal cytomegaly may be an indication of polyploidy occurring when the adrenal cortical cells are intensely stimulated was proposed by Aterman et al in 1972, who thought that that stimulus could be chronic stress.…”

Section: Microscopic Findingsmentioning

confidence: 99%