Adrenal Estrogens in Patients With Metastatic Breast Cancer

West, Charles D.; Damast, Barbara; Pearson, O H

doi:10.1097/00006254-195813000-00024

Cited by 2 publications

(3 citation statements)

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“…In addition, the mono-and di-acetates were prepared by treating some of the eluate with a mixture of acetic anhydride and pyridine (1 : 50) for 15 hr at 25°C [Gorski & Erb, 1959], and these were run on a chromatogram in system (1), together with the mono-and di-acetates of authentic oestradiol-17/3 which had been prepared in the same way. After chromatography, the acetates were hydrolysed on the paper by treatment with dioxane and HC1 vapour [West, Damast & Pearson, 1958], and detected by the use of Folin and Ciocalteu's reagent. The RF values of the two acetates were identical with those of the monoand di-acetates of oestradiol-17/3.…”

Section: Resultsmentioning

confidence: 99%

Steroids Present in the Follicular Fluid of the Mare

Short¹

1960

Journal of Endocrinology

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Using paper chromatographic techniques, it has been possible to identify the following steroids in the follicular fluid of the mare (results expressed as \g=m\g/1.):oestradiol-17\g=b\,460\g=m\g;oestrone, 34 \g=m\g;cortisol, 12 \g=m\g;progesterone, 124 \g=m\g; 17\g=a\-hydroxyprogesterone, 66 \g=m\g;epitestosterone, 24 \g=m\g;androstenedione, 136 \g=m\g. In addition to these seven compounds, 136 \ g=m\ g of an unidentified oestrogen-like substance and 52 \ g=m\ g of an unidentified 17-ketosteroid were also present. This is the first time that epitestosterone has been identified as a natural product, and the possible significance of this compound is discussed. 19-Hydroxyandrostenedione, the postulated intermediate in the formation of oestrone from androstenedione, was not detected in this study, and some doubt is therefore cast on the theory that it is an essential intermediate in the biosynthesis of the ovarian oestrogens.The presence of relatively large amounts of an unidentified polar oestrogen in follicular fluid suggests that it may be of some physiological significance, although at the present time no information is available on the biological activity of this compound.

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Section: Resultsmentioning

confidence: 99%

Steroids Present in the Follicular Fluid of the Mare

Short¹

1960

Journal of Endocrinology

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“…Hershel Sandberg and co‐workers (4) induced increased excretion of estrogen in ovariectomized but otherwise normal women, by the administration of ACTH. West, Damast and Pearson (5) observed similar increases in estrogen excretion in patients with mammary carcinoma who received ACTH.…”

mentioning

confidence: 77%

“…The ovary and the adrenal cortex are the only known sources of estrogen production in the nonpregnant woman (3, 5). Among other sources which might be considered, diet would seem the only one worthy of consideration.…”

Section: Discussionmentioning

confidence: 99%

Function of the Postmenopausal Ovary. Comparison of Urinary Estrogen and Gonadotropin Excretion and Response to Administration of FSH in Postmenopausal and Ovariectomized Women††

Paulsen

Leach

Sandberg

et al. 1958

J American Geriatrics Society

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After the menopause, reproductive capacity is lost, but there is evidence that estrogen production is continued. For example, estrogens can be extracted from the urine of postmenopausal women, evidence of estrogenic activity not infrequently can be seen in endometrial biopsy specimens, and vaginal smear examinations may show changes suggestive of estrogen effect. The origin of this estrogen, however, is not entirely clear. Heller, Farney and Myers (1), observing the abrupt increase of climacteric symptoms after the removal of postmenopausal ovaries, suggested that the ovary was the most important site of postmenopausal estrogen production. Hertig (2), studying the histologic structure of aging ovaries, concluded that the stromal cells may assume secretory function.There is considerable evidence that the adrenal cortex is a source of estrogen production. Dao (3) recovered estrogens from the urine of ovariectomized patients having carcinoma of the breast. Hershel Sandberg and co-workers (4) induced increased excretion of estrogen in ovariectomized but otherwise normal women, by the administration of ACTH. West, Damast and Pearson (5) observed similar increases in estrogen excretion in patients with mammary carcinoma who received AOTH.It is the purpose of this report to present studies in which postmenopausal ovarian function was evaluated in the following manner:1. The urinary estrogen and gonadotropin excretion of 51 normal postmenopausal women was assayed and compared to that of 30 surgically castrated patients.

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Adrenal Estrogens in Patients With Metastatic Breast Cancer

Cited by 2 publications

References 0 publications

Steroids Present in the Follicular Fluid of the Mare

Steroids Present in the Follicular Fluid of the Mare

Function of the Postmenopausal Ovary. Comparison of Urinary Estrogen and Gonadotropin Excretion and Response to Administration of FSH in Postmenopausal and Ovariectomized Women††

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