Adrenal ganglioneuromas: A 10-year experience in a Chinese population

Yang, Qing; Xu, Bin; Wang, Jian; Li, Gao; Wang, Linhui; Liu, Bing; Wang, Huiqing; Sun, Yinghao

doi:10.1016/j.surg.2009.11.010

Cited by 63 publications

(93 citation statements)

References 25 publications

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“…Histologically two benign subtype of GN-mature and maturing have been noted malignant transformation has also been reported [20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Primary Adrenal Tumors-Five Years Single Centre Experience

Patel¹,

Vanikar²,

Suthar³

et al. 2012

OJPathology

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Primary adrenal tumors are less commonly encountered in clinic. They may be functional/non-functional and noted incidentally when investigating for other problems. However there is no study available in Asian countries, and especially India regarding the incidence and natural history of these tumors. We carried out a study on adrenal tumors noted in our set-up for last five years to document the prevalence of adrenal tumors, their presentation along with the most common tumor followed by incidence of other tumors and their clinical and pathological presentation. This was a retrospective study in our hospital from June 2006 to 2011. 29 adrenalectomies performed over 5 years. Their clinical presentation and investigations were recorded and analyzed. Adrenal tumors accounted for 0.6% of total surgical specimens, 18 out of 29 belonged to males. Majority (85.2%) of the patients were adults with mean age, 39.8 years. Majority (79.3%) had presented with symptoms, incidentalomas were found in 20.7% patients out of which 2 belonged to potential kidney donors. Nonfunctioning tumors were noted in 58.6% patients. Pheochromocytoma was the commonest tumor noted in 68.9% followed by adrenal cortical adenoma in 13.7%, carcinoma in 6.9% and lipoma, myelolipoma and ganglioneuroma, 3.45% each. All the patients are doing well over a mean follow-up of 2.5 years. To our knowledge this is the first study on incidence and natural history of primary adrenal tumors which are less commonly encountered and usually have good prognosis.

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“…Histologically two benign subtype of GN-mature and maturing have been noted malignant transformation has also been reported [20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Primary Adrenal Tumors-Five Years Single Centre Experience

Patel¹,

Vanikar²,

Suthar³

et al. 2012

OJPathology

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“…However, DWI was able to contribute the diagnosis of lesion as benign with obtaining high ADC value. references they are characterized with S-100, NSE, and synaptophysin positivity (1,3). The histology of adrenal GN has been reported to be overlap with that of cortical adenoma/pheochromacytoma, and myelolipoma (1).…”

Section: Discussionmentioning

confidence: 99%

“…GN is composed of mature ganglion cells and Schwann cells in a fibrous stroma. Adrenal GN is usually asymptomatic and hormonally inactive, but some of them secrete catecholamines and their metabolites -cortisol or androgens (1)(2)(3).…”

mentioning

confidence: 99%

Dopamine-Secreting Giant Adrenal Ganglioneuroma: Clinical and Diffusion-Weighted Magnetic Resonance Imaging Findings

Polat¹,

Aslan²,

Atmaca³

et al. 2014

Journal of the Belgian Society of Radiology

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We report a case of a dopamine-secreting giant primary adrenal ganglioneuroma (gn) in a 29-year-old male patient. although the patient was clinically silent, the 24-hour urine levels of dopamine, normetanephrine, homovanillic acid and vanillyl mandelic acid were elevated. abdominal ultrasonography and magnetic resonance imaging showed a large solid tumor with calcifications and a slightly lobular edge on the left adrenal gland. a tumor, 13 × 23 × 25 cm in size, was completely resected without morbidity. a 2-year follow-up with computed tomography showed that the postoperative course of the patient was uneventful.

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“…Malignant transformation is rarely reported. It needs careful evaluation & surgical resection is the choice of therapy for such tumors [2,3,8].…”

Section: Discussionmentioning

confidence: 99%

“…GN rarely occurs in the adrenal gland, hence diagnosis is usually difficult [1]. GN do not secrete excess catecholamines or steroid hormones and are often clinically silent and asymptomatic even if they are large [2]. Detection of this tumor has increased with availability of imaging procedures like ultrasonography (USG)/computed tomography (CT)/magnetic resonance imaging (MRI) however histopathology still remains the gold standard for final diagnosis and ruling out a malignant tumor [3,4].…”

Section: Introductionmentioning

confidence: 99%

Non-functional adrenal gland ganglioneuroma: case report

Patel¹,

Vanikar²,

Trivedi³

2013

Res J Endocrinol Metab

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Background: Adrenal ganglioneuromas in young adults are rare and ill-understood. We report an incidentally detected adrenal gland tumor diagnosed as ganglioneuroma (mature type). Methods and result: Asian 33 years old male who presented with vomiting and epigastric pain for 2 months. USG and CTabdomen revealed well-defined rounded hypo-dense non-enhancing homogenous mass of left adrenal gland. Histopathology examination revealed a well-encapsulated benign tumor of mature ganglion cells and Schwann-like cells arranged in fascicles, staining strongly with NSE and s-100 proteins, with adjacent unremarkable adrenal cortex and medulla. Conclusion: Ganglioneuromas (GN) of adrenal gland in adults are very rare and can have serendipitious presentation. We describe such a non-functional adrenal GN in a young male.

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Adrenal ganglioneuromas: A 10-year experience in a Chinese population

Cited by 63 publications

References 25 publications

Primary Adrenal Tumors-Five Years Single Centre Experience

Primary Adrenal Tumors-Five Years Single Centre Experience

Dopamine-Secreting Giant Adrenal Ganglioneuroma: Clinical and Diffusion-Weighted Magnetic Resonance Imaging Findings

Non-functional adrenal gland ganglioneuroma: case report

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