Adrenal hormone response and psychophysiological correlates under psychosocial stress in individuals with irritable bowel syndrome

Sugaya, Nagisa; Izawa, Shuhei; Kimura, Kenta; Ogawa, Namiko; Yamada, Kosuke; Shirotsuki, Kentaro; Mikami, Ikuyo; Hirata, Kazuo; Nagano, Yuichiro; Nomura, Shinobu; Shimada, Hironori

doi:10.1016/j.ijpsycho.2012.01.006

Cited by 24 publications

(27 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two recent studies have used the TSST to examine the stress responsiveness of various parameters in IBS (Suarez-Hitz et al 2012;Sugaya et al 2012). Sugaya et al (2012) found that, in response to the TSST, the cortisol to dehydroepiandrosterone (DHEA) ratio was higher in IBS than in healthy controls, which is in line with our findings.…”

Section: Discussionsupporting

confidence: 90%

A sustained hypothalamic–pituitary–adrenal axis response to acute psychosocial stress in irritable bowel syndrome

et al. 2014

View full text Add to dashboard Cite

Background. Despite stress being considered a key factor in the pathophysiology of the functional gastrointestinal (GI) disorder irritable bowel syndrome (IBS), there is a paucity of information regarding the ability of IBS patients to respond to acute experimental stress. Insights into the stress response in IBS could open the way to novel therapeutic interventions. To this end, we assessed the response of a range of physiological and psychological parameters to the Trier Social Stress Test (TSST) in IBS.Method. Thirteen female patients with IBS and 15 healthy female age-matched control participants underwent a single exposure to the TSST. Salivary cortisol, salivary C-reactive protein (CRP), skin conductance level (SCL), GI symptoms, mood and self-reported stress were measured pre-and post-exposure to the TSST.Results. The hypothalamic-pituitary-adrenal (HPA) axis response to the TSST was sustained in IBS, as shown by a greater total cortisol output throughout (p = 0.035) and higher cortisol levels measured by an area under the curve with respect to ground (AUC G ) analysis (p = 0.044). In IBS patients, GI symptoms increased significantly during the recovery period following exposure to the TSST (p = 0.045). Salivary CRP and SCL activity showed significant changes in relation to stress but with no differential effect between experimental groups.Conclusions. Patients with IBS exhibit sustained HPA axis activity, and an increase in problematic GI symptoms in response to acute experimental psychosocial stress. These data pave the way for future interventional studies aimed at identifying novel therapeutic approaches to modulate the HPA axis and GI symptom response to acute psychosocial stress in IBS.

show abstract

Section: Discussionsupporting

confidence: 90%

A sustained hypothalamic–pituitary–adrenal axis response to acute psychosocial stress in irritable bowel syndrome

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Cortisol levels are impacted by psychological stress with higher levels of cortisol found in individuals experiencing chronic stress (Phillips et al 2010;Sugaya et al 2012), such as those with HAE who experience chronic pain combined with chronic trauma. High DHEAS levels provide protection and resilience from chronic stress (Lennartsson et al 2013;Phillips et al 2010;Sugaya et al 2012).…”

Section: Methodsmentioning

confidence: 99%

“…High DHEAS levels provide protection and resilience from chronic stress (Lennartsson et al 2013;Phillips et al 2010;Sugaya et al 2012). DHEAS levels are impacted by psychological distress, with lower levels of DHEAS found in individuals experiencing chronic stress (Phillips et al 2010;Sugaya et al 2012). It is important to note that HAE patients are likely to have lower levels of DHEA than the healthy population (Thon et al 2007).…”

Section: Methodsmentioning

confidence: 99%

Neurofeedback in Hereditary Angioedema: A Single Case Study of Symptom Reduction

Burns

2015

Appl Psychophysiol Biofeedback

View full text Add to dashboard Cite

Neurofeedback training was performed consisting of rewarding and encouraging 12-15 Hz brainwaves (SMR), while simultaneously discouraging 4-7 Hz brainwaves (theta) and 22-30 Hz brainwaves (high beta) in the right dorsal posterior quadrant of the brain (T4, P4) for 20 half-hour NFB sessions to determine the impact on cortisol levels, DHEA-S levels, scores on the Symptom Checklist-90-R (SCL-90-R), the quality of life inventory, and acute attack medication usage for a Hereditary Angioedema patient.

show abstract

“…In this way, there are also various results in the context of cortisol modifications in IBS (e.g. increased levels of cortisol in IBS [20][21][22], as cited in [16] vs. no modifications of cortisol levels in IBS patients [22][23][24][25][26], as cited in [16]), with the Patacchioli group demonstrating in 2001 [17] for example that IBS subjects showed significantly increased levels of salivary cortisol in their saliva in the morning, and exhibiting decreased levels of cortisol in the evening [17], while Sugaya et al [16], reported a significant increase of salivary cortisol levels in individuals with IBS only in the first week of the experimental prolonged stressful exposure, but not in the second week of the expose or a few days after [16].…”

Section: Abstract: Cortisol Serum Depression Irritable Bowel Syndromementioning

confidence: 99%

Serum Cortisol Levels Modifications in Patients with Depression and Irritable Bowel Syndrome

Hrițcu¹,

Pădurariu²,

Ciobîcă³

et al. 2019

Rev. Chim.

View full text Add to dashboard Cite

The correlations between depression and stress are quite accepted nowadays, as well as the fact that cortisol levels could also represent fundamental risk factors for major depressive disorder. However, when it comes to the modifications of cortisol levels in depression, the results are controversial. Same goes for the cortisol modifications in irritable bowel syndrome (IBS), which is a functional digestive disorder characterized by a strong biopsychological component, being highly influenced or exacerbated by stressful stimuli. Thus, in the present report we were interested in seeing if there are any serum cortisol levels variations in patients with depression and irritable bowel syndrome, by looking at cortisol modifications in two different groups of patients: a control group with major depression disorder and another study group composed by major depression disorder + IBS patients. Thus, our data presented here are suggesting that there is a significant increase in cortisol levels in the morning serum of the patients with major depression disorder + IBS, as compared to the group having only depression. The results presented here could have an important relevance in the context of managing the stress-related factors in the pathological entities described above.

show abstract

Adrenal hormone response and psychophysiological correlates under psychosocial stress in individuals with irritable bowel syndrome

Cited by 24 publications

References 30 publications

A sustained hypothalamic–pituitary–adrenal axis response to acute psychosocial stress in irritable bowel syndrome

A sustained hypothalamic–pituitary–adrenal axis response to acute psychosocial stress in irritable bowel syndrome

Neurofeedback in Hereditary Angioedema: A Single Case Study of Symptom Reduction

Serum Cortisol Levels Modifications in Patients with Depression and Irritable Bowel Syndrome

Contact Info

Product

Resources

About